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Obilineni, Iswarya
- Evaluation of Antihyperlipidemic Activity of Leaves of Cassia Tora
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Authors
Iswarya Obilineni
1,
Jangam Divya Latha
2,
Kamireddy Srikala
2,
Gummadi Asha
3,
Marupilla Amulya
3,
Vaddeswarapu Rajani
2
Affiliations
1 Assistant Professors, KVSR Siddhartha college of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh., IN
2 Assistant Professors, Nirmala College of Pharmacy, Atmakur, Andhra Pradesh., IN
3 IV B Pharmacy Students, Nirmala College of Pharmacy, Atmakur, Andhra Pradesh., IN
1 Assistant Professors, KVSR Siddhartha college of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh., IN
2 Assistant Professors, Nirmala College of Pharmacy, Atmakur, Andhra Pradesh., IN
3 IV B Pharmacy Students, Nirmala College of Pharmacy, Atmakur, Andhra Pradesh., IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 741-744Abstract
Aim: To evaluate the antihyperlipidemic activity of leaves of cassia tora Objective: Hyperlipidemia is a clinical condition causing lethal diseases like atherosclerosis, myocardial infarction etc that ultimately leads to death. Several works have been reported that the extracts of many plants have antihyperlipidemic activity. Cassia tora is used for a long time as a daily vegetable in many countries. It consists of phytochemical constituents like flavonoids which lowers blood cholesterol level. Materials and Methods: Materials used: Antihyperlipidemic activity of Cassia tora was screened by a model, Cholesterol diet induced hyperlipidemia. Marker enzymes like LDH, LDL, VLDL, total protein, total cholesterol, AST, ALP, ALT,SOD, Catalase, LPO and histopathology of myocardium and aorta carried out. Results: Flavonoids of leaves of Cassia tora treated group showed significant decrease in LDL-Cholesterol, total cholesterol, triglycerides, AST, ALT, ALP and increase in HDL cholesterol, albumin, total protein and further was concluded by histopathological studies. Conclusion: From result, it was concluded that flavonoid of leaves of Cassia tora shows antihyperlipidemic activity in the heart of rats.Keywords
Antihyperlipidemic, Hypercholesteremia, Cholesterol-diet, Atherosclerosis, Myocardial infarction.References
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- Production of Naringinase by Using Amla on Solid State Fermentation
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Authors
Affiliations
1 Associate Professor, Department of Biotechnology, Nirmala College of Pharmacy, Atmakuru, Mangalagiri, Guntur., IN
2 Principal, KVSR Siddhartha College of Pharmaceutical Sciences Vijayawada, Andhra Pradesh., IN
3 Principal, Nirmala College of Pharmacy, Atmakur, Andhra Pradesh., IN
4 Assistant Professor, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh., IN
1 Associate Professor, Department of Biotechnology, Nirmala College of Pharmacy, Atmakuru, Mangalagiri, Guntur., IN
2 Principal, KVSR Siddhartha College of Pharmaceutical Sciences Vijayawada, Andhra Pradesh., IN
3 Principal, Nirmala College of Pharmacy, Atmakur, Andhra Pradesh., IN
4 Assistant Professor, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh., IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 3 (2022), Pagination: 1225-1229Abstract
Microbial enzymes are widely used in different pharmaceutical, textile and in leather industries, mainly because of vast availability of sources. They could be genetically modified and are considered as more economical in comparison to plant and animal enzymes. Production of microbial enzymes by application of fermentation involves microbial propagation like bacteria, mold and yeast to get useful product. There are two methods of fermentation used to produce microbial enzymes called submerged fermentation and solid-state fermentation. Submerged fermentation involves the production of enzymes by using microorganisms in a liquid state nutrient media. Solid-state fermentation is the cultivation of microorganisms in solid substrate. Nutrients containing carbon compounds are broken down by the microorganisms, which produce the enzymes either intracellular or extracellular. Industries that use enzymes generated by fermentation are the brewing, wine making, baking, cheese making, dairy, beverages, and cereals. In the present study Asperigillus Niger strain was used to produce the extra cellular naringinase enzyme in nutrient medium containing Amla as a solid substrate. Amla is the chief material for the production maximum Naringinase enzyme. The study also involved in the optimization of various physical parameters like temperature, PH, incubation period, mass of inoculum. The study concluded that pH -5.5, temperature of 28oc, incubation period of 96 hrs and 20% of inoculums for maximum naringinase production.Keywords
Naringinase, Amla, Asperigillus Niger, solid state fermentation, Enzymes.References
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