Toxic effects of sub-chronic oral exposure of indoxacarb on biochemical parameters in buffalo calves

Repeated oral administration of Indoxacarb, an oxadiazine insecticide, at the dose rate of 1 mg/kg/day for 90 consecutive days produced mild signs of toxicity in buffalo calves. Indoxacarb significantly elevated the plasma levels of aspartate aminotransferase (38.3%), alanine aminotransferase (52.9%), alkaline phosphatase (29.5%) and acid phosphatase (36.6%). Cholinesterase levels in plasma, whole blood and erythrocyte also showed elevation. Indoxacarb did not produce any significant alterations in levels of blood urea nitrogen and creatinine. However there was an increase in blood glucose (16.9%), plasma cholesterol (19.6%) and total plasma proteins (10.8%). It can be concluded from the present study that indoxacarb is a low risk insecticide in buffalo calves.