Research Journal of Pharmacy and Technology

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Analysis of Copper (II) in Pharmaceutical Products using Micelle form with the Turbidity Method


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1 Chemistry Department, College of Science, University of Kerbala, Karbala, Iraq
     

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A modern and easy procedure performed using the turbidity method for the pre-concentration and estimating of Cu (II) in pharmaceutical samples. The limited solubility complex formed by the reaction of copper ions with cysteine and SDS as the surfactant. The copper content measured using the turbidity method. The effect of chemical and physical parameters including grouping of the ligand, SDS, pH, equilibration temperature and time and effect of salting are studied. The analytical qualities of the technique have been determined, which includes linear range (the range was between 0.158 -47.625μgmL-1), the coefficient of turbidity (k=13.21), limit of detection (LOD=0.1767 μg ml-1nd LOQ=0.5355 μg mL-1).All values are calculated using statistical programs, but the detection limit for Cu(II) ions based on eight times the standard deviation of the blanks (N:8) characterized as 3Sb/m (where Sb is the standard deviation of the blank and m is the slope of the calibration curve) is 0.0096μg mL-1 (3σ). The method employed successfully for the determination of Cu2+ in different local pharmaceutical formations.

Keywords

Copper in Pharmaceutical Products, Turbidity, Micelle.
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  • Analysis of Copper (II) in Pharmaceutical Products using Micelle form with the Turbidity Method

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Authors

Shaymaa Ibrahim Saeed
Chemistry Department, College of Science, University of Kerbala, Karbala, Iraq
Ahmed Fadhil Khudhair
Chemistry Department, College of Science, University of Kerbala, Karbala, Iraq
Sawsan Khudhair Abbas
Chemistry Department, College of Science, University of Kerbala, Karbala, Iraq
Hasan F. Alesary
Chemistry Department, College of Science, University of Kerbala, Karbala, Iraq

Abstract


A modern and easy procedure performed using the turbidity method for the pre-concentration and estimating of Cu (II) in pharmaceutical samples. The limited solubility complex formed by the reaction of copper ions with cysteine and SDS as the surfactant. The copper content measured using the turbidity method. The effect of chemical and physical parameters including grouping of the ligand, SDS, pH, equilibration temperature and time and effect of salting are studied. The analytical qualities of the technique have been determined, which includes linear range (the range was between 0.158 -47.625μgmL-1), the coefficient of turbidity (k=13.21), limit of detection (LOD=0.1767 μg ml-1nd LOQ=0.5355 μg mL-1).All values are calculated using statistical programs, but the detection limit for Cu(II) ions based on eight times the standard deviation of the blanks (N:8) characterized as 3Sb/m (where Sb is the standard deviation of the blank and m is the slope of the calibration curve) is 0.0096μg mL-1 (3σ). The method employed successfully for the determination of Cu2+ in different local pharmaceutical formations.

Keywords


Copper in Pharmaceutical Products, Turbidity, Micelle.

References