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Hepatoprotective and Antioxidant Role of Resveratrol on Bisphenol A - Induced Toxicity in Rats
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Male albino rats of Wistar strain were injected intraperitoneally with bisphenol A or/and resveratrol for 8 weeks. Serum C-reactive protein, Alpha-fetoprotein and tumor necrosis-alpha of bisphenol A-treated rats were increased significantly. Myeloperoxidase, xanthine oxidase, nitric oxide, lipid peroxidation and total oxidative status of the liver in bisphenol A - treated rats were increased significantly, which were restored to normal in resveratrol co-treated group. Endogenous antioxidant status as the activity of superoxide dismutase, catalase and glutathione peroxidase were found to be decreased significantly in the liver of the bisphenol-A treated group, which were significantly raised in resveratrol-administered groups. The non-enzymatic antioxidants as total antioxidant and thiol levels were decreased significantly as the effect of bisphenol-A that was effectively enhanced by resveratrol treatment. The liver of bisphenol-A -treated rats showed severe congestion of the hepatic tissues as well as hemorrhage was observed. The data suggested that resveratrol exerts its protective effect by modulating the extent of oxidative status and improving the enzymatic/non-enzymatic antioxidant defense system, moreover, decreases the pathological changes in animals against the liver damage caused by bisphenol-A.
Keywords
Bisphenol-A, Resveratrol, Enzymatic/Non-Enzymatic Antioxidant.
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- Elswefy S.E, Abdallah F.A, Atteia H.H, Wahba A.S. and Hasan R.A. Inflammation, oxidative stress and apoptosis cascade implications in bisphenol A-induced liver fibrosis in male rats. Int. J. Exp. Path., 2016, 97:369–379.
- Biedermann S., Tschudin P. & Grob K. (2010) Transfer of bisphenol A from thermal printer paper to the skin. Anal. Bioanal. Chem. 398, 571–576.
- Wan Y., Choi K., Kim S. et al. (2010) Hydroxylated polybrominated diphenyl ethers and bisphenol A in pregnant women and their matching fetuses: placental transfer and potential risks. Environ. Sci. Technol. 44, 5233–5239.
- Rochester J.R. (2013) Bisphenol A and human health: a review of the literature. Reprod. Toxicol. 42, 132–155
- Moon MK, Kim MJ, Jung IK, Koo YD, Ann HY, Lee KJ, et al. Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level. J Korean Med Sci 2012;27:644–52.
- Bindhumol V, Chitra KC, Mathur PP. Bisphenol A induces reactive oxygen species generation in the liver of male rats. Toxicology 2003;188:117–24.
- Kurman RJ, Scardino PT, RMcIntire K, Waldmann TA, Javadpour N. Cellular localization of alpha-fetoprotein and human chorionic gonadotropin in germ cell tumors of the testis using an indirect immunoperoxidase technique. A new approach to classification utilizing tumor markers Cancer. 1977; 40(5): 2136–51.
- Ozcan P, Fıcıcıoglu C, Yıldırıma oK, Ozkan F, Akkaya H, Aslan İ. Protective effect of resveratrol against oxidative damage to ovarian reserve in female Sprague–Dawley rats. Reproductive Bio Medicine 2015; 31 (3): 404–10.
- Lin ZS, Ku CF, Guan YF, Xiao HT, Shi XK, Wang HQ, Bian ZX, Tsang SW, Zhang HJ. Dihydro-resveratrol ameliorates lung injury in rats with cerulein-induced acute pancreatitis. Phytother Res. 2016; 30 (4): 663-670
- Hassan Z.K., Elobeid M.A., Virk P. (2012) Bisphenol A induces hepatotoxicity through oxidative stress in rat model. Oxid. Med. Cell Longev. 2012, 194829.
- Oktem G, Uysal A, Oral O, Sezer ED, Olukman M, Erol A. Resveratrol attenuatesdoxorubicin-induced cellular damage by modulating nitric oxide and apoptosis. Exp Toxicol Pathol 2012; 64: 471–9.
- Marklund S, Marklund G. 1974. Involvement of the super-oxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Europ. J. Biochem. 47: 469–474.
- Aebi H. 1984. Catalase in vitro. Meth. Enzymol. 105:121 –126.
- Hafeman D. G., Sunde R. A. and Hoekstra W. G. 1974. Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J. Nulr. 104: 580-587.
- Wilder JM, Thomson AM, Grigor KM, Howard G, Stewart GD. A unique case of an alpha-fetoprotein-producing lung cancer with testicular metastasis Can Urol Assoc J 2012; 6(5): 364–66.
- Evans MD, Dizdaroglu M, Cooke MS. Oxidative DNA damage and disease: induction, repair, and significance. Mutat Res 2004; 567: 1-61.
- Winterbourn CC, Kettle AJ. Biomarkers of myeloperoxidasederived hypochlorous acid. Free Radic Biol Med 2000; 29: 403–09.
- van Esterik JC, Dolle ME, Lamoree MH, van Leeuwen SP, Hamers T, Legler J, van der Ven LT. Programming of metabolic effects in C57BL/6JxFVB mice by exposure to bisphenol A during gestation and lactation. Toxicology. 2014 Jul 3;321:40-52.
- Dhouib H, Jallouli M, Draief M, Bouraoui S, El-Fazaa S. Oxidative damage and histopathological changes in the lung of rat chronically exposed to nicotine alone or associated with ethanol. Pathologie Biologie 2015; 63 (6): 258–67.
- Nahla S. El-Shenawy, Mohammad S. AL-Harbi, Reham Z. Hamza. Effect of vitamin E and selenium separately and in combination on biochemical, immunological and histological changes induced by sodium azide in male mice. Experimental and Toxicologic Pathology 67 (2014) 65–76.
- Juan ME, Vinardell MP, Planas JM. The daily oral administration of high doses of trans-resveratrol to rats for 28 days is not harmful. J Nutr 2002; 132(2):257-60.
- Palsamy P, Subramanian S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin–nicotinamide induced experimental diabetic rats. Biomed Pharmacother 2008; 62: 598–605.
- Reham Z. Hamza, Nahla S. El-Shenawy. Anti-inflammatory and antioxidant role of resveratrol on nicotine-induced lung changes in male rats. Toxicology Reports 4 (2017) 399–407.
- Lai X, Pei Q, Song X, Zhou X, Yin Z, Jia R, Yin L. The enhancement of immune function and activation of NF-κB by resveratrol-treatment in immunosuppressive mice. Intern Immunopharmacol 2016; 33: 42-47.
- Yazir Y, Utkan T, Gacar N, Aricioglu F. Resveratrol exerts anti-inflammatory and neuroprotective effects to prevent memory deficits in rats exposed to chronic unpredictable mild stress. Physiology behavior 2015;138: 297-304.
- Davis CW, Gonzales LW, Ballard RA, Ballard PL, Guo C, Gow AJ. Expression of nitric oxide synthases and endogenous NO metabolism in bronchopulmonary dysplasia. Pediatr. Pulmonol. 2008; 43:703-709.
- Spainer G, Xu H, Xia N, Tobias S, Deng S, Wojnowski L, et al. Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol 2009;60: 111-16.
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