Toxicology International (Formerly Indian Journal of Toxicology)

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Immunotoxic and Genotoxic Potential of Arsenic and its Chemical Species in Goats


Affiliations
  • College of Veterinary Sciences and Animal Husbandry, Department of Veterinary Pharmacology and Toxicology, Tripura, India
  • Eastern Regional Station, Indian Veterinary Research Institute, kolkata, India
  • West Bengal University of Animal and Fishery Sciences, Department of Veterinary Parasitology, Kolkata, India
  • West Bengal University of Animal and Fishery Sciences, Department of Veterinary Pharmacology and Toxicology, Kolkata, India
     

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The study investigated the immunotoxic and genotoxic effect of arsenic and its different species on goats. It was found that arsenic causes haematological crisis. Histopathological changes in spleen and reduced serum immunoglobulin G level without any changes in formazan production in arsenic‑treated animals indicated that arsenic is toxic to the humoral immune system. Increased caspase‑3 production and higher number of TUNEL (terminal deoxynucleotidyl transferase‑mediated dUTP nick‑end labelling)‑positive bone marrow cells along with oligonucleosomal DNA fragmentation on agarose gel suggested apoptosis induction by arsenic in the bone marrow cells of goat. Total arsenic concentration in the plasma, bone marrow, and spleen of the exposed group was, respectively, 1.22 ± 0.11, 2.20 ± 0.21, and 3.39 ± 0.14 ppm. Speciation study revealed that arsenite and organoarsenic were the major arsenic species in these samples, suggesting their role in immunotoxic and genotoxic potential in goats.

Keywords

Apoptosis, arsenic species, goat, immunotoxicity
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  • Immunotoxic and Genotoxic Potential of Arsenic and its Chemical Species in Goats

Abstract Views: 255  |  PDF Views: 0

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Abstract


The study investigated the immunotoxic and genotoxic effect of arsenic and its different species on goats. It was found that arsenic causes haematological crisis. Histopathological changes in spleen and reduced serum immunoglobulin G level without any changes in formazan production in arsenic‑treated animals indicated that arsenic is toxic to the humoral immune system. Increased caspase‑3 production and higher number of TUNEL (terminal deoxynucleotidyl transferase‑mediated dUTP nick‑end labelling)‑positive bone marrow cells along with oligonucleosomal DNA fragmentation on agarose gel suggested apoptosis induction by arsenic in the bone marrow cells of goat. Total arsenic concentration in the plasma, bone marrow, and spleen of the exposed group was, respectively, 1.22 ± 0.11, 2.20 ± 0.21, and 3.39 ± 0.14 ppm. Speciation study revealed that arsenite and organoarsenic were the major arsenic species in these samples, suggesting their role in immunotoxic and genotoxic potential in goats.

Keywords


Apoptosis, arsenic species, goat, immunotoxicity