Toxicology International (Formerly Indian Journal of Toxicology)

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Water Soluble Fraction of Diesel Fuel Induced Histopathological Alterations in the Liver of Channa punctatus


Affiliations
1 Department of Zoology, D.A.V. (P.G.) College, Dehradun - 248 001, Uttarakhand, India
     

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The aim of this work was to verify the effects of water soluble fraction (WSF) of diesel fuel in liver of Channa punctatus. The fishes were exposed to sublethal concentration of WSF of diesel (5%-DF1, 10%-DF2, 15%-DF3, 20%- DF4 and 25%-DF5) for 21 days. Significant histopathological lesions observed were dilation, congestion, thrombosis formation in hepatoportal blood vessel, melanomacrophage centers, hemolysis, hemorrhage, lymphocytic infiltration between the hepatocytes and necrosis & fibrosis in hepatocytes were the prominent changes in liver. The histological analysis showed increasing damages dose-dependents and time-dependents.

Keywords

Diesel fuel, fish, histopathology, liver, WSF
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  • Water Soluble Fraction of Diesel Fuel Induced Histopathological Alterations in the Liver of Channa punctatus

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Authors

Preeti Handa Kakkar
Department of Zoology, D.A.V. (P.G.) College, Dehradun - 248 001, Uttarakhand, India
R. M. Saxena
Department of Zoology, D.A.V. (P.G.) College, Dehradun - 248 001, Uttarakhand, India
N. S. Rathee
Department of Zoology, D.A.V. (P.G.) College, Dehradun - 248 001, Uttarakhand, India
Mamta Joshi
Department of Zoology, D.A.V. (P.G.) College, Dehradun - 248 001, Uttarakhand, India

Abstract


The aim of this work was to verify the effects of water soluble fraction (WSF) of diesel fuel in liver of Channa punctatus. The fishes were exposed to sublethal concentration of WSF of diesel (5%-DF1, 10%-DF2, 15%-DF3, 20%- DF4 and 25%-DF5) for 21 days. Significant histopathological lesions observed were dilation, congestion, thrombosis formation in hepatoportal blood vessel, melanomacrophage centers, hemolysis, hemorrhage, lymphocytic infiltration between the hepatocytes and necrosis & fibrosis in hepatocytes were the prominent changes in liver. The histological analysis showed increasing damages dose-dependents and time-dependents.

Keywords


Diesel fuel, fish, histopathology, liver, WSF