Toxicology International (Formerly Indian Journal of Toxicology)

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Kolaviron and Garcinia kola Attenuate Homocysteine-Induced Arteriosclerosis and Cardiotoxicity in Wistar Rats


Affiliations
1 Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria
2 Department of Veterinary Medicine, University of Ibadan, Nigeria
3 Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria
     

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Sixty male Wistar rats were divided into six groups of 10 rats each. Group I was the control. Group II received homocysteine (Hcy) (200 mg/kg body weight) alone daily for 14 days. Rats in groups III and IV received Kolaviron orally at 100 and 200 mg/kg respectively, in addition to Hcy. Rats in groups V and VI received Garcinia kola (GK) orally (100 and 200 mg/ kg respectively) in addition to Hcy (200 mg/kg) for a period of 14 days. The results showed that Hcy caused a reduction in heart rate, shortened QT and QTc intervals together with low voltage QRS which were reversed by Kolaviron (100&amp;200 mg/kg body weight) and Garcinia kola (100&200 mg/kg body weight). Hcy alone also caused a significant (p<0.05) increase in MDA, H2O2 generation, Xanthine oxidase, Myeloperoxidase, Lactate dehydrogenase (LDH), Creatinine kinase cardiac specific (CK-MB) and nitrite with a significant (p<0.05) reduction in non-enzymic and enzymic antioxidants such as Reduced glutathione (GSH), Glutathione peroxidase (GPx), Glutathione-s-transferase (GST), Superoxide dismutase (SOD) and Catalase (CAT) coupled with a significantly high serum values of total cholesterol, triglycerides and low density lipoproteins (LDL) and a significant reduction in (p<0.05) high density lipoprotein (HDL) cholesterol. Overall, co-administration of Hcy with Garcinia kola at 200 mg/kg body weight showed a better cardioprotective and antiatherosclerotic effect on (Hcy)-induced cardiotoxicity and atherosclerosis than Kolaviron in this study.

Keywords

Homocysteine (HCY), Garcinia kola, Kolaviron, Anti-Atherosclerosis, ECG Changes.
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  • Kolaviron and Garcinia kola Attenuate Homocysteine-Induced Arteriosclerosis and Cardiotoxicity in Wistar Rats

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Authors

A. A. Oyagbemi
Department of Veterinary Physiology, Biochemistry and Pharmacology, University of Ibadan, Nigeria
T. O. Omobowale
Department of Veterinary Medicine, University of Ibadan, Nigeria
E. O. Farombi
Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria

Abstract


Sixty male Wistar rats were divided into six groups of 10 rats each. Group I was the control. Group II received homocysteine (Hcy) (200 mg/kg body weight) alone daily for 14 days. Rats in groups III and IV received Kolaviron orally at 100 and 200 mg/kg respectively, in addition to Hcy. Rats in groups V and VI received Garcinia kola (GK) orally (100 and 200 mg/ kg respectively) in addition to Hcy (200 mg/kg) for a period of 14 days. The results showed that Hcy caused a reduction in heart rate, shortened QT and QTc intervals together with low voltage QRS which were reversed by Kolaviron (100&amp;200 mg/kg body weight) and Garcinia kola (100&200 mg/kg body weight). Hcy alone also caused a significant (p<0.05) increase in MDA, H2O2 generation, Xanthine oxidase, Myeloperoxidase, Lactate dehydrogenase (LDH), Creatinine kinase cardiac specific (CK-MB) and nitrite with a significant (p<0.05) reduction in non-enzymic and enzymic antioxidants such as Reduced glutathione (GSH), Glutathione peroxidase (GPx), Glutathione-s-transferase (GST), Superoxide dismutase (SOD) and Catalase (CAT) coupled with a significantly high serum values of total cholesterol, triglycerides and low density lipoproteins (LDL) and a significant reduction in (p<0.05) high density lipoprotein (HDL) cholesterol. Overall, co-administration of Hcy with Garcinia kola at 200 mg/kg body weight showed a better cardioprotective and antiatherosclerotic effect on (Hcy)-induced cardiotoxicity and atherosclerosis than Kolaviron in this study.

Keywords


Homocysteine (HCY), Garcinia kola, Kolaviron, Anti-Atherosclerosis, ECG Changes.

References





DOI: https://doi.org/10.22506/ti%2F2016%2Fv23%2Fi3%2F146718