Toxicology International (Formerly Indian Journal of Toxicology)

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An Acute Toxicity Study of Tylophora Indica Leaves Extract in Wistar Rats


Affiliations
1 Department of Veterinary Pathology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India
2 Department of Veterinary Pathology, Maharashtra Animal and Fishery Sciences University, MAFSU, Nagpur – 440006, Maharashtra, India
3 Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, India
4 Department of Veterinary Public Health, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India
5 Department of Veterinary Pharmacology and Toxicology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India
6 Hospital Registrar, TVCC Complex, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India
     

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The present investigation was carried out to evaluate the safety of hydroalcoholic extract of Tylophora indica leaves after single dose administration to determine its potential toxicity individually as per Organisation for Economic Co-operation and Development [OECD] 423 guideline. General behaviour, adverse effects and mortality parameters were studied for up to 14 days. Extract was found safe at the oral doses of 2000 mg/kg b. wt. There were no apparent toxicity signs and death observed during experimental trial. Gross necropsy examination revealed no abnormal lesions. In view of the dose of Tylophora indica leaves consumed in traditional medicine, it is observed that there is a wide margin of safety for the therapeutic use.

Keywords

Acute Toxicity, OECD Guideline 423, Tylophora Indica, Wistar Rats.
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  • An Acute Toxicity Study of Tylophora Indica Leaves Extract in Wistar Rats

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Authors

N. S. Bembde
Department of Veterinary Pathology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India
P. V. Meshram
Department of Veterinary Pathology, Maharashtra Animal and Fishery Sciences University, MAFSU, Nagpur – 440006, Maharashtra, India
P. D. Gadhave
Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, Punjab – 144411, India
V. M. Vaidya
Department of Veterinary Public Health, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India
S. S. Sole
Department of Veterinary Pharmacology and Toxicology, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India
R. R. Rohi
Hospital Registrar, TVCC Complex, Mumbai Veterinary College, Mumbai – 400012, Maharashtra, India

Abstract


The present investigation was carried out to evaluate the safety of hydroalcoholic extract of Tylophora indica leaves after single dose administration to determine its potential toxicity individually as per Organisation for Economic Co-operation and Development [OECD] 423 guideline. General behaviour, adverse effects and mortality parameters were studied for up to 14 days. Extract was found safe at the oral doses of 2000 mg/kg b. wt. There were no apparent toxicity signs and death observed during experimental trial. Gross necropsy examination revealed no abnormal lesions. In view of the dose of Tylophora indica leaves consumed in traditional medicine, it is observed that there is a wide margin of safety for the therapeutic use.

Keywords


Acute Toxicity, OECD Guideline 423, Tylophora Indica, Wistar Rats.

References





DOI: https://doi.org/10.18311/ti%2F2018%2Fv25i3%2F23751