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Biological Screening and Structure Activity Relationship of Benzothiazole


Affiliations
1 Dr. Subhash Technical Campus, Faculty of Pharmacy, Khamdhrol Road, Junagadh, Gujarat,, India
2 Nobel Pharmacy College, Bhesan Road, Junagadh, Gujarat,, India
     

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Benzothiazole is a heterocyclic compound having nitrogen and sulphur. It's a bicyclic compound with a thiazole with benzene ring fused together. As per a review of the literature, benzothiazole is a primary moiety for the development of anticancer, antidiabetic, antioxidant, analgesic, and anti-inflammatory, antibacterial, antifungal, antiviral, anticonvulsant, antidepressant, antioxidant, and hepatoprotective agents. As a result, a list of biologically active benzothiazole derivatives has indeed been compiled in this study. The structure-activity relationship is analyzed based on the biological activities of benzothiazole derivatives and their substitution pattern. We also examined the mechanism of action of various benzothiazole derivatives, which can benefit researchers in the creation of new benzothiazole derivatives.

Keywords

Anticancer, Antidiabetic, Antioxidant, Benzothiazole, Hepatoprotective, SAR.
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  • Biological Screening and Structure Activity Relationship of Benzothiazole

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Authors

Khyati Bhagdev
Dr. Subhash Technical Campus, Faculty of Pharmacy, Khamdhrol Road, Junagadh, Gujarat,, India
Sibaji Sarkar
Nobel Pharmacy College, Bhesan Road, Junagadh, Gujarat,, India

Abstract


Benzothiazole is a heterocyclic compound having nitrogen and sulphur. It's a bicyclic compound with a thiazole with benzene ring fused together. As per a review of the literature, benzothiazole is a primary moiety for the development of anticancer, antidiabetic, antioxidant, analgesic, and anti-inflammatory, antibacterial, antifungal, antiviral, anticonvulsant, antidepressant, antioxidant, and hepatoprotective agents. As a result, a list of biologically active benzothiazole derivatives has indeed been compiled in this study. The structure-activity relationship is analyzed based on the biological activities of benzothiazole derivatives and their substitution pattern. We also examined the mechanism of action of various benzothiazole derivatives, which can benefit researchers in the creation of new benzothiazole derivatives.

Keywords


Anticancer, Antidiabetic, Antioxidant, Benzothiazole, Hepatoprotective, SAR.

References