Open Access
Subscription Access
Open Access
Subscription Access
Biochemical Alterations Following Repeated Intramuscular Administration of Cefquinome in Cow Calves during its Safety Assessment
Subscribe/Renew Journal
The present study was carried out to investigate biochemical alterations induced after repeated intramuscular administration of cefquinome at the dose rate of 2 mg.kg-1 body weight in five healthy cow calves during its safety assessment study. Blood samples were collected before administration of the drug which served as control (day 0). After administration of drugs, blood samples were collected at day 1st, 2nd, 3rd, 4th, 5th and 6th from jugular vein into vacutainers without K3EDTA for serum biochemical parameters (serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), serum lactate dehydrogenase (LDH), serum alkaline phosphatase (AKP), serum acid phosphatase (ACP) and serum bilirubin) analysis. The results of the study clearly demonstrated that repeated intramuscular administration of cefquinome in therapeutic dose produced non-significant (p<0.05) difference in values of serum biochemical parameters in cow calves when compared with control values (0 day). Lack of clinical signs of adverse reactions and absence of significant difference in serum biochemical parameters following intramuscular administration of cefquinome, may open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in cow calves.
Keywords
Cefquinome, Cow Calves, Safety Study, Cephalosporin, Antibiotic.
User
Subscription
Login to verify subscription
Font Size
Information
- Aarestrup F.M and Skov RL. Evaluation of ceftiofur and cefquinome for phenotypic detection of methicillin resistance in Staphylococcus aureus using disk diffusion testing and MIC determinations. Journal of Veterinary Microbiology. 2010; 140(1-2): 176-179.
- Barot P. Studies on pharmacokinetics of cefpirome in rats and effect of fever and co-administration of ketoprofen on pharmacokinetics of cefpirome along with its safety in goats.2011; Ph.D. Thesis. Anand Agricultural University. Gujarat, India.
- Bryskier A. New concepts in the field of cephalosporins: C-3 quaternary ammonium cephems (Group 1V). Clinical Microbiology and Infections. 1997; 3(1): 1-6.
- Donowitz GR. Third generation cephalosporin. Infect. Dis. Clin. North. Am. 1989; 3 (3): 595-612.
- Kadota T, Kondoh H, Chikazawa H, Kawano S, Kuroyanagi K, Ohta S, Ishikawa K, Takahashi N, Kohmura H and Kai S. Four week repeated dose oral toxicity study of BMY-28142 cefepime in juvenile rats. Jpn J Antobiot. 1990; 43(7): 1243-1259.
- Kadota T, Kondoh H, Chikazawa H, Kuroyanagi K, Ishikawa K, Kawano S, Sakakura K, Takahashi N, Funahashi N and Shimizu N. Cefepime (diHCl/L-arginine blend): intravenous continuous infusion and/orsingle dose subcutaneous toxicity study in rats and dogs. Jpn J Antibiot. 1992; 45(6):612-9.
- Kai S, Kohmura H, Ishikawa K, Kawano S, Sakai A, Kuroyanagi K, Kadota T and Takahashi N. Reproductive and developmental toxicity studies on cefepimedihydrochlorideadministered subcutaneously to rats during the premating, gestation and lactation periods. Jpn J Antibiot. 1992; 45(6):642-60.
- Kalman D and Barriere SL. Review of the pharmacology, pharmacokinetics, and clinical use of cephalosporins.Texas heart institute J. 1990; 13(3): 203-215.
- Limbert M, Isert D, Klesel D, Markus A, Seeger K, Seibert G and Schrinner E. Antibacterial activity in-vitro and in-vivo and pharmacokinetics of cefquinome (HR 111V), a new broad spectrum cephalosporin.Antimicrobial Agents and Chemotherapy. 1991; 35(1):14-19.
- Maden M, Tras B, Bas AL, Elmas M, Yazar E and Birdane FM. Investigation of biochemical and haematological side-effects of cefquinome in healthy dogs. Veterinary Quarterly. 2001; 23(1): 32-34.
- Patel HB, Patel NN, Patel SD, Dewda S, Patel JH, Bhavsar SK andThaker AM. Effect of Ketoprofen Co-administration and FebrileState on Pharmacokinetic of Cefepime in Goats. Asian Journal of Animal andVeterinary Advances. 2012; 7: 46-53.
- Patel PN, Bhavsar SK, Patel UD, Pandey NK and Wadhwani KN. Safety evaluation of cefepime following repeated intravenous administration in sheep. Indian Journal of Field Veterinarians.2007; 2: 24-29.
- Rana M.P. “Studies on effect of tolfenamic acid and bioenhancertrikatu on pharmacokinetics of cefquinome and safety of simultaneous administration of cefquinome and tolfenamic acid in patanwadi sheep”. 2014; M.V.Sc. Thesis. Anand Agricultural University. Gujarat, India.
- Rankin GO and Sutherland CH. Nephrotoxicity of aminoglycosides and cephalosporins in combination. Adverse Drug React Acute Poisioning Rev.1989; 8(2): 73-88.
- Teitz NW. Textbook of clinical chemistry. 1999; Publ. W.B. Saunders Co. Philadelphia, pp. 582-584.
- Tiwari S. Studies on effect of febrile condition and coadministration of meloxicam on pharmacokinetics of cefquinome and its safety in goats.2014; Ph.D. thesis (Pharmacology and toxicology), Navsari Agriculture University, Navsari.
Abstract Views: 459
PDF Views: 1