Toxicology International (Formerly Indian Journal of Toxicology)

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In Silico Studies and Histopathological Analysis on the Bioremediation Effect of Spirulina in Various Tissues of Diclofenac Treated Pangasius Sps


Affiliations
1 Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, India
     

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The aquatic biome is an integral part of Earth’s survival. Humans, with an attitude to lead a comfortable life, have invaded the ecosystem to a larger extent owing to many direct and indirect catastrophes in the longer run. Our aim was to establish the link between the genes and compounds that turn toxic to the organisms over due course of time. With the selected compound as diclofenac, Comparative Toxicogenomics database was used to identify the diseases related to the compounds, the top expressing genes, and the common genes of the compounds. By incorporating the coalescence of spirulina bioremediation under histopathological studies, the effect of the algae was observed. From these two studies, we were able to conclude that there was a significant link between the effects of the compound on the organisms.

Keywords

Diseases, Remediation, Spirulina, Toxicity
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  • In Silico Studies and Histopathological Analysis on the Bioremediation Effect of Spirulina in Various Tissues of Diclofenac Treated Pangasius Sps

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Authors

K. S. Shreenidhi
Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, India
Saranya Sri Santhanam
Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, India
Shreaya Bhaskar
Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, India
Sowmia Narayan Sridhar
Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, India
B. Vijaya Geetha
Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai – 602105, Tamil Nadu, India

Abstract


The aquatic biome is an integral part of Earth’s survival. Humans, with an attitude to lead a comfortable life, have invaded the ecosystem to a larger extent owing to many direct and indirect catastrophes in the longer run. Our aim was to establish the link between the genes and compounds that turn toxic to the organisms over due course of time. With the selected compound as diclofenac, Comparative Toxicogenomics database was used to identify the diseases related to the compounds, the top expressing genes, and the common genes of the compounds. By incorporating the coalescence of spirulina bioremediation under histopathological studies, the effect of the algae was observed. From these two studies, we were able to conclude that there was a significant link between the effects of the compound on the organisms.

Keywords


Diseases, Remediation, Spirulina, Toxicity

References





DOI: https://doi.org/10.18311/ti%2F2021%2Fv28i3%2F27327