Research Journal of Pharmacy and Technology

S. R. Suseem ¹, Dhanish Joseph ¹

Affiliations
1 School of Advanced Sciences, VIT, Vellore, IN

Abstract

Naringin and naringenin are the two common flavonoids present in the citrus fruits especially in grapefruit. Both this does wonderful functions in human body. It is being contraindicated with many of the drug products due to extensive variation in the kinetics of drugs when both dug and this flavonoid administered together. Thus all the doctors counsel the patients not to have grape fruit with many of the drugs. The common people or the patients are much worried in taking the citrus fruit even after completion of the treatment because of certain myth behind this. The current study aims to reveal the reality behind this caption. The review conducted confirms various proven therapeutic activities of naringin and naringenin as a supplement and certain synergistic effects. It is proven that the consumption of either grape fruit or as naringin or naringenin itself keeps the body healthy away from various illnesses. And it is highly active against various major life style disorders and even as an anti-neoplastic agent.

Keywords

Naringin, Hyperlipidemia, Antineoplastic, DNA Repair, Anti-inflammatory, Bone Marrow Protective.

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Dhanish Joseph ¹, Maria Jose ¹

Affiliations
1 Nirmala College of Pharmacy, Department of Pharmaceutics, Muvattupuzha, Kerala, IN

Abstract

Magnetically modulated system is a promising targeted drug delivery approach which uses an external magnetic field to control the delivery of drug at a specific site avoiding other cellular toxicities. These magnetic particles have the ability to accumulate at a desired site by the guidance of an external magnetic field. So, magnetically modulated materials can be used for diagnostic and targeted drug delivery approaches. This review describes about various applications of magnetically modulated system. Magnetic nanoparticles can be used in a wide variety of applications ranging from contrast agents for magnetic resonance imaging to the destruction of cancer cells via hyperthermia treatment and targeted therapy. Superparamagnetic nanoparticles are promising candidates for gene delivery. The immobilization of enzymes on magnetic nanoparticles helps to increase the enzyme activity and stability which enhances their applicability in bioreactors and biosensors. Magnetically responsive microspheres can be used in bio-separation techniques to remove cells and molecules. Magnetic bead-based immunoassay can be applied to bio-molecule detection and analysis systems. Magnetic polymeric microspheres have the capacity to bind biological molecules which helps to separate RBC from the whole blood. Magnetic arterial embolization hyperthermia can target liver cancers through duel effects of local hyperthermia and arterial embolization. Magnetic nanoparticles is also a good tool for the treatment of water polluted with metal and organic materials.

Keywords

Magnetite, Superparamagnetic Iron Oxide Nanoparticles, Magnetic Targeting, Nanomagnetosols, Magnetic Resonance Imaging.

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Dhanish Joseph ¹, Golda Maria Thomas ¹

Affiliations
1 Nirmala College of Pharmacy Muvattupuzha, Ernakulam, Kerala, IN

Abstract

Bilayer tablet technology is an improved beneficial technology to overcome the shortcomings of the single-layered tablet. The introduction of bilayer tablets into the pharmaceutical industry has enabled the development of pre-determined release profiles of active ingredients and incorporation of incompatible active ingredients into a single unit dosage form. Bilayer tablets provide one of the important design approaches where incompatible drugs, with a different indication, and same drug with different release rate can be incorporated in a single unit. Bilayer tablet is suitable for sequential release of two drugs in combination, and for sustained release tablets in which one Layer is immediately released as initial dose and the second layer is a maintenance dose. Bilayer formulations carry one drug, and deliver each of them without any pharmacokinetic or dynamic interactions, with their individual rate of delivery. Controlled release dosage forms have been extensively used to improve therapy with several important drugs. Use of bilayer tablet is a very different aspect for anti-inflammatory and analgesic drugs. This review discusses various applications of bilayer tablets such as controlling of delivery rate, providing synergic property and agonistic effect, administration of fixed-dose combinations etc. In sustained release tablet formulations, the commonly used functional ingredient is HPMC and in immediate release, the commonly used functional ingredients are Sodium Starch Glycollate, Crospovidone, and Croscarmellose sodium.

Keywords

Bilayer Tablet, Immediate Release, Sustained Release, Super Disintegrant, Release Pattern.

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