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Research Journal of Pharmacy and Technology

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2019
2022

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Prahasanti, Chiquita

The Efficacy of Human Dental Pulp Stem Cells in regenerating Submandibular Gland Defects in Diabetic Wistar Rats (Rattus novergicus)

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Authors

Septiana P. Suciadi ¹, Alexander P. Nugraha ², Diah S. Ernawati ³, Nurina F. Ayuningtyas ³, Ida B. Narmada ², Chiquita Prahasanti ⁴, Aristika Dinaryanti ⁵, Igo Syaiful Ihsan ⁵, Eryk Hendrinto ⁵, Helen Susilowati ⁵, Fedik Abdul Rantam ⁶

Affiliations
1 Universitas Airlangga, Surabaya, ID
2 Orthodontics Department, Universitas Airlangga, Surabaya, ID
3 Oral Medicine Department, Universitas Airlangga, Surabaya, ID
4 Periodontics Department, Universitas Airlangga, Surabaya, ID
5 Stem Cell Research and Development Center, Universitas Airlangga, Surabaya, ID
6 Virology and Immunology Laboratory, Microbiology Department, Universitas Airlangga, Surabaya, ID

Source

Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1573-1579

Abstract

Chronic hyperglicemia in Diabetes Mellitus caused microangiopathy in salivary gland. Human Dental Pulp Stem Cells (HDPSCs) suspected can regenerate the defect. The aim of this study was to analyze the efficacy of HDPSCs in stimulating angiogenesis, acinar cell numbers and Transforming Growth Factor-β (TGF-β) serum to regenerate submandibular gland defects in diabetic Wistar rats. Twenty-four male Wistar (250-350 g) rats 3-months-old were used. Rats were divided into 4 groups (n=6 each: a positive control group on Day 7 (DM) (C+7), a positive control group on Day 14 (DM) (C+14), a treatment group on Day 7 (DM+5.10⁵ HDPSCs transplantation intraglandular) (T7) and a treatment group on Day 14 (DM+5.10⁵ HDPSCs transplantation intraglandular) (T14). Wistar Rats were administered with 30 mg of Streptozotocin per kg of bodyweight to induce Diabetes Mellitus (DM). Histopathological examination with HE staining was performed to analyse neovascularization and acinar cell numbers. ELISA was performed to measure TGF-β serum. Statistical analysis used: A Tukey HSD or Bonferroni test after ANOVA or Kruskal Wallis test was performed (p<0.05) based on a Saphiro Wilk and Levene’s test (p>0.05). The highest acinar cell number was found in the T7 group [513.167±136.17] with no significant difference [p=0.136, p<0.05]. The highest capillaries were found in T14 [10.667±4.54] and TGF-β serum level [168.87±37.38] with significant difference [p=0.006; p<0.05] and [p=0.008, p<0.05]. HDPSCs can regenerate submandibular gland defects in Diabetic Wistar rats by stimulating angiogenesis, acinar cells number and TGF – β serum.

Keywords

Human Dental Pulp Stem Cells, Submandibular Gland Defect, Diabetes Mellitus, Acinar Cells, Angiogenesis, Transforming Growth Factor-β.

Full Text

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The Roles of Insulin Growth Factors-1 (Igf-1) in Bone Graft to Increase Osteogenesis

Abstract Views :149 | PDF Views:0

Authors

Chiquita Prahasanti ¹, Sonny Perdana ²

Affiliations
1 Department of Periodontology, Faculty of Dental Medicine - Airlangga University, Surabaya,, ID
2 Student of Periodontic Residency Program, Faculty of Dental Medicine - Airlangga University, Surabaya, ID

Source

Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1737-1742

Abstract

Background: Bone graft material is used with periodontal flap procedure that is expected to help the growth of new bone through the process of osteogenesis, osteoinduction, and osteoconduction. Some work must be done to support the regeneration of periodontal tissue, including the three key elements of principal, such as scaffolds (collagen and bone material), signal molecules (growth factors) and cells. IGF-1 is a growth factor that has been studied to stimulate the replication of osteoblasts and bone matrix synthesis of bone remodeling process. Osteocalcin is a specific product of osteoblasts, in a previous study that the increase of osteocalcin indicates an increase in bone formation markers. Osteopontin expression by kondrosit showed the role of these cell in sintesizing matrix that have a main role for osteoclast resorpsion dan bone remodeling. Objective: To know the effect of IGF-1 on bone healing process that has been applied xenograft with attention to osteoblast, osteoclast, osteopontin and osteocalcin expression in animal model. Methods: This study was an experimental study in the rabbit. Comparing two groups, xenograft + IGF-1 and others just xenograft, was applied to the tibia’s defect for 21 days. Results: There are significant differences between the groups. The expression of osteoblast, osteopontin and osteocalcin looks more numerous after 21 days on the xenograft + IGF-1 group than the group that only uses xenograft alone. Whereas expression of osteoclast was seen to be less in the xenograft + IGF-1 group. Conclusion: the use of IGF-1 as a fisiologic mediator in regenerate periodontal tissues proved to be effective with the increased expression of osteoblast, osteopontin, osteocalcin and decreased osteoclasts.

Keywords

Bone graft, IGF-1, Bone remodelling, Osteoblast, Osteoclast, Osteopontin, Osteocalcin.

Full Text

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Utilization of Polymethyl Methacrylate and Hydroxyapatite Composite as Biomaterial Candidate for Porous Trabecular Dental Implant Fixture Development: A Narrative Review

Abstract Views :150 | PDF Views:0

Authors

Chiquita Prahasanti ¹, Darmawan Setijanto ¹, Diah Savitri Ernawati ¹, Rini Devijanti Ridwan ¹, David Buntoro, Kamadjaja ², Anita Yuliati ¹, Asti Meizarini ¹, Nike Hendrijantini ², Agung Krismariono ², Shafira Kurnia Supandi ², Tania Saskianti ², Ratri Maya Sitalaksmi ², Djoko Kuswanto ³, Tansza Setiana Putri ², Nastiti Faradilla Ramadhani ², Muhammad Dimas Adiya Ari ², Alexander Patera Nugraha ²

Affiliations
1 Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya,, ID
2 Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, ID
3 Design Product Engineering Department, Institute Technology Sepuluh November, Surabaya,, ID

Source

Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1863-1869

Abstract

Polymethyl Methacrylate (PMMA) and Hydroxyapatite (HA) utilization as single materials are rarely used as dental implant materials. There is a promising hope by combining these two materials as a dental implant fixture. Nevertheless, there is a limited information of PMMA/HA composite utilization as dental implant material. The aims of this narrative review is to describe the potential of PMMA/HA composite utilization as biomaterial candidate for porous trabecular dental implant fixture development. This narrative review finds the potential of PMMA/HA composite as biomaterial candidate for porous trabecular dental implant. The keywords "Biomaterial," "Dental Implant," "Hydroxyapatite," "Osseointegration," and "Polymethyl Methacrylate" were used in a web-based search of PubMed, NCBI, Scopus, ScienceDirect, and ResearchGate databases. PMMA is non-toxic, cost-effective, biocompatible, simple to manipulate, and has strong mechanical properties in the oral cavity. Furthermore, osteoblastic cell adhesion, development, and differentiation are aided by the use of HA as a biomaterial to induce bone formation. Nonetheless, due to its rapid absorption and degradation, single HA is seldom used as a dental implant material. Developing dental implant composite has been extensively studied, among them are the fabrication of PMMA/HA. PMMA/HA has fairly good physical characteristics with a compressive strength, good bioaffinity properties, biocompatible with bone cells. The osteoconductivity of HA enhance the bioactivity of the composite materials, thus making the dental implant to have an excellent osseointegration. We propose that there is a possibility of utilization of PMMA/HA composite as biomaterial candidate for porous trabecular dental implant fixture.

Keywords

Biomaterial, Dental Implant, Hydroxyapatite, Osseointegration, Polymethyl Methacrylate.

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