Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Indira, A
- A Stability Indicating Method Development of Lopinavir and Rotinavir in Combined Tablet Dosage Forms by RP-HPLC
Abstract Views :149 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, AG & SG Degree College, Vuyyuru, Krishna District, Andhra Pradesh,, IN
2 Department of Chemistry, SV University, Tirupati, Andhra Pradesh,, IN
1 Department of Chemistry, AG & SG Degree College, Vuyyuru, Krishna District, Andhra Pradesh,, IN
2 Department of Chemistry, SV University, Tirupati, Andhra Pradesh,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 661-664Abstract
A new stability indicating RP-HPLC method was developed for simultaneous estimation of Lopinavir and Rotinavir in combined tablet formulations. Chromatography was carried out on a Kromasil C18 HPLC Column (250 x 4.6mm; 5μm) eluting with a mobile phase consisting of a 30:70v/v mixture of Phosphate buffer and acetonitrile at a flow rate of 1.0mL/minute. The wavelength detection was fixed at 220nm. Using standard addition method accuracy was assessed. The developed HPLC method was validated with respect to precision, specificity, accuracy, linearity and robustness. Forced degradation studies on the formulation were conducted by adopting the proposed method to assess the stability of the analytes under acid, base, peroxide, thermal and photolytic conditions and suitability of the method to resolve the degradation products.Keywords
Lopinavir Ritonavir, HPLC, Stability.References
- www.drugbank.ca/drugs/DB01601.
- Budavari S, Neil MJO, Smith A, Heckelman P, Kinneary J. The Merck Index. 12th ed. USA: Merck; 1996p.1418. Monograph No. 8402.
- T. Sudha, P. Shanmugasundram. Development and Validation of RP-HPLC and HPTLC Chromatographic Methods of Analysis for the Quantitative Estimation of Raltegravir Potassium in Pharmaceutical Dosage Form. Research J. Pharm. and Tech. 2011; 4(11) 1746-1750.
- Cvetkovic RS, Goa KL. Lopinavir/ritonavir: a review of its use in the management of HIV infection. Drugs 2003; 63: 769-802.
- Kaplan SS, Hicks CB. Lopinavir/ritonavir in the treatment of human immunodeficiency virus infection. Expert Opin Pharmacother 2005; 6: 1573-1585.
- N Appala Raju, Shabana Begum. Simultaneous RP-HPLC Method for the Estimation of the Emtricitabine, Tenofovir Disoproxil Fumerate and Efavirenz in Tablet Dosage Forms. Research J. Pharm. and Tech. 2008; 1(4) 522-525.
- Palani Shanmugasundaram, Kamarapu S. K. RP-HPLC Method for the Simultaneous Estimation and Validation of Amlodipine Besylate and Atenolol in Bulk and Tablet Dosage Form in Biorelevant Dissolution Medium. Research J. Pharm. and Tech 2017; 10(10): 3379-3385.
- Venkateswara Rao. B, Vidyadhara. S, Ram Babu. R, Praveen Kumar. B, Kishor kumar. G. Analytical Method Development and Validation for Simultaneous Estimation of Lopinavir and Ritonavir by RP-HPLC, Int. J. Res. Dev. Pharm. L. Sci. June -July, 2014, 3(4): 1074-1079.
- Vatchavai Bhaskara Raju, Bonthu Mohan Gandhi, Kamatham Srinivas Sumanth, Kolli Srinivas, Tupakula N Venkata Lakshmi Neeraja. RP-HPLC Method Development and Validation for Simultaneous Estimation of Telmisartan and Ramipril in pure and Pharmaceutical Dosage forms. Asian J. Research Chem. 2017; 10(2):179-185.
- T. Naga Ravi Kiran, P. Parvathi, J.N. Suresh Kumar. Development and Validation of RP-HPLC Method for the Simultaneous Estimation of Linagliptin, Empagliflozin and Metformin in Solid Dosage Forms. Asian J. Pharm. Ana. 2020; 10(3):117-124.
- Kirthi A, Shanmugam R, Mohana Lakshmi S , Ashok Kumar CK, Padmini K, Shanti Prathyusha M, Shilpa V. Analytical Method Development and Validation of a Stability-indicating RP-HPLC Method for the Analysis of Danazol in Pharmaceutical Dosage Form. Asian J. Pharm. Ana. 2016; 6(4): 227-234.
- L. Satyanarayana, S.V. Naidu, M. Narasimha Rao, Alok Kumar, K. Suresh. The Estimation of Darunavir in Tablet dosage form by RP-HPLC. Asian J. Res. Pharm. Sci. 2011; 1(3): 74-76.
- T. Gopi Raju, M. Gayatri Ramya, A. Rajesh, S. Kathirvel, Sanjay Kumar Gupta. ICH Guideline Practice- a Validated Stability- Indicating HPLC Method for the Determination of Efavirenz in Dosage Form. Res. J. Pharm. Dosage Form. & Tech. 2014; 6(1) 07-14.