Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Validation of Telmisartan by UV Spectrophotometry Method


Affiliations
1 Department of Pharmaceutical Analysis, SRM College of Pharmacy, Kattankulathur, Tamil Nadu, India
     

   Subscribe/Renew Journal


A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The zero order spectra of Telmisartan in 0.1N NaOH shows λmax at 295.0 nm and estimation was carried out by A(1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2=0.999) over the concentration range of 4-24 μg/mL. The proposed method was validated for its accuracy, precision, specificity, ruggedness and robustness. The method can be adopted in its routine analysis.

Keywords

Telmisartan, 0.1N NaOH, UV-Spectrophotometric.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ajit Pandey, H. Sawarkar, Mukesh Singh, Dr. P Kashyap, Priyanka Ghosh. UV- Visible Spectrophotometric Method for estimation of Telmisartan in Bulk and Tablet Dosage Form. International Journal of Chem Tech Research.2011;3(2): 657-660.

  • Dharmendra K. Damor, Rajashree C. Mashru. Method development and validation of simultaneous estimaton of cilostazol and Telmisartan. International Bulletin of Drug Research. 2015:5(8): 12-22.

  • K. Sonia, Dr. M. Nappinnai, Dr. P. Panneerselvam. Stability indicating Method Development and Validation of Telmisartan and Ramipril by UV Spectrophotometry. Research J. Pharm. and Tech.2018: 11(7): 3087-3090.

  • K. P. Hirpara, Dave V. M., Dr. S. D. Faldu, Dr. B. D. Patel. UVSpectrophotometric Determination for Simultaneous Estimation of Amlodipine Besylate and Telmisartan in Combination. Journal of Pharmaceutical Science and Bioscientific Research.2012:2(3):133137.

  • Mayur Modi, Rikin Shah and R.C. Mashru. Development and Validation Of Spectrophotometric Methods For Simultaneous Estimation Of Metoprolol Succinate And Telmisartan In Combined Pharmaceutical Formulation. International Journal Of Pharmaceutical Science and Research. 2012:3(5): 1348-1354.

  • Riddhi Patel, Dilip G. Maheshwari. UV Spectrophtometric Methods For Simultaneous Estimation Of Telmisartan And Cilostazol In Synthetic Mixture. Pharma Science Monitor. 2015: 6(1):276-291.

  • Sonia K, Manikandan K, Hamunyare Ndwabe, Peddamadi Bhavya Sree, Lakshmi KS. Method Development and Validation of simultaneous estimation for Amlodipine besylate and Olmesartan medoxomil by HPTLC method. International Journal of Research in Pharmaceutical Sciences.2018: 9(1): 201-205.


Abstract Views: 203

PDF Views: 0




  • Validation of Telmisartan by UV Spectrophotometry Method

Abstract Views: 203  |  PDF Views: 0

Authors

Sheetal
Department of Pharmaceutical Analysis, SRM College of Pharmacy, Kattankulathur, Tamil Nadu, India
K. Sonia
Department of Pharmaceutical Analysis, SRM College of Pharmacy, Kattankulathur, Tamil Nadu, India
K. S. Lakshmi
Department of Pharmaceutical Analysis, SRM College of Pharmacy, Kattankulathur, Tamil Nadu, India

Abstract


A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The zero order spectra of Telmisartan in 0.1N NaOH shows λmax at 295.0 nm and estimation was carried out by A(1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2=0.999) over the concentration range of 4-24 μg/mL. The proposed method was validated for its accuracy, precision, specificity, ruggedness and robustness. The method can be adopted in its routine analysis.

Keywords


Telmisartan, 0.1N NaOH, UV-Spectrophotometric.

References