Research Journal of Pharmacy and Technology

Akshara Ravi ¹, M. Gokul Raj ¹, Sathiavelu Arunachalam ¹, Mythili Sathiavelu ¹

Affiliations
1 School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, IN

Abstract

Marine environment is known for its rich and vast diversity of flora and fauna. It acts as a potential source for a variety of drugs that can cure wide range of diseases like cancer, diabetes. In this article, we have emphasized on the different types of anticancer drugs obtained from the marine biome. The drugs have been tabulated on the basis of their source. Though most of the drugs are being isolated from marine animals, marine microbes and plants also have the capacity to produce metabolites that possess anticancer activities. This review throws light on some of the anticancer drugs isolated from marine microbes, animals and plants as well. When compared to other natural environments, marine environment tops the list by giving most of the drugs to the medical field. The marine environment has become an extraordinary source for extracting anti-cancer drugs. All these drugs have enough potential to be analyzed for their anti-cancer capabilities. This article highlights all the major marine mined drugs which are being used in treating cancer. Few of these drugs are into existence but few are still under clinical trials. Lots of research needs to be put into this field so as to obtain effective anticancer drugs.

Keywords

Cancer, Anticancer Drugs, Marine Environment.

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Ranjitha Dhevi V. Sundar ¹, Mythili Sathiavelu ²

Affiliations
1 School of Biosciences and Technology, VIT University,Vellore-632014, Tamil Nadu, IN
2 School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore–632014, Tamil Nadu, IN

Abstract

The aim of this work is to investigate and compare the phytochemical screening, antioxidant and antimicrobial activities of plant crude extracts from leaves of four different medicinal plants Mukia maderaspatana, Cissus quadrangularis, Portulaca quadrifida, Pisonia Alba. Methanol and Petroleum ether solvent were used to prepare the crude extracts from leaves. Antioxidant and antimicrobial activities of different crude extracts were determined by DPPH method and agar disc diffusion method. Antibacterial activity was carried out against five different organisms (Escherichia coli (MTCC: 1687), Bacillus cereus (MTCC: 0430), Klebsiella pneumoniae (MTCC: 7028), Staphylococcus aureus(MTCC: 3160), Proteus mirabilis (MTCC: 3310). And the antifungal activity against A.niger (MTCC 281) and A.flavus (MTCC 10938). All the extracts showed a promising antibacterial activity. Hence, the outcomes of the present research suggest that the potential antioxidant and antimicrobial activity of these different plants may be responsible for its wide traditional use as medicine.

Keywords

Medicinal Plants, Antimicrobial Activity, Antioxidant, DPPH, Phytochemical Analysis.

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Saranya Shankar ¹, Mythili Sathiavelu ¹

Affiliations
1 School of Bioscience and Technology, Vellore Institute of Technology, Vellore-632014, Tamil Nadu, IN

Abstract

The present study aims to analyze the phytochemicals, antioxidant, antimicrobial and in vitro anti-inflammatory activity of three different plant leaf extracts such as Pithecellobium dulce, Sesbania grandiflora and Lablab purpureus belongs to the family fabaceae. Qualitative phytochemical screening of different plants leaf powder confirmed the presence of tannins, alkaloids, phenols, terpenoids, flavonoids and anthraquinone glycosides. Methanolic leaf extract of Sesbania grandiflora plant possess highest total phenolic content of about 14.21 ± 0.011mg of GAE/g of extract whereas, Petroleum ether leaf extract of Lablab purpureus plant exhibits highest total phenolic content of about 11.45 ± 0.002 mg of GAE/g of extract. In DPPH assay, methanol leaf crude extract demonstrated 86±1.77% antioxidant activity in Sesbania grandiflora at 150μg/ml concentration. Whereas petroleum ether leaf crude extract demonstrated 82±1.66% antioxidant activity in Lablab purpureus at 150μg/ml concentration and in reducing power assay, both the methanol and petroleum ether leaf crude extract demonstrated 85±1.73% and 88±1.92% antioxidant activity in Sesbania grandiflora at the same concentration 150μg/ml. In egg albumin denaturation assay, both the methanol and petroleum ether leaf crude extract exhibited 78±1.38% and 81±1.79% anti-inflammatory activity in Lablab purpureus at the same 300μg/ml concentration. When compared to all plants extracts in antibacterial activity methanol leaf extract of Sesbania grandiflora demonstrated clear zone of inhibition against test microorganisms against five studied pathogens. When compared to all plants extracts in antifungal activity methanol leaf extract of Sesbania grandiflora demonstrated clear zone of inhibition against test pathogen Aspergillus niger. Results of this study conclude that the three different medicinal plant leaf extracts contains significant potential for pharmaceutical applications.

Keywords

Medicinal Plants, Phytochemicals, Antioxidant Activity, Antibacterial Activity, Antifungal Activity, In vitro Anti-Inflammatory Activity.

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