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Nangare, Gajanand
- Development and Validation of Rp-hplc Method for the Estimation of Alogliptin in Api and Tablet Formulation
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1 D.S.T.S. Mandal’s College of Pharmacy, Solapur - 413004, Maharashtra,, IN
1 D.S.T.S. Mandal’s College of Pharmacy, Solapur - 413004, Maharashtra,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1791-1794Abstract
The analytical method was developed and validated for determination of Alogliptin in bulk and pharmaceutical dosage forms by High performance liquid chromatography. The separation was carried out on Zorbax SB-Aq (250 x4.6mm,5μ ID) column. The mobile phase consists of 0.1% TFA Water : ACN in the ratio 62:38 at flow rate 1ml/min with diode array detector wavelength at 290nm.The column temperature was adjusted at 30º ± 0.5°C with injection volume 10μl.The retention time of Alogliptin was 3.06min. The linearity of the calibration curve was linear over the concentration range 25-75μg/ml (r2=1). The validation was carried out as per ICH guidelines. The development of method was easy, rapid, linear, precise, accurate and consistent.Keywords
Alogliptin, RP-HPLC, Validation, Method development, 290nm and diode array detector.
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