Research Journal of Pharmacy and Technology

Halah A. Sahib ¹, Mohammed K. Hadi ¹, Maadh Qusay Abdulkadir ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad,, IQ

Abstract

In this work, novel compounds of hydrazones derived from (2,4-dinitrophenyl) hydrazine were synthesized. Benzamides derivatives and sulfonamides derivatives were prepared from p-amino benzaldehyde. Then these compounds were condensed with (2,4-dinitrophenyl) hydrazine through Imine bond formation to give hydrazones compounds. The compounds were characterized using FT-IR (IR Affinity-1) spectrometer, and 1HNMR analyses. The majority of the compounds have a moderate antimicrobial activity against “Gram-positive bacteria staphylococcus Aureus, and staphylococcus epidermidis, Gram-negative bacteria Escherichia coli, and Klebsiella pneumoniae, and fungi species Candida albicans” using concentrations of 250 μg\ml.

Keywords

(2,4-dinitrophenyl) hydrazine, Schiff base, Hydrazone, Amide, Sulfonamides, Antibacterial and Antifungal activity.

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