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Flaxseed Mucilage Hydrogel Based Floating Drug Delivery System: Design and Evaluation


Affiliations
1 B.Pharm. Final Year Student, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur, University, Nagpur, (MS), India
2 Asst. Professor, Pharmacology Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
3 Asst. Professor, Regulatory Affair Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, India
4 Professor, Quality Assurance Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
5 Asst. Professor, Pharmaceutic Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, India
     

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Natural polymer-based plant polysaccharides and proteins have been most widely explored as an adjuvant in the dosage form formulation. Here we design a novel gastro-retentive floating tablet, based on a polysaccharide material from Flaxseed (Linum usitatissimum L.) for Domperidone. After oral administration; Domperidone showed good solubility in acidic pH but significantly reduced solubility in alkaline medium. So that to increase the absorption and bioavailability of Domperidone, it is necessary to increase the retention time in the upper part of the Gastrointestinal tract (GIT) by developing a floating sustained drug delivery system. The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose K 100 M (HPMC K100 M), Carbopol 934 and Flaxseed mucilage. Hardness, friability, weight variation, thickness, disintegration time of tablet formulations were within acceptable limits. The overall results explained that the optimized formulation F5 prepared by the exact ratio of Flaxseed mucilage, HPMC K100 M, Carbopol, could be more efficient on floating and sustained release of Domperidone in the upper part of GIT as compared to the tablets prepared by using HPMC K100 M and Carbopol 934 only. These findings indicated that Flaxseed can be used to develop novel gastro-retentive sustained release drug delivery system with the double advantage of sustained drug release at the upper part of GIT.

Keywords

Floating tablet, Flaxseed mucilage, Sustained release, Gastroretentive, Drug release kinetics.
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  • Flaxseed Mucilage Hydrogel Based Floating Drug Delivery System: Design and Evaluation

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Authors

Shreya Ramteke
B.Pharm. Final Year Student, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur, University, Nagpur, (MS), India
Naresh Haigune
B.Pharm. Final Year Student, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur, University, Nagpur, (MS), India
Sachin More
Asst. Professor, Pharmacology Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
Shilpa Pise
Asst. Professor, Regulatory Affair Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, India
Ajay Pise
Professor, Quality Assurance Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), India
Rohini Kharwade
Asst. Professor, Pharmaceutic Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, India

Abstract


Natural polymer-based plant polysaccharides and proteins have been most widely explored as an adjuvant in the dosage form formulation. Here we design a novel gastro-retentive floating tablet, based on a polysaccharide material from Flaxseed (Linum usitatissimum L.) for Domperidone. After oral administration; Domperidone showed good solubility in acidic pH but significantly reduced solubility in alkaline medium. So that to increase the absorption and bioavailability of Domperidone, it is necessary to increase the retention time in the upper part of the Gastrointestinal tract (GIT) by developing a floating sustained drug delivery system. The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose K 100 M (HPMC K100 M), Carbopol 934 and Flaxseed mucilage. Hardness, friability, weight variation, thickness, disintegration time of tablet formulations were within acceptable limits. The overall results explained that the optimized formulation F5 prepared by the exact ratio of Flaxseed mucilage, HPMC K100 M, Carbopol, could be more efficient on floating and sustained release of Domperidone in the upper part of GIT as compared to the tablets prepared by using HPMC K100 M and Carbopol 934 only. These findings indicated that Flaxseed can be used to develop novel gastro-retentive sustained release drug delivery system with the double advantage of sustained drug release at the upper part of GIT.

Keywords


Floating tablet, Flaxseed mucilage, Sustained release, Gastroretentive, Drug release kinetics.

References