Toxicology International (Formerly Indian Journal of Toxicology)

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Toxicity studies on a Unani herbal formulation “Capsule Hudar” in albino rats


Affiliations
1 Regional Research Institute of Unani Medicine, University of Kashmir Campus, Srinagar 190 006 JK, India
2 Department of Biochemistry, University of Kashmir Campus, Srinagar 190 006 JK, India
3 Central Council for Research in Unani Medicine, New Delhi, India
     

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Capsule Hudar, a very effective compound formulation of Unani System of Medicine, contains Azraqi (Strychnos nux vomica) a deadly poison as one of its constituents. However, it (Strychnos nux vomica) is detoxified, using a classical crude method, before its use to prepare the drug. Results on the evaluation of the drug at dose rate of 5 mg/kg body weight, orally as aqueous extract for 60 days in either sex for its toxicity in Wistar albino rats (150 ± 10g body weight) did not show any significant change in the blood glucose, blood urea and blood urea nitrogen and serum albumin and proteins levels. The activities of GOT/GPT and ACP/ALP levels in serum, brain, kidney, liver and spleen were also not significantly different when compared to controls.

Keywords

capsule hudar, detoxification, strychnine,strychnos nux vomica, Unani herbal formulation
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  • Toxicity studies on a Unani herbal formulation “Capsule Hudar” in albino rats

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Authors

Seema Akbar
Regional Research Institute of Unani Medicine, University of Kashmir Campus, Srinagar 190 006 JK, India
A. Masood
Department of Biochemistry, University of Kashmir Campus, Srinagar 190 006 JK, India
Shamshad A. Khan
Central Council for Research in Unani Medicine, New Delhi, India
Showkat Ali
Regional Research Institute of Unani Medicine, University of Kashmir Campus, Srinagar 190 006 JK, India

Abstract


Capsule Hudar, a very effective compound formulation of Unani System of Medicine, contains Azraqi (Strychnos nux vomica) a deadly poison as one of its constituents. However, it (Strychnos nux vomica) is detoxified, using a classical crude method, before its use to prepare the drug. Results on the evaluation of the drug at dose rate of 5 mg/kg body weight, orally as aqueous extract for 60 days in either sex for its toxicity in Wistar albino rats (150 ± 10g body weight) did not show any significant change in the blood glucose, blood urea and blood urea nitrogen and serum albumin and proteins levels. The activities of GOT/GPT and ACP/ALP levels in serum, brain, kidney, liver and spleen were also not significantly different when compared to controls.

Keywords


capsule hudar, detoxification, strychnine,strychnos nux vomica, Unani herbal formulation