Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Jain, Sourabh
- Evaluation of Toxicity and Antidiabetic Activity of Ethanolic Extract of Flowers of Moringa Oleifera Against Dexamethasone Induced Hyperglycemia in Albino Wistar Rats
Abstract Views :91 |
PDF Views:0
Authors
Affiliations
1 College of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), IN
1 College of Pharmacy, Dr. A.P.J. Abdul Kalam University, Indore (M.P.), IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 2 (2022), Pagination: 517-524Abstract
Diabetes is a defect in the ability of the body to convert glucose (sugar) to energy. Glucose is the main source of energy in our body. When food is digested it is metabolized into fats, proteins, or carbohydrates. Glucose is then transferred to the blood and is used by the cells for energy production. To investigate the antidiabetic effect ethanolic extracts of flowers of Moringa oleifera against dexamethasone-induced insulin resistance in wistar albino rats. To study the antidiabetic effect, flowers of Moringa oleifera were collected and authenticated, extracted and investigated for acute toxicity and dexamethasone induced hyperglcemia. The animals treated with EEMOF at a dose of 100mg/kg and 200mg/kg prevented the development of hyperglycemia, hypercholesteremia and hypertriglyceridemia in dexamethasone induced insulin resistance models. Oral administration of Moringa oleifera 100mg/kg and 200mg/kg reduces serum glucose, triglyceride, total cholesterols and LDL concentration and improve the concentration of HDL in dexamethasone administered rats. The lignin Moringa oleifera showed significant anti-diabetic effect in rats after oral administration. The present study demonstrated that Moringa oleifera could be useful in Management of diabetes associated with abnormalities in lipid profiles. Further study need to isolate, identify the active compounds and find out the possible mechanism of actions.Keywords
Moringa oleifera, Dexamethasone, Hyperglycemia, Ethanolic Extract.
References
- Gisela Wilcox. Insulin and Insulin Resistance. Clin Biochem Rev. 2005 May; 26(2): 19– 39.
- Dongare, S. S., Maske, A. P., Patil, S. M., Umbare, R. P., and Mate, G. S. Antidiabetic Activity of Marsilea quadrifolia linn in alloxan-diabetic rats. Research Journal of Pharmacognosy and Phytochemistry. 2009; 1(1): 15-17.
- Radhika, K., Kumaravel, B., Thamizhiniyan, V., and Subramanian, S. Biochemical evaluation of antidiabetic activity of Piper betel leaves extract in alloxan-induced diabetic rats. Asian Journal of Research in Chemistry. 2013; 6(1): 76-82.
- Macharla, S. P., Goli, V., and Nath, A. R. Antidiabetic Activity of Bambusa arundinaceae Root Extracts on Alloxan Induced Diabetic Rats. Asian Journal of Research in Pharmaceutical Science. 2012; 2(2): 73-75.
- World Health Organization. Obesity: Preventing and Managing the Global Epidemic Report of a WHO Consultation Technical Report Series. World Health Organization, Geneva 2000.
- Vengal Rao, P., Krishnamurthy, P. T., Dahapal, S. P., and Chinthamaneni, P. K. An updated review on “Miracle tree”: Moringa oleifera. Research Journal of Pharmacognosy and Phytochemistry. 2018; 10(1): 101-108.
- Patil, S. R., Patil, M. B., Kumar, R., and Paschapur, M. S. Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats. Research Journal of Pharmacognosy and Phytochemistry. 2009; 1(1): 59-63.
- Ramachandran, C., Peter, K. V., and Gopalakrishnan, P. K. Drumstick (Moringa oleifera): a multipurpose Indian vegetable. Economic Botany. 2009; 276-283.
- Vaishnav, A., Chandy, A., Jhade, D., and Rai, S. Pharmacognostical and Preliminary Phytochemical Studies on Moringa olifera Leaves. Research Journal of Pharmacognosy and Phytochemistry. 2011; 3(6): 272-274.
- Pasha, S., Khaleel, M., and Som, S. Evaluation of Adaptogenic Activity of Moringa oleifera Lam. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(3): 243-247.
- Rastogi, T., Bhutda, V., Moon, K., Aswar, P. B., and Khadabadi, S. S. Comparative studies on anthelmintic activity of Moringa oleifera and Vitex negundo. Asian Journal of Research in Chemistry. 2009; 2(2): 181-182.
- Desai, S. A., Darji, D., and Makwana, M. In-Vitro Anti Bacterial Activity of Water Extract of Moringa oleifera Leaf Stalk. Research Journal of Pharmacognosy and Phytochemistry. 2011; 3(6): 297-299.
- Pasha, S., Khaleel, M., and Som, S. Evaluation of Adaptogenic Activity of Moringa oleifera Lam. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(3): 243-247.
- Manjula, B., Hunasagi, R., and Shivalinge, G. K. Anti-Obesity Activity of Ethanolic Extract of Moringa oleifera Seeds In Experimental Animals. Research Journal of Pharmacology and Pharmacodynamics. 2011; 3(6): 318-328.
- Pasieka, A. M., and Rafacho, A. Impact of glucocorticoid excess on glucose tolerance: clinical and preclinical evidence. Metabolites. 2016; 6(3): 24.
- Geer, E. B., Islam, J., and Buettner, C. Mechanisms of glucocorticoid-induced insulin resistance: focus on adipose tissue function and lipid metabolism. Endocrinology and Metabolism Clinics. 2014; 43(1): 75-102.
- Rosenthaler, L. Chemical investigations of Plants. G. Bell and Sons, London. 1930; 23-29: 119-132.
- Kokate C.K., Purohit A.P., and Gokhale S.B. Pharmacognosy; 23 ed., Nirali prakashan: 2006: pp 493-497.
- Kokate, C. K. Practical Pharmacognosy. Vallabh Prakashan, New Delhi, 4, 1994: 110-111.
- OCDE 423, 2001: OECD guideline for testing of chemicals. Acute Oral Toxicity, Pg. 01-14.
- OECD, 2008. Guideline for the testing of chemicals. Repeated dose 28-day oral toxicity study in rodents (407). 3rd October 2008.
- Bain, B. J., Lewis, S. M., and Bates, I. Basic haematological techniques. Dacie and Lewis Practical Haematology. 2006; 4: 19-46.
- Karmakar, R., Bhattacharya, R., and Chatterjee, M. Biochemical, haematological and histopathological study in relation to time-related cadmium-induced hepatotoxicity in mice. Biometals. 2000; 13(3): 231-239.