Research Journal of Pharmacy and Technology

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Synthesis, and Antimicrobial Evaluation of New Hydrazone Derivatives of (2,4-dinitrophenyl) Hydrazine


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1 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad,, Iraq
     

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In this work, novel compounds of hydrazones derived from (2,4-dinitrophenyl) hydrazine were synthesized. Benzamides derivatives and sulfonamides derivatives were prepared from p-amino benzaldehyde. Then these compounds were condensed with (2,4-dinitrophenyl) hydrazine through Imine bond formation to give hydrazones compounds. The compounds were characterized using FT-IR (IR Affinity-1) spectrometer, and 1HNMR analyses. The majority of the compounds have a moderate antimicrobial activity against “Gram-positive bacteria staphylococcus Aureus, and staphylococcus epidermidis, Gram-negative bacteria Escherichia coli, and Klebsiella pneumoniae, and fungi species Candida albicans” using concentrations of 250 μg\ml.

Keywords

(2,4-dinitrophenyl) hydrazine, Schiff base, Hydrazone, Amide, Sulfonamides, Antibacterial and Antifungal activity.
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  • Synthesis, and Antimicrobial Evaluation of New Hydrazone Derivatives of (2,4-dinitrophenyl) Hydrazine

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Authors

Halah A. Sahib
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad,, Iraq
Mohammed K. Hadi
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad,, Iraq
Maadh Qusay Abdulkadir
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad,, Iraq

Abstract


In this work, novel compounds of hydrazones derived from (2,4-dinitrophenyl) hydrazine were synthesized. Benzamides derivatives and sulfonamides derivatives were prepared from p-amino benzaldehyde. Then these compounds were condensed with (2,4-dinitrophenyl) hydrazine through Imine bond formation to give hydrazones compounds. The compounds were characterized using FT-IR (IR Affinity-1) spectrometer, and 1HNMR analyses. The majority of the compounds have a moderate antimicrobial activity against “Gram-positive bacteria staphylococcus Aureus, and staphylococcus epidermidis, Gram-negative bacteria Escherichia coli, and Klebsiella pneumoniae, and fungi species Candida albicans” using concentrations of 250 μg\ml.

Keywords


(2,4-dinitrophenyl) hydrazine, Schiff base, Hydrazone, Amide, Sulfonamides, Antibacterial and Antifungal activity.

References