Toxicology International (Formerly Indian Journal of Toxicology)

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Effect of Fenugreek Against Induced Sub Acute Thiacloprid Toxicity in Rats


Affiliations
1 Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan,, India
     

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The study was carried out to investigate efficacy of fenugreek against general toxicity induced by sub acute exposure of thiacloprid in rats. Wistar rats were divided in four groups having six rats in each group. Group I served as control (corn oil administered as vehicle). Group II served as thiacloprid treated group (@ 22.5 mg/kg b.wt. orally), in Group III (experimental group) thiacloprid along with fenugreek extract (@500 mg/kg.b.wt.orally) and in case of Group IV (experimental group) fenugreek seeds extract (@500 mg/kg.b.wt.orally)were administered. The thiacloprid treated groups showed clinical signs viz lacrimation, piloerection, diarrhoea and dyspnea and significantly decreased absolute and relative body weight, higher relative liver and kidney weight, decreased relative spleen weight and altered hemo-biochemical profile. Fenugreek treatment showed improvement in absolute and relative body weight and organ weight and hemo-biochemical profile. The ethanolic extract of fenugreek has the potential to restore the general toxicity, serum biochemical and hematological parameters caused by sub-acute thiacloprid toxicity.

Keywords

Fenugreek, Rats, Sub-acute Toxicity, Thiacloprid.
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  • Effect of Fenugreek Against Induced Sub Acute Thiacloprid Toxicity in Rats

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Authors

Shweta Anand
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan,, India
Abhisek Choudhary
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan,, India
Sunil Boghia
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan,, India
Rahul Swarnkar
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan,, India
Devendra Singh
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navania, Vallabhnagar, Udaipur (RAJUVAS) – 313601, Rajasthan,, India

Abstract


The study was carried out to investigate efficacy of fenugreek against general toxicity induced by sub acute exposure of thiacloprid in rats. Wistar rats were divided in four groups having six rats in each group. Group I served as control (corn oil administered as vehicle). Group II served as thiacloprid treated group (@ 22.5 mg/kg b.wt. orally), in Group III (experimental group) thiacloprid along with fenugreek extract (@500 mg/kg.b.wt.orally) and in case of Group IV (experimental group) fenugreek seeds extract (@500 mg/kg.b.wt.orally)were administered. The thiacloprid treated groups showed clinical signs viz lacrimation, piloerection, diarrhoea and dyspnea and significantly decreased absolute and relative body weight, higher relative liver and kidney weight, decreased relative spleen weight and altered hemo-biochemical profile. Fenugreek treatment showed improvement in absolute and relative body weight and organ weight and hemo-biochemical profile. The ethanolic extract of fenugreek has the potential to restore the general toxicity, serum biochemical and hematological parameters caused by sub-acute thiacloprid toxicity.

Keywords


Fenugreek, Rats, Sub-acute Toxicity, Thiacloprid.

References





DOI: https://doi.org/10.18311/ti%2F2020%2Fv27i3%264%2F25382