Research Journal of Pharmacy and Technology

Mon Mon Yee ¹, Mi Mi Khaing ², Khin Than Yee ³, Aye Mya Thidar ¹

Affiliations
1 Newcastle University Medicine Malaysia, Johor,, MY
2 Faculty of Medicine, SEGi University Sibu Clinical Campus, Sarawak,, MY
3 Faculty of Medicine and Health Science, University Malaysia Sarawak,, MY

Abstract

Introduction: Pregnancy is confronted with increased risk for COVID-19 since the expression of immune markers, realized the fact that the immune cells and cytokines, the virtuous understanding of the pathophysiology of the disease reduce maternal deaths. Pregnant women are enfeebled against the immune systems and are at added risk of contracting COVID-19. Indeed, they are at added risk of contracting COVID-19. The studies have proven the similarities between the COVID-19 and pregnancy regard to their immune system marked by a noticeable reduction in lymphocytes and raise in selected proinflammatory cytokines. Purpose: The study aims to conduct a review engine to enhance the knowledge on pathophysiological stirrings of condition in normal pregnancy and COVID-19, which are marked by decreased lymphocytes, NKG2A inhibitory receptors, and increased ACE2, IL-8, IL-10, and IP-10 project the risk for developing COVID-19 in pregnancy. To bring out the awareness on pregnancy vulnerability risk for COVID-19 and its complications. Method: This study is initiated with search engine reviewing previous studies correlating with various aspects of normal pregnancy COVID-19 pathophysiological aspects and COVID attack risk in pregnancy. This study probe through electronic databases such as PubMed, Medline, and Scopus databases using keywords such as Coronavirus Immune marker, Pregnancy Lymphocytes, Natural killer cells, a similar pat physiological condition in pregnancy, and COVID-19, Pregnancy vulnerability risk for COVID-19. Result: Analysed studies have given out fruitful information on pregnancy risk, the corona virus immune markers in pregnancy is seen with reduced lymphocytes, and increase proinflammatory cytokines that depict the similarity in the pathophysiological condition in pregnancy and COVID-19, pave up to pregnancy vulnerability for risk in COVID-19 contraction. Conclusion: This review analysis drawn informative tips for professionals that would be useful in educating patient as a part of preventive measure.

Keywords

Corona virus Immune markers Pregnancy Lymphocytes Natural killer cells, similar pathophysiological condition in pregnancy and COVID-19, Pregnancy vulnerability risk for COVID-19.

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Khin Than Yee ¹, Helmy Bin Hazmi ¹, Tin Moe Nwe ¹, Mya Mya Thwin ², Mon Mon Yee ³, Mi Mi khaing ⁴, Soe Lwin ¹, Myat San Yi ¹

Affiliations
1 Faculty of Medicine and Health Science, University Malaysia Sarawak, Sarawak, MY
2 Medical Faculty, University Sultan Zainal Abidin, Kuala Terengganu, MY
3 Newcastle University Medicine Malaysia, Johor,, MY
4 Faculty of Medicine, SEGi University Sibu Clinical Campus, Sarawak,, MY

Abstract

Introduction: In modern medical education, with its transformational changes, teacher-centered learning is transformed into student-centered learning. This shift has escalated so fast with momentum, and its value in teaching and learning has been evaluated in many ways. In the current scenario, problem-based learning (PBL) is a well-recognized effective method of teaching and learning. The credit goes to McMaster University in Hamilton, Ontario, Canada, for the establishment of PBL. In Malaysia, many medical schools have applied this method in their curriculum, one of which is University Malaysia, Sarawak (UNIMAS), which has also adopted PBL in its undergraduate curriculum since 1996. Purpose: The aim of this study is to determine the students’ acceptance of PBL and its positive and negative impact on their learning. Methodology: It was a cross-sectional study conducted to determine the acceptance of the students of PBL. The study population is selected using convenience sampling of 140 out of 148 pre-clinical year-2 students who were exposed to the PBL method, the focus group discussion (FGD) was conducted based on pre-framed questions to know the impact of PBL on the students’ learning. Results: Results showed that the respondents had the satisfaction and accepted PBL. Sixty students from 6 PBL groups were involved in FGD. Feedback from FGD revealed their difficulties with the conduction of 1st session of PBL, for instance, problems in searching resources, new learning environments and peers from different regions. There were positive responses spelled by the subjects that the PBL has improved their communication skills, critical thinking, and self-esteem. Conclusion: Overall the PBL has proved beneficial evidenced a positive impact on the learning process of medical students.

Keywords

Problem-based learning (PBL), acceptance, impact, focus group discussion (FGD)

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