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A Review On The Adaptogenic Activity Of Potent Rasayana Tinospora Cordifolia


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1 Department Of Pharmacology, Srmist, Kattankulatthur, Chengalpattu - 603203, Tamil Nadu, India
     

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Tinospora cordifolia is an herbaceous vine that belongs to the Menispermaceae family, a succulent woody shrub genus, native to the tropical Indian sub-continent, and it is known for its common names: “Guduchi”, “giloy”, “amrita”, “gurjo”, and “heart-leaved moonseed”. The recent recognition and biological role of active components in disease management in the plant have contributed to an active interest in the plant worldwide. Extracts of T. cordifolia are widely used as anti-spasmodic, anti-microbial, antiperiodic, immunomodulatory, anti-inflammatory, anti-arthritic, anti-allergic, endocrine disorders like anti-diabetic, hypolipidaemic, etc. in various herbal formulations to treat different diseases. It helps reduce the resistance to insulin and stress, revitalises all the tissues of the body, and spontaneously promotes metabolism. However, this adaptogenic ability is also under-explored. Stress and ageing disorders need to be treated independently. The current review paper mainly focused on stress, depression, and the anti-stress properties (adaptogen) of T. cordifolia. Depression and stress, along with disrupted metabolic and reproductive properties, are high-risk factors in polycystic ovarian syndrome patients. Further studies are needed to focus on adaptogenic activity to relieve certain endocrine disorders that occur due to stress, often ovarian cysts, female menstrual irregularities, and hormonal imbalance.

Keywords

Adaptogenic Property, Polycystic Ovarian Syndrome, Stress, Tinospora Cordifolia.
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  • Ghosh S, Saha S. Tinospora cordifolia: One plant, many roles. Anc Sci Life. 2012; 31(4):151. https://doi.org/10.4103/0257- 7941.107344. PMid:23661861. PMCid:PMC3644751.
  • Tsigos C, Kyrou I, Kassi E, Chrousos GP. Stress, endocrine physiology and pathophysiology. Endotext. 2000; 17.
  • Panossian AG, Efferth T, Shikov AN, Pozharitskaya ON, Kuchta K, Mukherjee PK, et al. Evolution of the adapto genic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases. Med Res Rev. 2021; 41(1):630-703. https://doi.org/10.1002/ med.21743. PMid:33103257. PMCid:PMC7756641.
  • Rider C V, Morata T, Selgrade MJK, Sexton K. Consideration of physical stressors in cumulative risk assessment. Chem Mix Comb Chem Nonchemical Stress Expo Toxicity, Anal Risk Cham. 2018:467-492. https://doi.org/10.1007/978-3 319-56234-6_16.
  • Kogler L, Müller VI, Chang A, Eickhoff SB, Fox PT, Gur RC, Derntl B. Psychosocial versus physiological stress - Meta analyses on deactivations and activations of the neural correlates of stress reactions. Neuroimage. 2015; 119:235- 251. https://doi.org/10.1016/j.neuroimage.2015.06.059. PMid:26123376. PMCid:PMC4564342.
  • Aziz NSB, Saidon R, Manan SKA, Sueb R. Psycho-spiritual treatment: An exploratory study on its practices. J Crit Rev. 2020; 7(8):1007-1011.
  • Olff M. Stress, depression and immunity: The role of defense and coping styles. Psychiatry Res. 1999; 85(1):7-15. https://doi.org/10.1016/S0165-1781(98)00139-5.
  • Ader R, Cohen N, Felten D. Psychoneuroimmunology: Interactions between the nervous system and the immune system. Lancet. 1995; 345(8942):99-103. https://doi. org/10.1016/S0140-6736(95)900667.
  • Gold PW, Machado-Vieira R, Pavlatou MG. Clinical and biochemical manifestations of depression: Relation to the neurobiology of stress. Neural Plast. 2015; 2015. https://doi.org/10.1155/2015/581976. PMid:25878903. PMCid:PMC4387963.
  • Weik U, Herforth A, Kolb-Bachofen V, Deinzer R. Acute stress induces proinflammatory signaling at chronic inflammation sites. Psychosom Med. 2008; 70(8):906-912. https:// doi.org/10.1097/PSY.0b013e3181835bf3. PMid:18799429.
  • Maes M, Song C, Lin A, De Jongh R, Van Gastel A, Kenis G, et al. The effects of psychological stress on humans: Increased production of pro-inflammatory cytokines and a Th1-like response in stress-induced anxiety. Cytokine. 1998; 10(4):313-318. https://doi.org/10.1006/cyto.1997.0290. PMid:9617578.
  • Brydon L, Edwards S, Mohamed-Ali V, Steptoe A. Socioeconomic status and stress-induced increases in interleukin-6. Brain Behav Immun. 2004; 18(3):281-290. https:// doi.org/10.1016/j.bbi.2003.09.011. PMid:15050655.
  • Ranabir S, Reetu K. Stress and hormones. Indian J Endocrinol Metab. 2011; 15(1):18. https://doi.org/10.4103/2230- 8210.77573. PMid:21584161. PMCid:PMC3079864.
  • Cameron JL. Reproductive dysfunction in primates, behaviorally induced. Encycl Stress. 2007:380-385. https://doi. org/10.1016/B978-012373947-6.00331-7.
  • Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, et al. Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol. 2003; 24(3):151-180. https://doi. org/10.1016/j.yfrne.2003.07.001. PMid:14596810.
  • Black PH. Central nervous system-immune system inter actions: Psychoneuroendocrinology of stress and its immune consequences. Antimicrob Agents Chemother. 1994; 38(1):1-6. https://doi.org/10.1128/AAC.38.1.1. PMid:8141561. PMCid:PMC284388.
  • Acevedo-Rodriguez A, Kauffman AS, Cherrington BD, Borges CS, Roepke TA, Laconi M. Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling. J Neuroendocrinol. 2018; 30(10). https://doi.org/10.1111/jne.12590. PMid:29524268. PMCid:PMC6129417.
  • Lachelin GCL, Yen SSC. Hypothalamic chronic anovulation. Obstet Gynecol Surv. 1978; 33(8):553-555. https://doi. org/10.1097/00006254-197808000-00020.
  • Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six Rasayana herbs used in ayurvedic medicine. Phyther Res. 1999; 13(4):275-291. https://doi. org/10.1002/(SICI)1099-1573(199906)13:4<275::AID PTR510>3.0.CO;2-S.
  • Bafna PA, Balaraman R. Anti-ulcer and antioxidant activity of Normacid, a herbomineral formulation. Indian J Exp Biol. 2004; 42(7):674-680.
  • Chintalwar G, Jain A, Sipahimalani A, Banerji A, Sumariwalla P, Ramakrishnan R, et al. An immu nologically active arabinogalactan from Tinospora cordifolia. Phytochemistry. 1999; 52(6):1089-1093. https:// doi.org/10.1016/S0031-9422(99)00386-6.
  • Sreemantula S, Nammi S, Kolanukonda R, Koppula S, Boini KM. Adaptogenic and nootropic activities of aqueous extract of Vitis vinifera (grape seed): An experimental study in rat model. BMC Complement Altern Med. 2005; 5(1):1- 8. https://doi.org/10.1186/1472-6882-5-1. PMid:15656916. PMCid:PMC547917.
  • Solomon GF, Amkraut AA, Rubin RT. Stress, hormones, neuroregulation and immunity. Stress Psychol Physiol Interact. 1985:99-128.
  • Rawal AK, Muddeshwar MG, Biswas SK. Rubia cordi folia, Fagonia cretica linn and Tinospora cordifolia exert neuroprotection by modulating the antioxidant system in rat hippocampal slices subjected to oxygen-glucose deprivation. BMC Complement Altern Med. 2004; 4(1):1-9. https://doi.org/10.1186/1472-6882-4-11. PMid:15310392. PMCid:PMC514713.
  • Malyshev IY, Manukhina EB. Stress, adaptation, and nitric oxide. Biochemistry (Mosc). 1998; 63(7):840-53.
  • Brown RI. Quality of life and, rehabilitation: An introduction. Quality of Life for Handicapped People. Lippincott Williams & Wilkins; 2021. https://doi. org/10.4324/9781003127338.
  • Panossian AG. Adaptogens: Tonic Herbs for Fatigue and Stress. Altern Complement Ther. 2003; 9(6):327-331. https://doi.org/10.1089/107628003322658610.
  • Brekhman II, Dardymov I V. New substances of plant origin which increase nonspecific resistance. Annu Rev Pharmacol. 1969; 9(1):419-430. https://doi.org/10.1146/ annurev.pa.09.040169.002223. PMid:4892434.
  • Padma P, Khosa RL. Anti-stress agents from natural origin. J Nat Remedies. 2002; 2(1):21-27.
  • Singh N, Nath R, Mishra N, Kohli RP. An experimental evaluation of anti-stress effects of “geriforte” (an ayurvedic drug). Pharm Biol. 1978; 16(3):125-136. https://doi. org/10.3109/13880207809083261.
  • Singh N, Nath R, Lata A, Singh SP, Kohli RP, Bhargava KP. Withania somnifera (ashwagandha), a rejuvenating herbal drug which enhances survival during stress (an adaptogen). Pharm Biol. 1982; 20(1):29-35. https://doi. org/10.3109/13880208209083282.
  • Sarma DNK, Khosa RL, Chansauria JPN, Ray AK. Effect of Tinospora cordifolia on brain neurotransmitters in stressed rats. Fitoterapia. 1995; 66(5):421-422.
  • Ghosal S, Lal J, Singh SK, Dasgupta G, Bhaduri J, Mukhopadhyay M, Bhattacharya SK. Mast cell protecting effects of shilajit and its constituents. Phyther Res. 1989; 3(6):249-252. https://doi.org/10.1002/ptr.2650030606.
  • Biswas P, Saha A, Maity LN. Antistress Activity of Tinospora cordifolia with Application of Yoga. Int J Ayurvedic Med. 2015; 6(3):220-4. https://doi.org/10.47552/ijam.v6i3.630.
  • Dunaif A. Polycystic ovary syndrome. Polycystic ovary syn drome. Health News. 1998; 4(9):4.
  • Basu B, Chowdhury O, Saha S. Possible link between stress related factors and altered body composition in women with polycystic ovarian syndrome. J Hum Reprod Sci. 2018; 11(1):10-18. https://doi.org/10.4103/jhrs.JHRS_78_17. PMid:29681710. PMCid:PMC5892097.
  • Pasquali R, Gambineri A. Cortisol and the polycystic ovary syndrome. Expert Rev Endocrinol Metab. 2012; 7(5):555- 566. https://doi.org/10.1586/eem.12.42. PMid:30780898.
  • Li L, Li X, Zhou W, Messina JL. Acute psychological stress results in the rapid development of insulin resistance. J Endocrinol. 2013; 217(2):175-184. https://doi.org/10.1530/ JOE-12-0559. PMid:23444388. PMCid:PMC3804337.
  • Lillioja S, Mott DM, Howard B V., Bennett PH, Yki Jarvinen H, Freymond D, et al. Impaired Glucose Tolerance as a Disorder of Insulin Action. N Engl J Med. 1988; 318(19):1217-1225. https://doi.org/10.1056/ NEJM198805123181901. PMid:3283552.
  • Zhao WQ, Alkon DL. Role of insulin and insulin receptor in learning and memory. Mol Cell Endocrinol. 2001; 177(1-2):125-134. https://doi.org/10.1016/S0303- 7207(01)00455-5.
  • Zhao WQ, Chen H, Quon MJ, Alkon DL. Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol. 2004; 490(1-3):71-81. https:// doi.org/10.1016/j.ejphar.2004.02.045. PMid:15094074.
  • Lewis DA, Kathol RG, Sherman BM, Winokur G, Schlesser MA. Differentiation of depressive subtypes by insulin insensitivity in the recovered phase. Arch Gen Psychiatry. 1983; 40(2):167-170. https://doi.org/10.1001/arch psyc.1983.01790020061005. PMid:6337579.
  • Winokur A, Maislin G, Phillips JL, Amsterdam JD. Insulin resistance after oral glucose tolerance testing in patients with major depression. Am J Psychiatry. 1988; 145(3):325- 330. https://doi.org/10.1176/ajp.145.3.325. PMid:2894176.
  • Yekta Z, Pourali R, Yavarian R. Behavioural and clinical factors associated with depression among individuals with diabetes. East Mediterr Heal J. 2010; 16(3):286-291. https:// doi.org/10.26719/2010.16.3.286. PMid:20795442.
  • Chen YC, Shen YC, Hung YJ, Chao-Ha C, Yeh C Bin, Perng CH. Comparisons of glucose-insulin homeostasis follow ing maprotiline and fluoxetine treatment in depressed males. J Affect Disord. 2007; 103(1-3):257-261. https://doi. org/10.1016/j.jad.2007.01.023. PMid:17320192.
  • Sullivan MD, O’Connor P, Feeney P, Hire D, Simmons DL, Raisch DW, et al. Depression predicts all-cause mortality: Epidemiological evaluation from the ACCORD HRQL substudy. Diabetes Care. 2012; 35(8):1708-1715. https://doi.org/10.2337/dc11-1791. PMid:22619083. PMCid:PMC3402260.
  • Sirmans SM, Pate KA. Epidemiology, diagnosis, and management of polycystic ovary syndrome. Clin Epidemiol. 2013; 6(1):1-13. https://doi.org/10.2147/CLEP.S37559. PMid:24379699. PMCid:PMC3872139.
  • Sharma V, Pandey D. Protective role of Tinospora cordifolia against lead-induced hepatotoxicity. Toxicol Int. 2010; 17(1):12-17. https://doi.org/10.4103/0971-6580.68343. PMid:21042467. PMCid:PMC2964743.
  • Gupta R, Sharma V. Ameliorative effects of Tinospora cordifolia root extract on histopathological and biochemical changes induced by Aflatoxin-B 1 in mice kidney. Toxicol Int. 2011; 18(2):94-98. https://doi.org/10.4103/0971- 6580.84259. PMid:21976812. PMCid:PMC3183631.
  • Patel MG, Prajapati PD. Concept of polycystic ovarian syn drome: perspectives of ayurveda and modern science. Int J Pharmacogn Phytochem Res. 2017; 9(10):1363-72. https:// doi.org/10.25258/phyto.v9i10.10462.
  • Siriwardene SD, Karunathilaka LP, Kodituwakku N, Karunarathne YAU. Clinical efficacy of Ayurveda treatment regimen on Subfertility with poly cystic ovarian syndrome (PCOS). AYU. 2010; 31(1):24. https://doi.org/10.4103/0974- 8520.68203. PMid:22131680. PMCid:PMC3215317.
  • Sharma A, Kalotra S, Bajaj P, Singh H, Kaur G. Butanol Extract of Tinospora cordifolia ameliorates cognitive deficits associated with glutamate-induced excitotoxicity: A mech anistic study using hippocampal neurons. Neuro Molecular Med. 2020; 22(1):81-99. https://doi.org/10.1007/s12017- 019-08566-2. PMid:31606849.
  • Walia V. Review: Tinospora cordifolia in the Treatment of Depression. Pharmatutor. 2015; 3(12):32-34.
  • Munshi RP, Joshi SG, Rane BN. Development of an experimental diet model in rats to study hyperlipidemia and insulin resistance, markers for coronary heart dis ease. Indian J Pharmacol. 2014; 46(3):270-276. https:// doi.org/10.4103/0253-7613.132156. PMid:24987172. PMCid:PMC4071702.
  • Prakash R, Sandhya E, Ramya N, Dhivya R, Priyadarshini M SPB. Neuroprotective activity of Ethanolic Extract of Tinospora cordifolia on LPS induced Neuroinflammation. Transl Biomed. 2017; 08(04). https://doi.org/10.21767/2172- 0479.100135.
  • Jeyachandran R, Xavier TF, Anand SP. Antibacterial activity of stem extracts of Tinospora cordifolia (willd) Hook. F & Thomson. Anc Sci Life. 2003; 23(1):40-3.
  • Patel MB, Mishra S. Isoquinoline alkaloids from Tinospora cordifolia inhibit rat lens aldose reductase. Phyther Res. 2012; 26(9):1342-1347. https://doi.org/10.1002/ptr.3721. PMid:22294283.
  • Devi MS, Muralidharan PM, Hari R, Lavanya M, Abiraamavalli TA. PCOS modulatory activity of Tinospora cordifolia leaves - An Insilico approach. Biomed Pharmacol J. 2021; 14(3):1125-1131. https://doi.org/10.13005/bpj/2215.

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  • A Review On The Adaptogenic Activity Of Potent Rasayana Tinospora Cordifolia

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Authors

Murali Krishna Moka
Department Of Pharmacology, Srmist, Kattankulatthur, Chengalpattu - 603203, Tamil Nadu, India
M. Sumithra
Department Of Pharmacology, Srmist, Kattankulatthur, Chengalpattu - 603203, Tamil Nadu, India

Abstract


Tinospora cordifolia is an herbaceous vine that belongs to the Menispermaceae family, a succulent woody shrub genus, native to the tropical Indian sub-continent, and it is known for its common names: “Guduchi”, “giloy”, “amrita”, “gurjo”, and “heart-leaved moonseed”. The recent recognition and biological role of active components in disease management in the plant have contributed to an active interest in the plant worldwide. Extracts of T. cordifolia are widely used as anti-spasmodic, anti-microbial, antiperiodic, immunomodulatory, anti-inflammatory, anti-arthritic, anti-allergic, endocrine disorders like anti-diabetic, hypolipidaemic, etc. in various herbal formulations to treat different diseases. It helps reduce the resistance to insulin and stress, revitalises all the tissues of the body, and spontaneously promotes metabolism. However, this adaptogenic ability is also under-explored. Stress and ageing disorders need to be treated independently. The current review paper mainly focused on stress, depression, and the anti-stress properties (adaptogen) of T. cordifolia. Depression and stress, along with disrupted metabolic and reproductive properties, are high-risk factors in polycystic ovarian syndrome patients. Further studies are needed to focus on adaptogenic activity to relieve certain endocrine disorders that occur due to stress, often ovarian cysts, female menstrual irregularities, and hormonal imbalance.

Keywords


Adaptogenic Property, Polycystic Ovarian Syndrome, Stress, Tinospora Cordifolia.

References





DOI: https://doi.org/10.18311/ti%2F2022%2Fv29i2%2F29358