Toxicology International (Formerly Indian Journal of Toxicology)

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Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats


Affiliations
1 Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, India
2 Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Korutla, Jagtial District – 505326, Telangana, India
3 Controller of Examinations, PVNRTVU, Administrative Office, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, India
4 Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Mamnoor, Warangal District – 506166 , Telangana, India
5 Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, India
     

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The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section in group 2 revealed mild degenerative changes  in group 3; in group 4 mild to moderate peri portal fibrosis.  Kidney section in group 2 showed  shrunken glomeruli, necrosis;  kidney section showed degeneration and necrosis of tubular epithelium with casts in the lumen in group 3 and  necrosis with casts in the lumen in group 4. Brain section in group 2 showed mild perivascular cuffing,  mild to moderate degeneration of Purkinji cells in group 3 and in group 4 degeneration of Purkinje cells. Effects in G-4 were severe than individual groups due to synergistic action of the combined pollutants than the individual effects.


Keywords

Cadmium, Chlorpyrifos, Lipid Peroxidation, Wistar Rats.
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  • Cadmium and Chlorpyrifos Induced Lipid Peroxidation in Brain, Liver and Kidney of Wistar Rats

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Authors

Y. Ravikumar
Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, India
D. Madhuri
Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Korutla, Jagtial District – 505326, Telangana, India
M. Lakshman
Department of Veterinary Pathology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, India
A. Gopalareddy
Controller of Examinations, PVNRTVU, Administrative Office, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, India
B. Kalakumar
Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Mamnoor, Warangal District – 506166 , Telangana, India
B. Anilkumar
Department of Pharmacology and Toxicology, College of Veterinary Science, PVNRTVU, Rajendranagar, Hyderabad – 500030, Telangana, India

Abstract


The work was designed with 4 groups for 28 days. 1: Control. 2: CdCl2 @ 22.5mg/ kg b.wt / oral. 3: CPF @ 25 mg/ kg b.wt /per oral. 4: CdCl2@22.5 mg + CPF @ 25 mg/ kg b.wt /per oral. Higher mean values of liver, kidney and brain TBARS were observed in G-2, 3 and 4 on 15th and 29th day. Liver section in group 2 revealed mild degenerative changes  in group 3; in group 4 mild to moderate peri portal fibrosis.  Kidney section in group 2 showed  shrunken glomeruli, necrosis;  kidney section showed degeneration and necrosis of tubular epithelium with casts in the lumen in group 3 and  necrosis with casts in the lumen in group 4. Brain section in group 2 showed mild perivascular cuffing,  mild to moderate degeneration of Purkinji cells in group 3 and in group 4 degeneration of Purkinje cells. Effects in G-4 were severe than individual groups due to synergistic action of the combined pollutants than the individual effects.


Keywords


Cadmium, Chlorpyrifos, Lipid Peroxidation, Wistar Rats.

References