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A Review on Hydrotropic Solubilization for Poorly Water Soluble Drugs:Analytical Application and Formulation Development


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1 Affiliated to Savitribai Phule Pune University, Pune. Maharashtra, India
     

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Solubilisation of poorly soluble drugs is encountered as a challenge in screening studies of new chemical entities as well as its formulation development is obstacle. A number of methodologies can be adapted to improve solubility of poor water soluble drug and its bioavailability. Hydrotropes possess the ability to increase the solubility of sparingly soluble and poorly soluble drugs in water. It is a molecular phenomenon, adding a second solute (i.e. hydrotrope) helps to increase the aqueous solubility of poorly soluble drug. The presence of a excess quantity of one solute enhances the solubility of another solute. Various organic solvents are used for the development of analytical methods for poorly water soluble drugs. The major drawback of such solvents is cost, toxicity and environmental hazards. To overcome these issues less costly hydrotropic agents have gain wide application for the development of analytical methods for routine analysis of marketed dosage form and developed dosage forms. The mixed hydrotropy approach suggests the minimum amount of the hydrotropic agents as a blend of two or more agents. Such blends results in lesser quantity as that of single hydrotropic agents. Similarly the hydrotropic agents are now days widely used to develop dosage forms as solid dispersion, mouth dissolving tablets, injections to improve therapeutic effectiveness and bioavailability for poorly water soluble drugs.

Keywords

Solubility, Hydrotropy, Mixed Hydrotrophy, Dosage Form.
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  • Behera AL, Sahoo SK, Patil SV. Enhancement of solubility: a pharmaceutical overview. Der pharmacia letter. 2010; 2 (2): 310-318.

  • India Pharmacopoeia. Govt. of India Vol-I. Ghaziabad: Ministry of Health and Family Welfare, 4th edition. Published by The Indian Pharmacopoeia Commission. 2014, 174.

  • Jain P, G oal A, Sharma S, Parmar M., Solubility enhancement techniques with special emphasis on hydrotropy, International Journal of Pharma Professional’s Research. 2010; 1(1): 34-35.

  • Neuberg C. Hydrotropy. Biochemistry Z. 1916; 76: 107-109.

  • Martin A, Bustamante P, Chun Ahc. Physical Pharmacy, New Delhi, b.i. Wavely pvt. Ltd, 1994,4,223

  • Dhapte V, Mehta P. Advances in Hydrotropic Solutions: An Updated Review, Petersburg Polytechnical University Journal: Physics and Mathematics. 2015; 1: 424–435.

  • Masthannamma SK, Sravani K, Ananta sridhar T, Siva Sankar Naik B. UV Spectrophotometric Determination of Metronidazole in Bulk and Pharmaceutical Dosage Form Using Hydrotropic Solubilization Technique. Journal of global trends in pharmaceutical sciences. 2015; 6(1): 2365 – 2371.

  • Aher BO, Jain NP, Jain UN, Paithankar AR, Bagul TP, Gaikwad SS. Novel Spectrophotometric Estimation of Acyclovir Using Hydrotropic Solubilizing Agent. Innovational Journal of Chemistry. 2015; 1 (3): 22-32.

  • Masthannamma SK, Ananta Sridhar T, Siva Sankar Naik. B, Anil Kumar T, UV Spectrophotometric Determination of Tinidazole in Bulk and Pharmaceutical Dosage Form Using Hydrotropic Solubilization Technique. International journal of research and development in pharmacy and life sciences. 2015; 4 (3): 1582-1589.

  • Lurdhu Mary K., Manohar babuan S, Ecofriendly Spectroscopic Method for Estimation of Etraverine by Using Hydrotropic Agents. World journal of pharmacy and pharmaceutical sciences. 2015; 4(3): 655-662.

  • Rane J, Thakre V, Bakal RL, Patil S, Novel Spectrophotometric Estimation of Gliclazide by Using Mixed Hydrotropic Solubilization Phenomenon. Journal of drug discovery and therapeutics. 2015; 3 (27): 8-10.

  • Aher BO, Jain NP, Shinde GS, Gayke A, Jadhav VK, Bankar KA, Novel Spectrophotometric Estimation of Atenolol using Hydrotropic Solubilizing Agent. International journal of advanced research in biological sciences. 2015; 2 (4): 151–156.

  • Niraimathi V, Jerad suresh A, Alageswaran A, UV Spectrophotometric Determination of Fenofibric Acid by Using Hydrotropy. International journal of pharma sciences and research. 2015; 6 (2): 451-458.

  • Yadav NK, Shukla T, Upmanyu N, Pandey SP, Khan MA, Novel Application of Mixed Hydrotropic Solubilization Technique in The Formulation and Evaluation of solid dispersion of Flupirtine Maleate, Journal of Drug Delivery and Therapeutics. 2018; 8 (5) :481-488.

  • Pal TK, Panda M , Roy C. Development and Validation Of a Novel Analytical Method For Estimation Of Telmisartan In Tablet Dosage Forms Using Hydrotropic Solubilization. World Journal of Pharmaceutical Research. 2014; 3 (5): 577-598.

  • Kate BA, Phulzalke SB, Deshmukh MT, Solubility Enhancement of Poorly Water Soluble Drug Zaltoprofen by Mixed Hydrotropy Approach . Asian journal of Biomedical and Pharmaceutical Sciences. 2016; 6(57): 32-39.

  • Kaushik A, Jat RK. Solubility Enhancement of Miconazole by Formulation of Hydrotropic Solid Dispersions. Journal of Drug Delivery and Therapeutics. 2017; 7 (3): 117-126.

  • Agrawal S, Kasturi M. Hydrotropic Solubilization: A Promising Technique to Enhance Solubility of Poorly Water Soluble Drug Lumafantrine. International Journal of Pharmaceutical Sciences and Research. 2018; 9 (1): 175-181.

  • Khan MA. Enhancement of Solubility of Poorly Water Soluble Drugs Diclofenac Sodium by Mixed Solvency Approach, International Journal of Research and Development in Pharmacy and Life Sciences. 2015; 4 (6): 1835-1837.

  • Phulzalke SB, Kate BA, Bagade MY, Solubility Enhancement of Telmisartan Using Mixed Hydrotropy Approach. Asian Journal of Biomedical and Pharmaceutical Sciences. 2015; 5 (50): 37-39.

  • Maheshwari RK, Prasad S, Pandey P, Wanare G. Novel Spectrophotometric Analysis of Piroxicam Tablets Using Ibuprofen Sodium as Hydrotropic Solubilizing Agents. International Journal of Pharmaceutical Sciences and Drug Research 2010; 2(3): 210-212.

  • Maheshwari RK, Jawade S, Fouzdar A. Formulation Development of Aqueous Injection of Poorly Soluble Drug Using Mixed Hydrotropic Solubilization Concept and Its Evaluation, International Journal of Pharmaceutical Sciences and Drug Research 2015; 7 (1): 8-12.

  • Patil CD, Matore BW, Dhekale PS, Spectrophotometric Determination Of Glipizide by Using Hydrotropic Solubilizing Agent, International Journal of Current Advanced Research. 2017; 6 (9): 5728-5730.

  • Madan JR, . Pawar K, T, Dua K, Solubility enhancement studies on lurasidone hydrochloride using mixed hydrotropy. International Journal of Pharmaceutical Investigation. 2015; 5 (2): 114-120.

  • Madan JR, Kamate VJ, Dua K, Awasthi R. Improving the Solubility of Nevirapine Using a Hydrotropy and Mixed Hydrotropy Based Solid Dispersion Approach, Polymers In Medicine. 2017; 47 (2): 83–90.

  • Maheshwari RK, Gupta HM, Singh M, Ramchandani U, Pandeya SP, Novel Application of Hydrotropic Solubilization in The Spectrophotometric Analysis of Gatifloxacin in Solid Dosage Form. Asian Journal of Chemistry. 2008; 20 (1): 241-244.

  • Kamble R, Sharma S, Mehta P, Norfloxacin Mixed Solvency Based Solid Dispersions: An In-Vitro and In-Vivo Investigation, Journal of Taibah University for Science. 2017; 11: 512–522.

  • Maheshwari RK, Indurkhya A. Formulation and Evaluation of Aceclofenac Injection Made by Mixed Hydrotropic Solubilization Technique, Iranian Journal of Pharmaceutical Research. 2010; 9 (3): 233-242.

  • Avital B, David L, Jonathan MM, Riad A, Arik D, Hydrotropic Solubilization of Lipophilic Drugs For Oral Delivery: The Effects of Urea and Nicotinamide on Carbamazepine Solubility–Permeability Interplay, Frontiers in Pharmacology. 2016; 7: article 379.

  • Pawar P, Rawat SS, Mahajan YY, Galgatte UC, Maheshwari RK, Formulation Development and Evaluation of Aqueous Injection of Poorly Soluble Drug made by novel application of mixed solvency concept. International Journal of Drug Delivery. 2013; 5 :152-166.

  • Jaya S, Umadevi SK, Vardhan S, Lachoriya M, Rajeswari G, Kasturibai B, Solubility Enhancement of Candesartan Cilexetil by Using Different Hydrotropic Agents. European Journal of Pharmaceutical and Medical Research. 2015; 2(1): 339-353 .

  • Sharma A. Sharma S, Jha KK, Shekhar S. Formulation, Optimization and Evaluation of Mouth Dissolving Tablets of Piroxicam using Hydrotropic Solubilization Technique. International Research Journal of Pharmacy. 2017; 8 (12): 91-98.

  • Madan JR, Kamate VJ, Awasthi R, Dua K. Formulation, Characterization and In-Vitro Evaluation of Fast Dissolving Tablets Containing Gliclazide Hydrotropic Solid Dispersions. Recent Patents on Drug Delivery & Formulation. 2017; 11: 147-154.


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  • A Review on Hydrotropic Solubilization for Poorly Water Soluble Drugs:Analytical Application and Formulation Development

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Authors

Nilesh S. Kulkarni
Affiliated to Savitribai Phule Pune University, Pune. Maharashtra, India
Sanghamitra B. Ghule
Affiliated to Savitribai Phule Pune University, Pune. Maharashtra, India
Shashikant N. Dhole
Affiliated to Savitribai Phule Pune University, Pune. Maharashtra, India

Abstract


Solubilisation of poorly soluble drugs is encountered as a challenge in screening studies of new chemical entities as well as its formulation development is obstacle. A number of methodologies can be adapted to improve solubility of poor water soluble drug and its bioavailability. Hydrotropes possess the ability to increase the solubility of sparingly soluble and poorly soluble drugs in water. It is a molecular phenomenon, adding a second solute (i.e. hydrotrope) helps to increase the aqueous solubility of poorly soluble drug. The presence of a excess quantity of one solute enhances the solubility of another solute. Various organic solvents are used for the development of analytical methods for poorly water soluble drugs. The major drawback of such solvents is cost, toxicity and environmental hazards. To overcome these issues less costly hydrotropic agents have gain wide application for the development of analytical methods for routine analysis of marketed dosage form and developed dosage forms. The mixed hydrotropy approach suggests the minimum amount of the hydrotropic agents as a blend of two or more agents. Such blends results in lesser quantity as that of single hydrotropic agents. Similarly the hydrotropic agents are now days widely used to develop dosage forms as solid dispersion, mouth dissolving tablets, injections to improve therapeutic effectiveness and bioavailability for poorly water soluble drugs.

Keywords


Solubility, Hydrotropy, Mixed Hydrotrophy, Dosage Form.

References