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Current Clinical Anticipation of Arbidol Against Covid-19: Possibilities


Affiliations
1 School of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University,, Ethiopia
2 GITAM School of Pharmacy, GITAM Deemed to be University, Hyderabad, Telangana State,, India
     

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World Health Organization (WHO) has assessed that coronavirus disease 2019 (COVID-19) as an epidemic. However, an effective antiviral for COVID-19 is still uncertain. Since the onset of the outbreak, the scientific and clinical community keep proposing many agents that would have efficacy against COVID-19. Arbidol is an indole core with proven effectiveness against influenza over the past few years apart from critics. The concrete hypothesis of arbidol interaction with spike glycoprotein prevents the entry of virus. Further, demonstrated clinical efficiency of arbidol against RNA virus and broad-spectrum inhibition of influenza A and B virus, adenovirus, and other viruses, including hepatitis C virus, drives us to seek more understating of the molecule and its clinical possibilities. In this review, we attempt to describe the many possible hypotheses of arbidol against Covid-19.

Keywords

SARS-COV-2, Arbidol, Umifenovir, Chemical, Mechanism.
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  • Current Clinical Anticipation of Arbidol Against Covid-19: Possibilities

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Authors

Ramana Hechhu
School of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University,, Ethiopia
Rangapuram Vasanthi
GITAM School of Pharmacy, GITAM Deemed to be University, Hyderabad, Telangana State,, India
Tamrat Balcha Balla
School of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University,, Ethiopia
Kaliaperumal J
School of Pharmacy, College of Health Sciences and Medicine, Wolaita Sodo University,, Ethiopia

Abstract


World Health Organization (WHO) has assessed that coronavirus disease 2019 (COVID-19) as an epidemic. However, an effective antiviral for COVID-19 is still uncertain. Since the onset of the outbreak, the scientific and clinical community keep proposing many agents that would have efficacy against COVID-19. Arbidol is an indole core with proven effectiveness against influenza over the past few years apart from critics. The concrete hypothesis of arbidol interaction with spike glycoprotein prevents the entry of virus. Further, demonstrated clinical efficiency of arbidol against RNA virus and broad-spectrum inhibition of influenza A and B virus, adenovirus, and other viruses, including hepatitis C virus, drives us to seek more understating of the molecule and its clinical possibilities. In this review, we attempt to describe the many possible hypotheses of arbidol against Covid-19.

Keywords


SARS-COV-2, Arbidol, Umifenovir, Chemical, Mechanism.

References