Toxicology International (Formerly Indian Journal of Toxicology)

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Aqueous Extract of Ficus Vogelii Potentiates Changes in Liver Function and Hematological Parameters of Aspirin Treated Rats


Affiliations
1 Department of Physiology, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria
2 Department of Anatomy, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria
     

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Objective: This study was carried out to investigate the possible effect of Ficus vogelii (FV) on liver function and some he matological parameters of male Wistar rats administered with aspirin. Materials and Methods: The animals were divided into 4 groups comprisingx 5 animals each. Group 1: Normal control group, Group 2: Positive control group which received 500 mg/kg of aspirin for three days. Group 3: Pre-treated with aqueous extract of Ficus vogelii (600 mg/kg body weight-bwt) for 14 days and then administered with Aspirin (500 mg/kg bwt) for 3 days. Group 4: received 500mg/kg of aspirin for three days, and then treated with aqueous extract of FV (600 mg/kg bwt) for 14 days. Results: There was a significant decrease (p<0.05) in PCV in the treatment groups 2, 3 and 4 (39.00±5.19, 41.50±2.59 and 41.50±1.91% respectively) when compared to the control group (62.50±1.44%). A significant decrease was recorded in WBC and platelet count in group 3 (pre-treatment) and 4 (treatment groups) (9.6±0.40×10/L and 8.8±1.10 × 10/L respectively) when compared to group 2. A significant decrease was also observed in AST, ALT and ALP levels in FV treated group 4 (9.50±0.29 and 138.50±3.75 μ/L respectively) when compared to group 2 (aspirin-treated group: 27.50±0.87 and 194.50±12.41 μ/L respectively). Conclusion: This extract may thus be useful in ameliorating Aspirin induced liver damage.

Keywords

Aspirin, Ficus vogelii, Hematological, Liver Function.
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  • Aqueous Extract of Ficus Vogelii Potentiates Changes in Liver Function and Hematological Parameters of Aspirin Treated Rats

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Authors

O. Ekakitie Ofovwe
Department of Physiology, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria
G. Konyefom Nwaeze
Department of Physiology, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria
O. Azubuike-Osu Sharon
Department of Physiology, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria
O. George Itoro
Department of Anatomy, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria
K. Nwite Nnanna
Department of Anatomy, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria
C. Uzomba Godwin
Department of Anatomy, Alex Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki, Nigeria

Abstract


Objective: This study was carried out to investigate the possible effect of Ficus vogelii (FV) on liver function and some he matological parameters of male Wistar rats administered with aspirin. Materials and Methods: The animals were divided into 4 groups comprisingx 5 animals each. Group 1: Normal control group, Group 2: Positive control group which received 500 mg/kg of aspirin for three days. Group 3: Pre-treated with aqueous extract of Ficus vogelii (600 mg/kg body weight-bwt) for 14 days and then administered with Aspirin (500 mg/kg bwt) for 3 days. Group 4: received 500mg/kg of aspirin for three days, and then treated with aqueous extract of FV (600 mg/kg bwt) for 14 days. Results: There was a significant decrease (p<0.05) in PCV in the treatment groups 2, 3 and 4 (39.00±5.19, 41.50±2.59 and 41.50±1.91% respectively) when compared to the control group (62.50±1.44%). A significant decrease was recorded in WBC and platelet count in group 3 (pre-treatment) and 4 (treatment groups) (9.6±0.40×10/L and 8.8±1.10 × 10/L respectively) when compared to group 2. A significant decrease was also observed in AST, ALT and ALP levels in FV treated group 4 (9.50±0.29 and 138.50±3.75 μ/L respectively) when compared to group 2 (aspirin-treated group: 27.50±0.87 and 194.50±12.41 μ/L respectively). Conclusion: This extract may thus be useful in ameliorating Aspirin induced liver damage.

Keywords


Aspirin, Ficus vogelii, Hematological, Liver Function.

References





DOI: https://doi.org/10.18311/ti%2F2019%2Fv26i3%264%2F23857