Research Journal of Pharmacy and Technology

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Application of Mathematical Models in Drug Release Kinetics of Lagerstroemia Speciosa Extract-phospholipid Complex


Affiliations
1 Associate Professor, Sal Institute of Pharmacy, Opp. Science City, Ahmedabad 380061, Gujarat,, India
2 NIMS Institute of Pharmacy, Jaipur, Rajasthan,, India
3 Anand Pharmacy College, Gujarat,, India
     

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The aim of present work is to govern and scrutinize the kinetics of drug release from the complex by employing various mathematical models. A study was done with Lagerstroemia speciosa extract-phospholipid complex, 50 mg/200mg by employing anticipation precipitation technique using soya lecithin and cholesterol as complex forming polymer. In-vitro drug release profile was carried out in phosphate buffer saline, pH 7.4 (900mL) using USP dissolution apparatus II (Paddle) at 50 RPM at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug release profile was best fitted with Korsmeyer-Peppas model and follows drug release kinetics which is diffusion controlled.

Keywords

Lagerstroemia speciosa extract-phospholipid complex; Diffusion; Coefficient of correlation; Kinetics of drug release.
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  • Application of Mathematical Models in Drug Release Kinetics of Lagerstroemia Speciosa Extract-phospholipid Complex

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Authors

Patel Anar J
Associate Professor, Sal Institute of Pharmacy, Opp. Science City, Ahmedabad 380061, Gujarat,, India
Singh R. P.
NIMS Institute of Pharmacy, Jaipur, Rajasthan,, India
Patel Vaibhav
Anand Pharmacy College, Gujarat,, India
Goswami Shambaditya
NIMS Institute of Pharmacy, Jaipur, Rajasthan,, India

Abstract


The aim of present work is to govern and scrutinize the kinetics of drug release from the complex by employing various mathematical models. A study was done with Lagerstroemia speciosa extract-phospholipid complex, 50 mg/200mg by employing anticipation precipitation technique using soya lecithin and cholesterol as complex forming polymer. In-vitro drug release profile was carried out in phosphate buffer saline, pH 7.4 (900mL) using USP dissolution apparatus II (Paddle) at 50 RPM at an extended time period of 0.5, 0.75, 1, 1.5, 2, 2.5, 3 and 4 hours. The drug release data was obtained, quantitatively correlated and interpreted with various mathematical models viz. Zero order model, first order model, Higuchi model and Korsmeyer-Peppas model and evaluated to understand the kinetics of drug release. The criterion for the most suitable model was based on the high degree of coefficient of correlation of drug release profile was best fitted with Korsmeyer-Peppas model and follows drug release kinetics which is diffusion controlled.

Keywords


Lagerstroemia speciosa extract-phospholipid complex; Diffusion; Coefficient of correlation; Kinetics of drug release.

References