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A Desirability Approach for Antidiabetic and Antiinflammatory Efficacy of Ficus Subincisa Bark


Affiliations
1 Department of Chemistry, Kanya Gurukul Campus, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttrakhand,, India
     

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Background: This study aimed to examine the anti-inflammatory and antidiabetic effects of the green solvent extract from F.subincisa Buch-Ham.ExSm.This paper also explains how bio-based products have been highly safe and alternative to the use of organic solvent. Methods: The serial extraction was carried out with increasing polarity using a magnetic stirrer: d-limonene, Isopropyl alcohol, Ethyl lactate, and Hydroalcohol.The concentrated and dried extracts were subjected to analysis the antidiabetic activity and anti-inflammatory activity were assessed by employing standard in vitro techniques. Result: In vitro anti-inflammatory assays were performed using heat-induced bovine serum albumin (BSA) denaturation and erythrocyte membrane stabilization assays.α-amylase and α-glucosidase were used to evaluate the anti-diabetic activity of F.subincisa bark in vitro. Diclofenac sodium, Acarbose, and aspirin were used as reference drugs. The in vitro method showed significant anti-inflammatory and anti-diabetic properties of different bio-based extracts tested. Conclusions: Findings from this study showed that F.subincisa exhibited substantial anti-inflammatory and antidiabetic actions in vitro models.

Keywords

Ficus subincisa Buch.-Ham. Ex Sm.,d-limonene, Isopropyl alcohol, Ethyl lactate and Hydroalcohol, antidiabetic activity, anti-inflammatory activity.
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  • Chemat F, Vian MA, Ravi HK, Khadhraoui B, Hilali S, Perino S, et al. Review of Alternative Solvents for Green Extraction of Food and Natural Products : Panorama , Principles ,. 2019;

  • Dick FD. Solvent neurotoxicity. Occup Environ Med. 2006;63(3):221–6.

  • Ullah A. Diabetes mellitus and oxidative stress –– A concise review. Saudi Pharm J [Internet]. 2016;24(5):547–53. Available from: http://dx.doi.org/10.1016/j.jsps.2015.03.013

  • Godavari A, Amutha K. In vitro Antidiabetic Activity of Garcinia mangostana by Enzymatic Inhibition Assay. Res J Pharm Technol. 2017;10(2):508.

  • Amutha K, Aishwarya S. Evaluation of Antibacterial and Antidiabetic Activity and Phytochemical Analysis of Syzygium cumini (l.) Skeels. Seed. Res J Pharmacol Pharmacodyn [Internet]. 2010;2(5):348–50. Available from: http://www.indianjournals.com/ijor.aspx?target=ijor:rjppd&volume=2&issue=5&article=009

  • Arumugam G, Manjula P, Paari N. A review: Anti diabetic medicinal plants used for diabetes mellitus. J Acute Dis [Internet]. 2013;2(3):196–200. Available from: http://dx.doi.org/10.1016/S2221-6189(13)60126-2

  • Ghosh S, More P, Nitnavare R, Jagtap S, Chippalkatti R, Derle A, et al. Antidiabetic and Antioxidant Properties of Copper Nanoparticles Synthesized by Medicinal Plant Dioscorea bulbifera Nanomedicine & Nanotechnology. 2015;

  • WRESDIYATI T, SA’DIAH SITI, WINARTO ADI, FEBRIYANI V. Alpha-Glucosidase Inhibition and Hypoglycemic Activities of Sweitenia mahagoni Seed Extract. HAYATI J Biosci [Internet]. 2015;22(2):73–8. Available from: http://dx.doi.org/10.4308/hjb.22.2.73

  • Hoque M, Satish S. Antidiabetic Activity in Aqueous Leaf Extract of Ciceracida Linn in Alloxan induced Diabetes Rats Model . Res J Pharmacol Pharmacodyn. 2017;9(3):152.

  • Murthuza S, Manjunatha BK. “ In vitro and in vivo evaluation of anti-inflammatory potency of Mesua ferrea , Saraca asoca , Viscum album & Anthocephalus cadamba in murine macrophages raw 264 . 7 cell lines and Wistar albino rats ” The Oxford College of Engineering Bengaluru-560068 T. Beni-Suef Univ J Basic Appl Sci [Internet]. 2018; Available from: https://doi.org/10.1016/j.bjbas.2018.10.001

  • Kalkotwar RS, Saudagar RB. Design , Synthesis and anti microbial , anti-inflammatory , Antitubercular activities of some 2, 4, 5-trisubstituted imidazole derivatives . 2013;3(4):159–65.

  • Anyasor GN, Okanlawon AA, Ogunbiyi B. Evaluation of anti-inflammatory activity of Justicia secunda Vahl leaf extract using in vitro and in vivo inflammation models. 2019;

  • Lalitha P, Sachithanandam V, Swarnakumar NS, Sridhar R. Review on Anti-inflammatory Properties of Mangrove plants. Asian J Pharm Res. 2019;9(4):273.

  • Howlader MSI, Siraj MA, Dey SK, Hira A, Ahmed A, Hossain MH. Ficus hispida Bark Extract Prevents Nociception, Inflammation, and CNS Stimulation in Experimental Animal Model. Evidence-based Complement Altern Med. 2017;2017.

  • Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006;116(7):1793–801.

  • Arora R, Singh B, Vig AP, Arora S. Conventional and modified hydrodistillation method for the extraction of glucosinolate hydrolytic products: a comparative account. Springerplus. 2016;5(1):0–3.

  • Shettar AK, Sateesh MK, Kaliwal BB, Vedamurthy AB. In vitro antidiabetic activities and GC-MS phytochemical analysis of Ximenia americana extracts. South African J Bot [Internet]. 2017;111:202–11. Available from: http://dx.doi.org/10.1016/j.sajb.2017.03.014

  • Chandra S, Chatterjee P, Dey P, Bhattacharya S. Evaluation of in vitro anti-inflammatory activity of coffee against the denaturation of protein. Asian Pac J Trop Biomed [Internet]. 2012;2(1 SUPPL.):S178–80. Available from: http://dx.doi.org/10.1016/S2221-1691(12)60154-3

  • Nagaharika Y, kalyani V, Rasheed S, Ramadosskarthikeyan. Anti-inflammatory activity of leaves of Jatropha gossypifolia L. by hrbc membrane stabilization method. J Acute Dis [Internet]. 2013;2(2):156–8. Available from: http://dx.doi.org/10.1016/S2221-6189(13)60118-3

  • Capello C, Fischer U, Hungerbühler K. What is a green solvent? A comprehensive framework for the environmental assessment of solvents. Green Chem. 2007;9(9):927–34.

  • Villanueva Bermejo D, Angelov I, Vicente G, Stateva RP, Rodriguez García-Risco M, Reglero G, et al. Extraction of thymol from different varieties of thyme plants using green solvents. J Sci Food Agric. 2015;95(14):2901–7.

  • Welton T. Solvents and sustainable chemistry. Proc R Soc A Math Phys Eng Sci. 2015;471(2183).

  • Byrne FP, Jin S, Paggiola G, Petchey THM, Clark JH, Farmer TJ, et al. Tools and techniques for solvent selection: green solvent selection guides. Sustain Chem Process. 2016;4(1):1–24.

  • Tilburt JC, Kaptchuk TJ. Herbal medicine research and global health: An ethical analysis. Bull World Health Organ. 2008;86(8):594–9.

  • Shukla A, Kaur A, Shukla RK, Anchal. Comparative evaluation of antioxidant capacity, total flavonoid and phenolic content of Ehretia acuminata r. br. fruit. Res J Pharm Technol. 2019;12(4):1811–6.

  • Shukla RK. Phytochemical Screening , Proximate Analysis and Antioxidant Activity of Dracaena reflexa Lam . Leaves. 2015;77(September):640–4.

  • Meena AK, Singh U, Yadav AK, Singh B, Rao MM. Pharmacological and Phytochemical Evidences for the Extracts from Plants of the Genus Vitex – A Review. Int J Pharm Clin Res. 2010;2(1):1–9.

  • Shori AB ak. Screening of antidiabetic and antioxidant activities of medicinal plants. J Integr Med [Internet]. 2015;13(5):297–305. Available from: http://dx.doi.org/10.1016/S2095-4964(15)60193-5

  • Deepa P, Sowndhararajan K, Kim S, Park SJ. A role of Ficus species in the management of diabetes mellitus: A review. J Ethnopharmacol [Internet]. 2018;215:210–32. Available from: https://doi.org/10.1016/j.jep.2017.12.045

  • Sangeetha G, Vidhya R. In vitro anti-inflammatory activity of different parts of Pedalium murex ( L .). 2016;4(3):31–6.

  • Ramesh B, Umashankar RN, Babitha S. Synthesis and Anti-inflammatory Activity of Some New 2-Amino – 4, 6, Diaryl Pyrimidines.Asian J. Research Chem.2019;3(1):29-30.

  • Aejaz A, Khurshid IM, Gulam JK. Synthesis, characterization and anti-inflammatory activity some 1-(4-substituted)-2-(-4-(piperazine-1-yl) bis-thiazole-5-yl) 2-methyl-4-nitro-1h-imidazole-1-yl) ethanone. Asian J. Research Chem. 2017; 10(2):158-165.

  • Dipika V, Anna PN. Efficient One Pot Green Synthesis of 2-Aryl/ Heteryl- Benzothiazoles as Anti-inflammatory Agents. Asian J. Research Chem. 2010;3(4): 872-875.

  • Nupur Jaiswal, Arvind Kr. Singh. Synthesis of Some Novel 2,5-Disubstituted 1,3,4-Oxadiazole Derivatives as Potential Antibacterial and Anti-inflammatory activity. Asian J. Research Chem. 6(2): February 2013; Page 111-113


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  • A Desirability Approach for Antidiabetic and Antiinflammatory Efficacy of Ficus Subincisa Bark

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Authors

A . Shukla
Department of Chemistry, Kanya Gurukul Campus, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttrakhand,, India
P. Pokhriyal
Department of Chemistry, Kanya Gurukul Campus, Gurukul Kangri Vishwavidyalaya, Haridwar-249404, Uttrakhand,, India

Abstract


Background: This study aimed to examine the anti-inflammatory and antidiabetic effects of the green solvent extract from F.subincisa Buch-Ham.ExSm.This paper also explains how bio-based products have been highly safe and alternative to the use of organic solvent. Methods: The serial extraction was carried out with increasing polarity using a magnetic stirrer: d-limonene, Isopropyl alcohol, Ethyl lactate, and Hydroalcohol.The concentrated and dried extracts were subjected to analysis the antidiabetic activity and anti-inflammatory activity were assessed by employing standard in vitro techniques. Result: In vitro anti-inflammatory assays were performed using heat-induced bovine serum albumin (BSA) denaturation and erythrocyte membrane stabilization assays.α-amylase and α-glucosidase were used to evaluate the anti-diabetic activity of F.subincisa bark in vitro. Diclofenac sodium, Acarbose, and aspirin were used as reference drugs. The in vitro method showed significant anti-inflammatory and anti-diabetic properties of different bio-based extracts tested. Conclusions: Findings from this study showed that F.subincisa exhibited substantial anti-inflammatory and antidiabetic actions in vitro models.

Keywords


Ficus subincisa Buch.-Ham. Ex Sm.,d-limonene, Isopropyl alcohol, Ethyl lactate and Hydroalcohol, antidiabetic activity, anti-inflammatory activity.

References