Toxicology International (Formerly Indian Journal of Toxicology)

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Multidisciplinary Approach to the Management of Aluminium Phosphide Poisoning – Experience From A Tertiary Care Hospital


Affiliations
1 Department of Cardiology, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai – 400012, Maharashtra, India
2 Department of Pharmacology, Vedanta Institute of Medical Sciences, Dahanu – 401606, Maharashtra, India
3 Department of Forensic Medicine, H. B. T. Medical College and Cooper Hospital, Mumbai – 400056, Maharashtra, India
     

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A usual ingredient of rodenticide, aluminium phosphide is known for its poisoning which happens to be one of the common causes of suicides in India. Signs and symptoms of toxicity with aluminium phosphide are wellknown. Circulatory failure plays an important role in mortality with aluminium phosphide poisoning. Aluminium phosphide poisoning is associated with high mortality as there is no specific antidote available yet. There is a need for correct treatment approach to manage this fatal poisoning. In this retrospective analysis we present a data of forty cases registered at a tertiary care hospital in Mumbai. We developed a multidisciplinary treatment approach to aluminium phosphide poisoning which may help in better patient outcomes. Correct treatment protocol with supportive therapy resulted in better survival in these patients. Hence we propose this aggressive, appropriate management with continuous haemodynamic monitoring and multidisciplinary treatment approach to reduce the mortality in aluminium phosphide poisoning.

Keywords

Aluminium Phosphide Toxicity, Multidisciplinary Treatment, Rodenticide Poisoning
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  • Multidisciplinary Approach to the Management of Aluminium Phosphide Poisoning – Experience From A Tertiary Care Hospital

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Authors

Dheeraj B. More
Department of Cardiology, Seth G. S. Medical College and K. E. M. Hospital, Parel, Mumbai – 400012, Maharashtra, India
Harshad Malve
Department of Pharmacology, Vedanta Institute of Medical Sciences, Dahanu – 401606, Maharashtra, India
Mahendra N. Wankhede
Department of Forensic Medicine, H. B. T. Medical College and Cooper Hospital, Mumbai – 400056, Maharashtra, India

Abstract


A usual ingredient of rodenticide, aluminium phosphide is known for its poisoning which happens to be one of the common causes of suicides in India. Signs and symptoms of toxicity with aluminium phosphide are wellknown. Circulatory failure plays an important role in mortality with aluminium phosphide poisoning. Aluminium phosphide poisoning is associated with high mortality as there is no specific antidote available yet. There is a need for correct treatment approach to manage this fatal poisoning. In this retrospective analysis we present a data of forty cases registered at a tertiary care hospital in Mumbai. We developed a multidisciplinary treatment approach to aluminium phosphide poisoning which may help in better patient outcomes. Correct treatment protocol with supportive therapy resulted in better survival in these patients. Hence we propose this aggressive, appropriate management with continuous haemodynamic monitoring and multidisciplinary treatment approach to reduce the mortality in aluminium phosphide poisoning.

Keywords


Aluminium Phosphide Toxicity, Multidisciplinary Treatment, Rodenticide Poisoning

References