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Nayak, Prashant
- Formulation and Evaluation Ungual Drug Delivery System of Antifungal Agent for Nail Disorders
Abstract Views :155 |
PDF Views:1
Authors
R. Narayana Charyulu
1,
D. S. Sandeep
1,
Abhishiktha Alva
1,
Divya Rao
1,
Prashant Nayak
1,
Jobin Jose
1,
K. C. Bahrath Raj
2
Affiliations
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
2 Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte, Mangalore, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 10, No 3 (2017), Pagination: 869-872Abstract
Fungal infections affecting nails are commonly seen around the world. The effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Nail permeability is however quite low and limits topical therapy to early/mild disease states such as onychomycosis (fungal infections of the nail). The current research aims at ungual drug delivery system as an effective treatment in nail infections. The formulations of nail lacquer were made with Amorolfine as antifungal agent using different concentration of polymer Eudragit RL 100 (ERL 100). Among 6 formulations, formulation F5 and F6 showed very good physical characteristics like viscosity, water resistance, stability, drying time, smoothness as compared to other formulations. The zone of inhibition of antifungal activity showed desired results (F5 and F6).Keywords
Nail Lacquer, Polymer, Ungual Drug Delivary, Viscosity.- Oral Dispersible Films, Novel Technology for the Delivery of Drugs
Abstract Views :182 |
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Authors
Affiliations
1 Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore – 575018, IN
1 Department of Pharmaceutics, N.G.S.M. Institute of Pharmaceutical Sciences, NITTE Deemed to be University, Paneer, Deralakatte, Mangalore – 575018, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 1 (2019), Pagination: 425-428Abstract
Various dosage forms have been introduced in the recent days in the field of pharmaceutical technology. Transdermal patch is a technique from which a new drug delivery system that is oral dispersible film was developed. Oral dispersible films when they placed on mouth or oral cavity, they disintegrate or dissolve within a minute. Even though in a solid dosage form it doesn’t require chewing or drinking of water, which enhances the patient compliance. There are number of ingredients are used to formulate oral dispersible patches, like active pharmaceutical ingredients, polymers, flavouring agents, colouring agents etc, in which we can regard polymer as important ingredient which helps to form the film. Usually hydrophobic polymer are used for oral dissolving films which breaks down on the tongue or buccal cavity and then drug will go to systemic circulation. Fast disintegrating property, good mechanical property like mouth dissolving property of film can be achieved by water soluble polymer. Moreover in oral dispersible films, accurate and effective dosing can be accomplished in a safe manner.Keywords
Oral Dispersible Films, Hydrophilic Polymers, Plasticizers, Solvent Casting.References
- Irfan M, Khan A. orally disintegrating film: A modern Expansion in drug delivery system. 2016; 24(5):537-546.
- Scarpa M, Stegemann S, Hsiao WK. Orodispersilble films: Towards drugs delivery in special population. International Jornal of Pharmaceutics. 2017;523(1):327-335.
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- Hoffmann M E, Beitenbach A, Breitkreutz J. Advances in orodispersable films for drug delivery. Expert opinion in drug deliv. 2011;8(3):299-316
- Jose J, Netto G. Role of solid lipid nanoparticles as photoprotective agents in cosmetics. journal Cosmetic Dermatology. 2018; 00:1–7. https://doi.org/10.1111/jocd.12504.
- Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: Innovations in formulation and technology. International Journal of Pharmaceutical science review and research. 2011;9(2): 50-57.
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- Joshua JM, Hari R, Jyothish KF et al. Fast dissoliving oral thin films an effective dosage form for quick release. International Journal of Pharmaceutical Sciences Review and Research. 2016;38(1):282-289
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- Mashru RC, Sutariya VB, Sankalia MG, Parikh PP. Development and evaluation of fast dissolving film of salbutamol sulphate. Drug Develoment and Industrial Pharmacy. 2005;31:25–34.
- Jose J, Charyulu RN. Prolonged drug delivery system of an antifungal drug by association with polyamidoamine dendrimers. International Journal of Pharmaceutical Investigation.2016; 6(2):123–127.
- Deepthi S, Jose, J. Novel hydrogel-based ocular drug delivery system for the treatment of conjunctivitis. International Ophthalmology. 2018; https://doi.org/10.1007/s10792-018-0955-6.
- Ali MS, Vijendar C, Kumar SD, Krishnaveni J. Formulation and evaluation of fast dissolving oral films of diazepam. Journal of pharmacovigilance. 2016;4:210.
- Synthesis and Antimicrobial Evaluation of Some Novel 1,5 Benzodiazepine Derivatives Derived from Pyrrolyl Chalcones
Abstract Views :152 |
PDF Views:0
Authors
Pankaj Kumar
1,
Abhishek Kumar
1,
Jean Sandra Pinto
1,
Sachin A. Kumbar
1,
Nanditha Bhat
1,
Prashant Nayak
2
Affiliations
1 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
2 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
1 Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
2 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangaluru, Karnataka,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1811-1814Abstract
The α,β unsaturated ketone 3-(2,4-dimethyl-1H-pyrrol-3-yl)-1-phenylprop-2-en-1-onederivatives were treated with benzene-1,2-diamine to obtain 2-(2,4-dimethyl-1H-pyrrol-3-yl)-4-phenyl-2,3-dihydro-1H-benzo[b][1,4]diazepine derivatives. These synthesized compound were characterized by IR, 1H NMR, and mass spectroscopy. These synthesized molecules were evaluated for invitro antimicrobial activity. All The synthesized compounds, showed potent anti-microbial activity as compare to reference drug. In these study the synthesized were docked with Type IIA topoisomerases 2XCT using glide dock program and binding affinity were predicted for the synthesized compounds. The compound AP8 and AP9 have shown more active as per binding energy.Keywords
Benzodiazepines, Antimicrobial, Docking, Topoisomerases, o-Phenylenediamine.References
- Ilango SS, Remya PU, Ponnuswamy S. Synthesis, and antimicrobial activity of novel 1,5-benzodiazepines. Indian. J. Chem., 2013; 52B: 136-140.
- De Sarro G, Gitto R, Rizzo M., Zappia M., De Sarro A. 1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice. Gen. Pharmacol.1996; 27(6):935-941. DOI: 10.1016/0306-3623(95)02147-7
- Najafi N, Pirali M, Dowlatabadi R, Bagheri M, Rastkari N, Abdollahi M. Synthesis and analgesic and anti-inflammatory properties of new benzodiazepine derivatives. Pharmaceutical Chemistry Journal. 2005; 39(12):641-3. DOI :10.1007/s11094-006-0036-4
- Tardibono LP, Miller MJ. Synthesis and anticancer activity of new hydroxamic acid containing 1,4 benzodiazepines. Org. Lett., 2009; 11(7):1575-1578. DOI :10.1021/ol900210h
- Burmaoglu S, Algul O, Gobek A, Aktas AD, Ulger M. Aslan, G. Design of potent fluoro-substituted chalcones as antimicrobial agents. J. Enzyme. Inhib. Med. Chem., 2107; 32(1):490-495. DOI: 10.1080/14756366.2016.1265517
- Hans RH, Guantai EM., Lategan C, Smith PJ, Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg. Medicinal. Chem Lett .2010; 20(3):942-944. DOI: 10.1016/j.bmcl.2009.12.062
- Syam S, Abdelwahab SI, Al-Mamary MA, Mohan S. Synthesis of chalcones with anticancer activities. Molecules. 2012;17(6):6179-95. DOI: 10.3390/molecules17066179
- Tavadyan LA, Manukyan ZH, Harutyunyan LH, Musayelyan MV, Sahakyan AD, Tonikyan HG. Antioxidant properties of selenophene, thiophene and their aminocarbonitrile derivatives. Antioxidants. 2017;6(2):22. DOI: 10.3390/antiox6020022
- Nowakowsk Z. A review of anti-infective and anti-inflammatory chalcones. Eur. J. Med. Chem. 2007, 42(2):125-137. DOI: 10.1016/j.ejmech.2006.09.019
- Kumar P, Fernandes J, Kumar A. Synthesis and Antimicrobial Evaluation of Substituted Oxazolidinones Moieties. Res. J. Pharm. Technol. 2017;10(1):98-100. DOI: 10.5958/0974-360X.2017.00023.3
- Kumar P, Kumar A, Nayak P. Synthesis and Antimicrobial evaluation of Some novel Mercapto Pyrimidine via Pyrrole chalcone. Res. J. Pharm. Technol. 2018;11(7):2765-7. DOI: 10.5958/0974-360X.2018.00511.5