Research Journal of Pharmacy and Technology

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Synthesis and Characterization of Mixed Ligand Complexes from Curcumin and New Schiff Base Derived from Isatin for Some Metallic Ions and Evaluation Biological Activities


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1 College of Remote Sensing and Geophysics, Al Karkh University of Science, Baghdad, Iraq
     

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This study describes the synthesis of new Schiff base ligand (L') derived from isatin with 2- amino-6-methylbenzothaizole, also prepared mixed ligand complexes from curcumin (HL) and Schiff base (L') with metal ions, give formula: [M(L)(L') Cl] where: M = [Mn, Co, Ni, Cu, Zn, Cd], With (M: HL: L') [1:1:1] in ethanol as a solvent. The Schiff base (L') and all complexes were characterized by spectroscopic measurements (IR, 1H,13C-NMR, UV-Vis, A.A., LC-mas), magnetic susceptibility, elemental microanalysis, molar conductivity, chloride content, and melting point. Based on the results obtained an octahedral geometrical formula was suggested for all prepared complexes. The evolution of biological activity for ligands and their complexes was valued for two kinds of bacteria: (Escherichia coli, Staphylococcus aureus) and only one type for each of the mildew Candida Albicans. The results showed that the biological activity of the complexes against the bacteria and mildew are best than the ligands.

Keywords

2-Amino-6-methylbenzothiazole, Isatin, Curcumin, Metallic Ions.
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  • Ali W, Saeed R. Synthesis, characterization and corrosion inhibition study of new heterocyclic compounds and schiff base with [Co (II), Ni (II), Cu (II) and Hg (II)] complexes. Sys Rev Pharm. 2020;11(10):134-143.

  • Prakash C, Raja S, Saravanan G, Kumar P, Selvam T. Synthesis and Evaluation of Antioxidant Activities of Some Novel Isatin Derivatives and Analogs. Asian J. Res. Pharm. Sci. 2011 Oct.-Dec;1(4): 140-143.

  • Awad S , Saeed R , Hussein F, Biochem. Cell. Arch. 2020 ;20 (2):6317-6321. 4. Ramachandran S, Raju K. Synthesis, Characterization and In-Vitro Anti-Microbial Screening of Novel Schiff Bases of Isatin Derivatives. Asian J. Research Chem. 2011 June; 4(6): 925-927.

  • Cerchiaro G, Aquilano K, Filomeni G, Rotilio G, Ciriolo M, Ferreira A. Journal of Inorganic Biochemistry. 2005; 99 : 1433-1440.

  • Filomeni G, Piccirillo S, Graziani I, Cardaci S, Ferreira A, Rotilio G, Ciriolo M. The isatin-Schiff base copper(II) complex Cu(isaepy)2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis. Carcinogenesis. 2009; 30(7):1115-1124

  • Alkam H, Atiyah E, Majeed N, Alwan W. Cupper (II) and Mercury (II) Complexes with Schiff Base ligands from Benzidine with Isatin and Benzoine: Synthesis, Spectral Characterization, Thermal Studies and Biological Activities. Systematic Reviews in Pharmacy. 2021; 12(1):107-115. DOI: 10.31838/srp.2021.1.19

  • Raj A, Vinnarasi J, Venkataraman R. Synthesis, Characterization and Biological Activity of Mixed Ligand Complexes of Isatin. Research J. Pharm. and Tech. October 2013; 6(10): 1121-1123.

  • Mohan M, Veena V, Reddy K. Synthesis, Characterization and Study of Cytotoxicity, Antioxidant properties of Isatin based mixed Ligand Complexes. Research J. Pharm. and Tech 2019; 12(8):3945-3950.

  • G Sweetha , B Sangeetha , S Prabhu. A Review on Curcumin Nanoparticles and Its Controlled Delivery to Treat Degenerative Diseases. Asian J. Pharm. Tech. 2013; 3(4): 218-222.

  • Bashiri M, Jarrahpour A., Nabavizadeh S, Karimian S, Rastegari B, Haddadi E, Turos E. Medicinal Chemistry Research. 2021; 30: 258–284.

  • Sharma R, Kumari N, Ashawat M, Verma C. Standardization and Phytochemical Screening analysis for Herbal Extracts: Zingiber officinalis, Rosc., Curcuma longa Linn., Cinnamonum zeylanicum Nees., Piper longum, Linn., Boerhaavia diffussa Linn. Asian J. Pharm. Tech. 2020; 10(3):127-133.

  • Gupta S, Kim J, Kannappan R, Reuter S, Dougherty P, et al., Role of nuclear factor kappaB-mediated inflammatory path¬ways in cancer-related symptoms and their regulation by nutritional agents. ExpBiol Med (Maywood). 2011; 236(6):658-671.

  • K. Sharma, R.V. Singh, N. Fahmi; Spectrochimica Acta Part A: Molec. and BiomolecSpectroscopy . 2010; 7(6):45.

  • Kumar K , Singh B. Synthesis, Characterization and anti-Microbial activity of Some 4-Thiazolidinone Conjugatives. Asian J. Pharm. Ana. 2020; 10(4):195-200.

  • Hassan Sh, Lateef S, Majeed I. Structural, Spectral and Thermal studies of new bidentate Schiff base ligand type (NO) derived from Mebendazol and 4-Aminoantipyrine and its metal complexes and evaluation of their biological activity. Research Journal of Pharmacy and Technology. 2020; 13(6) :3001-3006. DOI: 10.5958/0974-360X.2020.00531.4

  • Jainab N, Sivachidambaram P, Yuvaraju J, Beyatricks K, Raj B. Microwave Mediated Synthesis, Characterisation and Biological activity of Certain New Mannich Bases of Isatin and Coumarin. Asian J. Research Chem. February 2014; 7(2): 176-181.

  • George S.,Infrared and Raman Characteristic Group Frequencies , Formerly of Brunel, The University of West London, Middlesex.UK , 2010 .

  • Priya R., Department of Applied Chemistry Cochin University of Science and Technology, 2013.

  • Varsanyi G, "Vibrational Spectra of Benzene Derivatives", Academic Press, New York, 1969.

  • Sanmartim J., Bermejo M. R., Deibe A. M. G. and Rivas I. M.; J.Chem. Soc. Dalton Trans; 2000, 4174-4181.

  • Maher K, Mohammed S. Int J Cur Res Rev. 2015; 7(2):6-16.

  • Eissa H. J.BAOJ.Chem.. 2015; 1(1) :1-9.

  • Raman N, Raja J, Sakthivel A. J.chem.Sci.. 2007;119(4):303-310.

  • Rajasekar K and Ramachandramoorthy T. Int. J. Pharm. Bio. Sci. 2013 4(2):271- 276.

  • Hassan Sh, Lateef S. Synthesis, structural, thermal and biological studies for new Schiff base derived from Isoniazid and it's complexes with metal ions." Egyptian Journal of Chemistry. 2021; 64 (7): 3235-3243. DOI: 10.21608/EJCHEM.2021.42643.2861

  • S. A.Ahmed , A. O. Mohamed and A. A.Humada ; Journal of Kirkuk University –Scie.c Stud.; Vol. 4(2) ,(2009) , 37-45.

  • Joseph J , Janaki G. J. of Photochem. & Photobio. B: Biology. 2016(162) 86–92 .

  • AL-Noor T, Hameed R, El-ajaily M, Maihub A. Preparation and Spectroscopic Characterization of Chromium (III) and Iron (III) Mixed Ligand Complexes." Journal of Physics: Conference Series. IOP Publishing 2019; 1294 ( 5).

  • M. Shakir, S. Hanif, M.A. Sherwani, O. Mohammad, M. Azam and S. Al-Resayes . J. of Photochem. & Photobiol., B: Biology. 2016; (157) 39–56.

  • Hassan Sh, Lateef S, Majeed I. Structural, Spectral and Thermal Studies of New Bidentate Schiff Base Ligand Type (NN) Derived from Mebendazol and 2-Aminobenzothaizol and its Metal Complexes and Evaluation of their Biological Activity. Journal of Global Pharma Technology. 2018;10(7):307-317. https://orcid.org/0000-0001-5635-9889

  • Anupama B, Padmaja M , Kumari C. E-Journal of Chem. 2012; (1): 389-400 .

  • Vijayabaskaran M, Lakshmi G, Senthilraja M, Sivakumar P, Vaijayanthimala P, Perumal P. Synthesis, Characterization and Anti-Microbial Evaluation of Substituted Benzo[g]indol-2-one Derivatives. Research J. Science and Tech. 2011; 3(6): 313-317.

  • Hossain S, Zakaria , Zahan k . Structural and Biological Activity Studies on Metal Complexes Containing Thiosemicarbzone and Isatin Based Schiff Base: A Review. Asian J. Research Chem. 2017; 10(1):6-13.

  • Damayanti P. , Ritmaleni , Setyowati E . Synthesis and antibacterial activity of 4-Piperidone curcumin analogues against Gram-positive and Gram-negative bacteria. Research J. Pharm. and Tech. 2020; 13(10):4765-4769.

  • H Salloom, , Lateef S, Hassan Sh. Structural, Spectral and Thermal Studies of Novel Tridentate Schiff Base Ligand Type (NOO) as Donor Atoms Derived from Nalidixic Acid and 4-Aminoantipyrine and Metal Complexes and Evaluation of their Biological Activity. Journal of Global Pharma Technology. 2020;12(2):26-36. https://orcid.org/0000-0001-5635-9889.


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  • Synthesis and Characterization of Mixed Ligand Complexes from Curcumin and New Schiff Base Derived from Isatin for Some Metallic Ions and Evaluation Biological Activities

Abstract Views: 274  |  PDF Views: 0

Authors

Shaimaa Ahmad Hassan
College of Remote Sensing and Geophysics, Al Karkh University of Science, Baghdad, Iraq

Abstract


This study describes the synthesis of new Schiff base ligand (L') derived from isatin with 2- amino-6-methylbenzothaizole, also prepared mixed ligand complexes from curcumin (HL) and Schiff base (L') with metal ions, give formula: [M(L)(L') Cl] where: M = [Mn, Co, Ni, Cu, Zn, Cd], With (M: HL: L') [1:1:1] in ethanol as a solvent. The Schiff base (L') and all complexes were characterized by spectroscopic measurements (IR, 1H,13C-NMR, UV-Vis, A.A., LC-mas), magnetic susceptibility, elemental microanalysis, molar conductivity, chloride content, and melting point. Based on the results obtained an octahedral geometrical formula was suggested for all prepared complexes. The evolution of biological activity for ligands and their complexes was valued for two kinds of bacteria: (Escherichia coli, Staphylococcus aureus) and only one type for each of the mildew Candida Albicans. The results showed that the biological activity of the complexes against the bacteria and mildew are best than the ligands.

Keywords


2-Amino-6-methylbenzothiazole, Isatin, Curcumin, Metallic Ions.

References