Toxicology International (Formerly Indian Journal of Toxicology)

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Modulation of Oxidative Stress Mediators in Adjuvant Induced Arthritis by Herbal Adaptogen Boswellia serrata


Affiliations
1 JRF, ICAR-NDRI, Southern Regional Station, Adugodi, Bengaluru – 560030, Karnataka, India
2 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
3 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Kanchikacherla - 505326, Telangana, India
     

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A study was carried out to evaluate Boswellia serrata on adjuvant induced oxidative stress in rats. Intradermal administration of Freund’s adjuvant to induce rheumatoid arthritis consequently produced oxidative damage as indicated by an increase in thiobarbituric acid reducing substances, myeloperoxidase, protein carbonyls and a reduction in superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in tissue homogenates. Oral administration of methanolic extracts ofBoswellia serrata at 500 mg/kg body weight re-established the antioxidant profile. Co-treatment with an anti-inflammatory agent, meloxicam showed an enhanced healing effect. Hence, a significant restorative effect was witnessed with the herbal adaptogen Boswellia serrata.

Keywords

Adjuvant Arthritis, Antioxidants, Boswellia serrata, Oxidative Stress.
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  • Modulation of Oxidative Stress Mediators in Adjuvant Induced Arthritis by Herbal Adaptogen Boswellia serrata

Abstract Views: 270  |  PDF Views: 1

Authors

R. Divisha
JRF, ICAR-NDRI, Southern Regional Station, Adugodi, Bengaluru – 560030, Karnataka, India
M. Usha Rani
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
B. Kala Kumar
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad – 500030, Telangana, India
A. Gopala Reddy
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Korutla, Kanchikacherla - 505326, Telangana, India

Abstract


A study was carried out to evaluate Boswellia serrata on adjuvant induced oxidative stress in rats. Intradermal administration of Freund’s adjuvant to induce rheumatoid arthritis consequently produced oxidative damage as indicated by an increase in thiobarbituric acid reducing substances, myeloperoxidase, protein carbonyls and a reduction in superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione in tissue homogenates. Oral administration of methanolic extracts ofBoswellia serrata at 500 mg/kg body weight re-established the antioxidant profile. Co-treatment with an anti-inflammatory agent, meloxicam showed an enhanced healing effect. Hence, a significant restorative effect was witnessed with the herbal adaptogen Boswellia serrata.

Keywords


Adjuvant Arthritis, Antioxidants, Boswellia serrata, Oxidative Stress.

References





DOI: https://doi.org/10.18311/ti%2F2018%2Fv25i4%2F23085