Toxicology International (Formerly Indian Journal of Toxicology)

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Toxic Effects of Sub-chronic Oral Exposure of Imidacloprid on Biochemical Parameters in Buffalo Calves


Affiliations
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab,, India
     

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Imidacloprid, is a highly effective and widely used neonicotinoid insecticide for crop protection and veterinary pest control, which has gained a major market control in the past several years. The present investigation was undertaken to evaluate the toxic potential of imidacloprid in buffalo calves when administered for prolonged periods. Evaluation of various biochemical markers of hepatic, renal and muscular injury was done using standardized procedures. Oral administration of imidacloprid (@ 0.5 mg/kg/day; 90 days) in male buffalo calves, produced varying degrees of nasal discharge, lachrymal discharge, lethargy and weakness. Imidacloprid exposure caused a significant increase in the levels of plasma aspartate aminotransferase (12.3%), alanine aminotransferase (172.2%), lactate dehydrogenase (13.7%), gamma-glutamyltranspeptidase (57.5%), alkaline phosphatase (37.2%), acid phosphatase (220.0%), blood urea nitrogen (148.4%), creatinine (5.22%) and cholesterol (68.9%). However, no significant changes were observed in the enzymatic activity of creatine kinase, plasma cholinesterase as well as total protein and glucose levels.

Keywords

Biochemical, Buffalo Calves, Imidacloprid, Subchronic.
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  • Toxic Effects of Sub-chronic Oral Exposure of Imidacloprid on Biochemical Parameters in Buffalo Calves

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Authors

Tsewang Dorjay
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab,, India
Rajdeep Kaur
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab,, India
S. P. S. Saini
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab,, India
H . S. Sandhu
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab,, India

Abstract


Imidacloprid, is a highly effective and widely used neonicotinoid insecticide for crop protection and veterinary pest control, which has gained a major market control in the past several years. The present investigation was undertaken to evaluate the toxic potential of imidacloprid in buffalo calves when administered for prolonged periods. Evaluation of various biochemical markers of hepatic, renal and muscular injury was done using standardized procedures. Oral administration of imidacloprid (@ 0.5 mg/kg/day; 90 days) in male buffalo calves, produced varying degrees of nasal discharge, lachrymal discharge, lethargy and weakness. Imidacloprid exposure caused a significant increase in the levels of plasma aspartate aminotransferase (12.3%), alanine aminotransferase (172.2%), lactate dehydrogenase (13.7%), gamma-glutamyltranspeptidase (57.5%), alkaline phosphatase (37.2%), acid phosphatase (220.0%), blood urea nitrogen (148.4%), creatinine (5.22%) and cholesterol (68.9%). However, no significant changes were observed in the enzymatic activity of creatine kinase, plasma cholinesterase as well as total protein and glucose levels.

Keywords


Biochemical, Buffalo Calves, Imidacloprid, Subchronic.

References





DOI: https://doi.org/10.18311/ti%2F2020%2Fv27i3%264%2F22489