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In vitro Antihyperglycemic Activity of Unripe Fruits Extracts of Artocarpus gomezianus


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1 Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
     

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Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.

Keywords

in vitro Antidiabetic, Artocarpus gomezianus, α-Glucosidase, α-Amylase Enzymes.
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  • Krishnamoorthy SR, Sarala P. Phytochemical studies of Artocarpus gomezianus wall. ex Trecul. var. lakoocha Roxb. fruits collected from various altitudes of central western ghats. Indian Journal of Natural Products and resources.2013, 4(4): 398-411

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  • In vitro Antihyperglycemic Activity of Unripe Fruits Extracts of Artocarpus gomezianus

Abstract Views: 487  |  PDF Views: 0

Authors

Jennifer Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
Ronald Fernandes
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
M. Vijay Kumar
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
K. Rajisha
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India
Ryna V. Lobo
Department of Pharmaceutical Chemistry, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte, Mangalore-575018, India

Abstract


Diabetes mellitus is a metabolic disorder which results from defects in insulin secretion. Among the various methods of diabetes management, herbal products are best alternative drug with zero side-effects. The aim of this work was to assess the phytochemicals qualitatively and to evaluate the anti-diabetic activity of unripe fruits extract of Artocarpus gomezianus. The in vitro alpha-amylase and alpha-glucosidase inhibitory studies were performed using different concentration of extract and compared with a standard drug. Our assay result suggests that methanolic extract of Artocarpus gomezianus exhibit dose-dependent increase in percentage inhibitory activity on α-glucosidase enzymes (IC50 is 70.29) and α-amylase (IC50 is 68.75). Acarbose was used as a standard drug.

Keywords


in vitro Antidiabetic, Artocarpus gomezianus, α-Glucosidase, α-Amylase Enzymes.

References