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Pise, Shilpa
- Formulation and Evaluation of Chronomodulated Pulsatile Drug Delivery System for Nocturnal Hyperacidity
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1 Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), IN
1 Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), IN
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Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1449-1454Abstract
Introduction: Chronomodulated pulsatile drug delivery system is basically time-controlled drug delivery system in which the release of drug in the body is allowed to match with circadian rhythm with controlled lag time. Aim and Objective: The objective of this work was to develop and evaluate oral pulsatile tablet of Pantoprazole sodium for the treatment of nocturnal hyperacidity. Pulsatile drug delivery system for Pantoprazole sodium was formulated initially as a core tablet followed by press coated. Five different compositions of the core tablet were prepared by using cross carmellose super disintegrant. Base on drug content and dissolution time F5 formulation optimised and proceeds for press coating. Five different compositions of press coating were prepared and evaluated for in vitro drug release. Result: The formulation C4 achieved a maximum of 99.65% cumulative drug release over a period of 3hr. 30 min. Lag time for C4 formulation was found to be 2 hr. It means that the system was found to be satisfactory in terms of drug release after a lag time. Conclusion: Since the developed formulation when taken at bedtime, the tablet would be expected to release the drug at midnight which provides better control with the nocturnal hyperacidity.Keywords
Pulsatile drug delivery, Nocturnal hyperacidity, Chronomodulated drug design, Pantoprazole
References
- Bisht R. Chronomodulated drug delivery system: A comprehensive review on the recent advances in a new sub-discipline of chronopharmaceutics. Asian J Pharm. 2011;5(1):1–8.
- Singh N, Gill V, Gill P, Singh S. Chronopharmaceutical drug delivery system-a guided therapy. Int Res J Pharm Appl Sci. 2013;3(4):84–7.
- Robinson M, Rodriguez-Stanley S, Ciociola AA, Filinto J, Zubaidi S, Miner PB, et al. Control of nocturnal gastric acidity: A role for low dose bedtime ranitidine to supplement daily omeprazole. Dig Dis Sci. 2002;47(2):265–73.
- Timmakondu S. Chronomodulated delivery of Pantoprazole for nocturnal hyperacidity. Int J Pharm Sci Nanotech. 2015;8(4):3038–44.
- Pensabene L, Davidson G. Proton pump inhibitors. Esophageal Gastric Disord Infancy Child. 2017;56(3):995–1013.
- Jain D, Raturi R, Jain V, Bansal P, Singh R. Recent technologies in pulsatile drug delivery systems. Biomatter. 2011;1(1):57–65.
- Aravind PM, Rathnanand M, Madhu Kumar C. Stability enhancement of proton pump inhibitor in stomach: Formulation and in vitro evaluation of stabilized proton pump inhibitor. Asian J Pharm Clin Res. 2017;10(5):88–92.
- Kharwade RS, More SM, Mahajan UN. Formulation and evaluation of gastroretentive floating tablet using Hibiscus rosa-sinensis mucilage. Asian J Pharm Clin Res. 2017;10(3):444–8.
- Anusha V, Shanthi G KD. Formulation and Evaluation of Chronomodulated Pulsatile Drug Delivery System of Salbutamol Sulphate. Int J Pharm Res Sch. 2014;5(1):671–7.
- Ravichandiran V, Suba V, Senthilnathan B, Rajachandrika K, Padmapriya S, Saraswathy T, et al. Pulsatile drug delivery system. Biomed Pharmacol J. 2009;2(2):227–34.
- Bhusnure OG, Gholve SB, Giram PS, Thonte SS, Kazi PA, Bhange MA. Role of Superdisintegratings in Fast Dissolving Tablets. Int J Pharm Pharm Res. 2015;4(2):263–81.
- Garg AK, Kumar A, Rani S, Singh M, Sharma A, Kumar R. Formulation and evaluation of chronotherapeutic pulsatile drug delivery system containing rabeprazole sodium. J Appl Pharm Sci. 2017;7(2):093–100.
- Arora S, Ali J, Ahuja A, Baboota S, Qureshi J. Pulsatile drug delivery systems: An approach for controlled drug delivery. Indian J Pharm Sci. 2006;68(3):295–300.
- Jagdale SC, Suryawanshi VM, Pandya S V., Kuchekar BS, Chabukswar AR. Development of press-coated, floating-pulsatile drug delivery of lisinopril. Sci Pharm. 2014;82(2):423–40.
- WHO. Guidelines for Stability Testing of Pharmaceutical Products Containing Well Established Drug Substances in Conventional Dosage Forms. World Heal Organ Tech Rep Ser. 1996;(863):65–80.
- Kharwade RS, Mahajan NM. Formulation and Evaluation of Nanostructured Lipid Carriers Based Anti-Inflammatory Gel for Topical Drug Delivery System. Asian J Pharm Clin Res. 2019;12(4):286–91.
- Rahman SM, Saha T, Masum ZU, Chowdhury JA. Evaluation of Physical Properties of Selected Excipients for Direct Compressible Tablet. Bangladesh Pharm J. 2017;20(1):34–8.
- Rane AB, Gattani SG, Kadam VD, Tekade AR. Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers. Chem Pharm Bull. 2009;57(11):1213–7.
- Solunke RS, Khade GA, Deshmukh RV, Kore KJ. Development and evaluation of pantoprazole sodium floating gel. Research J. Pharm. and Tech. 2020; 13(2): 682-6.
- Putikam JK, Rao YN, Anjaneyulu V, Undralla VK, Formulation and evaluation of metoprolol succinate extended release tablet. Research J. Pharm. and Tech. 2012; 5(1):75-8.
- Shriniwasa DS, Narayana CR, Satyanarayana DS. Formulation and in vitro comparative evaluation of orodispersible tablets of Pantoprazole. Research J. Pharm. and Tech. 2015; 8(10):1389-93.
- Gangane PS, Ghughuskar SH, Mahapatra DK, Mahajan NM. Evaluating the role of Celosia argentea powder and fenugreek seed mucilage as natural super-disintegrating agents in gliclazide fast disintegrating tablets. Int J Curr Res Rev. 2020;12(17):101–8.
- Patil S, Jagdale S, Kela S,Divekar S. Formulation andevaluation of xanthum gum based floating tablet of Tramadol. Int J Curr Res Rev. 2012;4(17):172–80.
- Flaxseed Mucilage Hydrogel Based Floating Drug Delivery System: Design and Evaluation
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Authors
Affiliations
1 B.Pharm. Final Year Student, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur, University, Nagpur, (MS), IN
2 Asst. Professor, Pharmacology Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), IN
3 Asst. Professor, Regulatory Affair Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, IN
4 Professor, Quality Assurance Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), IN
5 Asst. Professor, Pharmaceutic Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, IN
1 B.Pharm. Final Year Student, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur, University, Nagpur, (MS), IN
2 Asst. Professor, Pharmacology Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), IN
3 Asst. Professor, Regulatory Affair Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, IN
4 Professor, Quality Assurance Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS), IN
5 Asst. Professor, Pharmaceutic Department, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Rashtrasant Tukadoji Maharaj, Nagpur University, Nagpur, (MS),, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 4 (2022), Pagination: 1549-1554Abstract
Natural polymer-based plant polysaccharides and proteins have been most widely explored as an adjuvant in the dosage form formulation. Here we design a novel gastro-retentive floating tablet, based on a polysaccharide material from Flaxseed (Linum usitatissimum L.) for Domperidone. After oral administration; Domperidone showed good solubility in acidic pH but significantly reduced solubility in alkaline medium. So that to increase the absorption and bioavailability of Domperidone, it is necessary to increase the retention time in the upper part of the Gastrointestinal tract (GIT) by developing a floating sustained drug delivery system. The directly compressible floating tablets of domperidone were formulated using varying amount of hydroxypropyl methylcellulose K 100 M (HPMC K100 M), Carbopol 934 and Flaxseed mucilage. Hardness, friability, weight variation, thickness, disintegration time of tablet formulations were within acceptable limits. The overall results explained that the optimized formulation F5 prepared by the exact ratio of Flaxseed mucilage, HPMC K100 M, Carbopol, could be more efficient on floating and sustained release of Domperidone in the upper part of GIT as compared to the tablets prepared by using HPMC K100 M and Carbopol 934 only. These findings indicated that Flaxseed can be used to develop novel gastro-retentive sustained release drug delivery system with the double advantage of sustained drug release at the upper part of GIT.Keywords
Floating tablet, Flaxseed mucilage, Sustained release, Gastroretentive, Drug release kinetics.References
- Abuhelwa AY, Williams DB, Upton RN, Foster DJR. Food, gastrointestinal pH, and models of oral drug absorption. Eur J Pharm Biopharm [Internet]. 2017; 112: 234–48. Available from: http://dx.doi.org/10.1016/j.ejpb.2016.11.034
- Davies P, Prowle M. Domperidone. Br Med J. 1985;290(19):241–2.
- Kharwade RS, Mahajan UN. Enhancement of dissolution and bioavailability of Ezetimibe by spray dried microparicles using HP- β - Cyclodextrin Polymer. 2017;8(8):3293–301.
- Rouge N, Leroux JH, Cole ET, Doelker E, Buri P. Prevention of the sticking tendency of buoyant minitablets filled into hard gelatine capsules. Eur J Pharm Biopharm 1997; 43:165-71.
- Lee JH, Park TG, Choi HK. Development of oral drug delivery system using floating microspheres. J Microencapsul 1999; 16: 715-29.
- Hilton AK, Deasy PB. Invitro and invivo evaluation of an oral sustained‐release floating dosage form of amoxicillin trihydrate. Int J Pharm .1992; 86: 79‐88.
- Chavanpatil M, Jain S, Chaudari S, Shear R, Vavia P. Development of sustained release gastro-retentive drug delivery system for Ofloxacin: Invitro and invivo evaluation. Int J Pharm. 2005; 304: 178‐84.
- Khullar P, Khar RK, Agrawal SP. Evaluation of hydrogel-based controlled- release niacin tablets. Drug Dev. Ind. Pharm. 1998; 24 (5): 479–83.
- Robinson JR, Erikson SP. Theoretical formulation of sustained-release dosage forms. J. Pharm Sci. 1966; 55(11): 1254-63.
- Pawar VK, Kansal S, Garg G, Awasthi R, Singodia D, Kulkarni GT. Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems. Drug Deliv. 2011;18(2): 97–110.
- Pandit A, Shikshan J, Mandal P. Study of disintegration properties of mucilage from Linum. 2018; (September).
- Sajid KS, Kamran AC, Rooh U. Formulation development and evaluation of domperidone sustained release matrix tablets by two different methods using guar gum as a sustaining agent. World App Sci J. 2013; 25 (12): 1704-12.
- Khan MA, Saeed M, Badshah A, Muhammad N, Khan J, Khan FA, et al. Design, formulation, optimization and evaluation of sustained-release tablets of domperidone. Afr J Pharm Pharmacol 2011; 5(16): 1882-7.
- Baumgartner S, Kristel J, Vreer F, Vodopivec P, Zorko B. Optimization of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm. 2000; 195: 125- 35.
- Ziolkovska A. Laws of flaxseed mucilage extraction. Food Hydrocoll [Internet]. 2012; 26(1): 197–204. Available from: http://dx.doi.org/10.1016/j.foodhyd.2011.04.022
- Kishk YF. Optimization of flaxseed mucilage extraction and its functional characteristics. Ann Agric Sci Moshtohor. 2018;(November 2004).
- Sheikh FA, Hussain MA, Ashraf MU, Haseeb MT, Farid-ul-Haq M. Linseed hydrogel-based floating drug delivery system for fluoroquinolone antibiotics: Design, in vitro drug release and in vivo real-time floating detection. Saudi Pharm J [Internet]. 2020;28(5):538–49. Available from: https://doi.org/10.1016/j.jsps.2020.03.005
- Kharwade RS, Vyavhare NS, More SM. Formulation of mucoadhesive tablet by using Aegle Marmelos. Int J Appl Biol Pharm Technol. 2011; 2(1): 154–61.
- Shunmuga VJ, Lakshmanan P, Basker RD. Formulation development and characterization of Hibiscus rosa-sinesis dry leaves mucilage as a smart polymer for pharmaceutical use. Int J App Rea Nat Pro. 2015; 8 (2):28-36.
- Srivastava P, Malviya R. Extraction, Characterization and Evaluation of Orange Peel Waste Derived Pectin as a Pharmaceutical Excipient. Nat Prod J. 2011; 1(1): 65–70.
- Kharwade RS, More SM, Mahajan UN. Formulation and evaluation of gastroretentive floating tablet using Hibiscus rosa-sinensis mucilage. Asian J Pharm Clin Res. 2017;10(3): 444–8.
- Dey S, Dutta S, Mazumder B. Formulation and evaluation of floating matrix tablet of atenolol for gastro-retentive drug delivery. Int J Pharm Pharm Sci. 2012; 4(3): 433-7.
- Sawjanya K, Shobha Deepthi K, Bharathi A. Formulation and evaluation of gastro-retentive floating matrix tablets of Nevirapine. Int J Pharm Pharm Sci. 2012; 4(5): 368-75.
- Upadhyay P, Upadhyay S. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. J Appl Pharm Sci. 2011; 1(6): 186–90.
- Higuchi HT. Mechanism of sustained action medication. Theoretical analysis of the rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963; 52: 1145-9.
- Peppas NA, Sahlin JJ. A, A simple equation for description of solute release. III. Coupling of diffusion and relaxation. Int. J. Pharm., 1989; 57: 169–71.