Toxicology International (Formerly Indian Journal of Toxicology)

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90-days Repeated Oral Dose Toxicity Study on Jawarish Bisbasa (A Polyherbal Unani Formulation)


Affiliations
1 Department of Pharmacology, Central Research Institute of Unani Medicine, Hyderabad - 500038, Telangana, India
2 Central Council for Research in Unani Medicine, New Delhi - 110058, India
     

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Jawarish Bisbasa (JBS) is a polyherbal Unani formulation clinically indicated for the treatment of Zof-e-Meda (Stomach Weakness), Zof-e-Hazm (Dyspepsia), Bawaseer Amya (Blind piles), Nafkh-e-Shikam (Flatulence) and Ghasiyan (Nausea). The present study was designed to investigate toxicity of JBS following 90 days repeated oral administration in rats. JBS was orally administered at the dose levels of 1000 and 2000 mg/kg bw/day. The results obtained showed that oral administration of JBS at doses 1000 and 2000 mg/kg bw did not show any significant adverse effects on survival, body weight gain, hematology, clinical biochemistry, gross necropsy and histopathology. Therefore, No-Observed-Adverse-Effect-Level (NOAEL) is found to be greater than 2000 mg/kg body weight.

Keywords

Jawarish Bisbasa, Polyherbal, Toxicity, Unani.
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  • 90-days Repeated Oral Dose Toxicity Study on Jawarish Bisbasa (A Polyherbal Unani Formulation)

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Authors

Mohd Urooj
Department of Pharmacology, Central Research Institute of Unani Medicine, Hyderabad - 500038, Telangana, India
Muskula Anudeep Reddy
Department of Pharmacology, Central Research Institute of Unani Medicine, Hyderabad - 500038, Telangana, India
Mahe Alam
Central Council for Research in Unani Medicine, New Delhi - 110058, India
Munawwar Husain Kazmi
Department of Pharmacology, Central Research Institute of Unani Medicine, Hyderabad - 500038, Telangana, India
Gulam Mohammed Husain
Department of Pharmacology, Central Research Institute of Unani Medicine, Hyderabad - 500038, Telangana, India

Abstract


Jawarish Bisbasa (JBS) is a polyherbal Unani formulation clinically indicated for the treatment of Zof-e-Meda (Stomach Weakness), Zof-e-Hazm (Dyspepsia), Bawaseer Amya (Blind piles), Nafkh-e-Shikam (Flatulence) and Ghasiyan (Nausea). The present study was designed to investigate toxicity of JBS following 90 days repeated oral administration in rats. JBS was orally administered at the dose levels of 1000 and 2000 mg/kg bw/day. The results obtained showed that oral administration of JBS at doses 1000 and 2000 mg/kg bw did not show any significant adverse effects on survival, body weight gain, hematology, clinical biochemistry, gross necropsy and histopathology. Therefore, No-Observed-Adverse-Effect-Level (NOAEL) is found to be greater than 2000 mg/kg body weight.

Keywords


Jawarish Bisbasa, Polyherbal, Toxicity, Unani.

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DOI: https://doi.org/10.18311/ti%2F2018%2Fv25i4%2F23868