Research Journal of Pharmacy and Technology

Saraswat Nikita ¹, Pal S. Rashmi ¹, Pal Yogendra ¹, Wal Pranay ¹, Wal Ankita ¹, A. K. Rai ¹

Affiliations
1 Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur, IN

Abstract

Background: Baldness is very common in males and females but predominantly it is seen more in males. This accounts for approximately 89-99 percent of hair loss. Though there are multiple causes responsible for causing baldness like hormones, hereditary, age factors, pollution, work environment, stress and many more. Objective: The objective of the paper is to evaluate the effectiveness of poly herbal hair oil prepared in the laboratory from sources such as hibiscus, leech, beehive, and onion which could be a potential hair growth promoter. Methods: The hair from the dorsal area of male wistar rats was shaved and they were divided into three groups having 6 rats each. Group I received the application of coconut oil daily, Group II received application of Minodixil (2%) ethanol extract as standard hair growth promoter and Group III received the application of poly-herbal oil prepared in the laboratory. The oil in respective groups was applied daily on rats of each group on the shaved surface. Results: The initiation of hair growth in all groups was calculated as a mean value to compare the results in different groups. Then the length of hair was noted on 15, 21, 30 and 40th day in centimeters. The mean length was calculated on each day for every group and the results were compared. The anagen/telogen ratio was also calculated for all the groups for better evaluation of results. Conclusion: The hair growth was maximum in the case of Group III, on which the poly herbal formulation of oil was applied daily. The hair growth in Group II (Minoxidil) was observed with optimum hair growth while the Group I was observed with least hair growth after the final evaluation and comparison of all the results. A significant hair growth effect from the poly herbal formulation oil was noted from the research conducted.

Keywords

Alopecia, Leech Oil, Hair Loss, Baldness, Poly Herbal Hair Oil, Herbal Extract.

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Rashmi Saxena Pal ¹, Nikita Saraswat ¹, Yogendra Pal ¹, Pranay Wal ¹, Ankita Wal ¹, A. K. Rai ¹

Affiliations
1 NH-2, Bhauti, Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur (U.P) 209305, IN

Abstract

Background: According to WHO (World Health Organization), more than 50 million pre-school children and approximately 2 billion adults are overweighed and more than half a billion are obese. Obesity is a matter of concern for population worldwide. For the treatment of obesity, the use of Ayurveda, as well as traditional forms of medication, has turned widely popular amongst the Indians. In fact, the world population is adopting many traditional medications, herbs, and formulations as a part of the lifestyle to cure obesity. Natural sources have always proved to bring long-term results as well as considered to be efficacious and safe as compared to the trending weight-loss product market. Objective: The objective of the paper is to evaluate and proclaim the effectiveness of extract of powdered poly herbs prepared in the laboratory from sources such as Ajowan fruit, Cinnamon bark, Leaves of pomegranate, Garlic buds and dried fruits of black pepper which could be potential anti-obesity source. Methods: The experiment was performed on Wistar male rats four weeks old weighing approx. 200-250g. They were administered the prepared herbal extract for evaluating the anti-obesity action. Throughout the experiment, the rats were divided into six groups with 6 rats in each group. Group I was considered as Normal Control Group hence normal pellet diet was given and no drug was administered to the rats of this group. Obesity was induced through HFD (high-fat diet) in standard and treated groups (Group II to VI). Group II was not given any medication to reduce obesity whereas a standard dose of Orlistat 5 mg/kg b. wt and was administered in Group III. Groups IV, V, VI were administered with Alcoholic Extracts containing different concentrations of Poly Herbal Powder and the anti-obesity action was recorded. The food intake, body weight, serum lipid profiles like, total TG, total serum cholesterol (TC), High-density lipoprotein (HDL), Low-density lipoprotein (LDL), Very Low-density lipoprotein VLDL, Blood glucose. Results: The average results of all groups were noted, plotted and analyzed where the results pointed out the anti-obesity activity in all groups. The standard group reported anti-obesity action whereas the treated groups with the maximum concentration was reported to be comparatively goodin anti-obesity action as compared to the standard group. Conclusions: The results concluded that the formulated herbal extract from powdered sources of dried herbs proved to be effective in the treatment of obesity. Multiple parameters were evaluated which directly pointed out that the extract is effective in relieving from the problem of obesity. The most effective treatment of the three concentrations of the prepared herbal extract was found to be Group VI HFD + Prepared Extract 200 mg/kg b. wt.

Keywords

Obesity, Polyherbal Extract, High-Fat Diet (HFD), High-Density Lipoprotein (HDL), Low-Density Lipoprotein (LDL), Herbal Extract, Serum Total Cholesterol (TC).

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