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Evaluation of N – Butanol Fraction of Albizia Procera (Roxb.) Benth Against Diabetes Mellitus with Rats


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1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai 3., India
     

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The antidiabetic activity of n–butanol fraction of Albizia Procera was evaluated in Streptozotocin induced diabetic rats. The n–butanol fraction of Albizia Procera (200 and 400 mg/kg) were administered to Streptozotocin induced diabetic rats for 14 days and blood glucose levels (BGLs) of the diabetic rats were monitored at intervals of hours and days throughout the duration of the treatment. The n-butanol fraction of Albizia procera was found to be non-toxic up to the dose of 2000mg/kg and did not cause any death of the tested animals. STZ induced rats significantly increase the blood glucose level as compared to other groups. N- butanol fraction produces dose dependent effect as the high dose (400mg/kg) shows more significant antidiabetic action compared to 200mg/kg (P< 0.01).These results suggest that the N – Butanol fraction of Albizia Procera possess antidiabetic effect on Streptozotocin -induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.

Keywords

Antidiabetic, Albizia Procera, Streptozotocin, n – butanol, Blood glucose.
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  • Evaluation of N – Butanol Fraction of Albizia Procera (Roxb.) Benth Against Diabetes Mellitus with Rats

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Authors

D. Anand
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai 3., India
M. Sathish
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai 3., India

Abstract


The antidiabetic activity of n–butanol fraction of Albizia Procera was evaluated in Streptozotocin induced diabetic rats. The n–butanol fraction of Albizia Procera (200 and 400 mg/kg) were administered to Streptozotocin induced diabetic rats for 14 days and blood glucose levels (BGLs) of the diabetic rats were monitored at intervals of hours and days throughout the duration of the treatment. The n-butanol fraction of Albizia procera was found to be non-toxic up to the dose of 2000mg/kg and did not cause any death of the tested animals. STZ induced rats significantly increase the blood glucose level as compared to other groups. N- butanol fraction produces dose dependent effect as the high dose (400mg/kg) shows more significant antidiabetic action compared to 200mg/kg (P< 0.01).These results suggest that the N – Butanol fraction of Albizia Procera possess antidiabetic effect on Streptozotocin -induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.

Keywords


Antidiabetic, Albizia Procera, Streptozotocin, n – butanol, Blood glucose.

References