Open Access
Subscription Access
Open Access
Subscription Access
Effect of Isolated Fraction from Biophytum reinwardtii on Dexamethasone Induced Insulin Resistance in Rats
Subscribe/Renew Journal
The Fraction from Methanolic extract whole plant of Biophytum reinwardtii (HEMBR) is traditionally used in the treatment of diabetes. Rats were treated with a standardized dose of Dexamethasone for 14 days and the effect of HEMBR at the doses of 50 and 100 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD and catalase), and body weight were observed. HEMBR showed a significant decrease in plasma glucose and serum triglyceride levels (p < 0.01) at the dose of 50 and 100 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes, GSH, SOD, and catalase were significantly increased (p < 0.01). Hence it can be concluded that Biophytum reinwardtii may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.
Keywords
Antioxidants, Diabetes, Fraction, Insulin, Resistance
User
Subscription
Login to verify subscription
Font Size
Information
- Sarwar N, Gao P, Seshasai SR, Gobin R, Kaptoge S, Di Angelantonio, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies. Emerging Risk Factors Collaboration. 2010; 375:2215- 22. https://doi.org/10.1016/S0140-6736(10)60484-9 PMid:20609967
- Bourne RR, Stevens GA, White RA, Smith JL, Flaxman SR, Price H, et al. Causes of vision loss worldwide, 1990-2010: A systematic analysis. Lancet Global Health 2013; 1:e339-49. https://doi.org/10.1016/S2214- 109X(13)70113-X PMid:25104599
- USRDS Annual Data Report. Epidemiology of kid¬ney disease in the United States. United States Renal Data System. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD; 2014. p. 188-210.
- Fowler MJ. Diabetes treatment, Part 2: Oral agents for glycemic management. Clin Diabetes. 2007; 25:131-4 https://doi.org/10.2337/diaclin.25.4.131
- Geer EB, Islam J, Buettner C. Mechanisms of glucocorti¬coid-induced insulin resistance: Focus on adipose tissue function and lipid metabolism. Endocrinol Metab Clin North Am. 2014; 43:75-102. https://doi.org/10.1016/j. ecl.2013.10.005 PMid:24582093 PMCid:PMC3942672
- Brady VJ, Grimes D, Armstrong T, LoBiondo-Wood G. Management of steroid-induced hyperglycemia in hos¬pitalized patients with cancer: A review. Oncol Nurs Forum. 2014; 41:E355-65. https://doi.org/10.1188/14. ONF.E355-E365 PMid:25355031
- Pagano G, Cavallo-Perin P, Cassader M, Bruno A, Ozzello A, Masciola P, et al. An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects. J Clin Invest. 1983; 72:1814-20. https://doi.org/10.1172/JCI111141 PMid:6355186 PMCid:PMC370470
- van Raalte DH, Ouwens DM, Diamant M. Novel insights into glucocorticoid-mediated diabetogenic effects: towards the expansion of therapeutic options? Eur J Clin Invest. 2009; 39:81-93. https://doi.org/10.1111/j.1365- 2362.2008.02067.x PMid:19200161
- Sakoda H, Ogihara T, Anai M, Funaki M, Inukai K, Katagiri H, et al. Dexamethasone-induced insulin resistance in 3T3L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduc¬tion. Diabetes. 2000; 49:1700-8. https://doi.org/10.2337/ diabetes.49.10.1700 PMid:11016454
- Nalini K, Karanth KS, Rao A, Aroor AR. Effects of Celastrus paniculatous on passive avoidance per-formance and biogenic amine turnover in albino rats. J Ethnopharmacol 1995; 47:1018. https://doi. org/10.1016/0378-8741(95)01264-E PMid:7500635
- Subha D, Geetha N. Evaluation of acute toxicity of the methanolic extract of Tanacetum parthenium L. in albino wistar rats. Journal of Scientific and Innovative Research. 2017; 6(3):113-5. https://doi.org/10.31254/ jsir.2017.6307
- Gholap S, Kar A. Gymnemic acids from Gymnema syl¬vestre potentially regulate dexamethasone-induced hyperglycemia in mice. Pharmaceutical Biology. 2005; 43:192-5. https://doi.org/10.1080/13880200590919564
- Ellaman GL. Tissue sulfhydryl group. Archives Biochemistry and Biophysiology. 1959; 6:70-7. https:// doi.org/10.1016/0003-9861(59)90090-6 PMid:13650640
- Mishra HP, Fridovich I. Role of superoxide anion in auto-oxidation of epinephrine and a simple assay for superoxide dismutase. Journal of Biological Chemistry. 1972; 247:3170-5. https://doi.org/10.1016/S0021- 9258(19)45228-9
- Bergmeyer H-U. Methods of Enzymatic Analysis. Chemic Academic Press Inc; 1974. p. 673-85.
- Sabu MC, Subburaju T. Effect of Cassia auriculata Linn. onserum glucose level, glucose utilization by isolated rat hemidia-phragm. Journal of Ethnopharmacology. 2002; 80:203-6. https://doi.org/10.1016/S0378- 8741(02)00026-0 PMid:12007712
- Harber RS, Weinstein SP. Role of glucose transporter in glucocorticoid induced insulin resistance GLUT4 isoform in rat skeletal muscle is not decreased by Dexamethasone. Diabetes. 1992; 41:728-35. https://doi. org/10.2337/diab.41.6.728
- Kim DS, Kim TW, Park IK, Kang JS, Om AS. Effect of chromium picolinate supplementation on insulin sensitivity, serum lipid, and body weight in dexametha¬sone-treated rats. Metabolism. 2002; 51:589-94. https:// doi.org/10.1053/meta.2002.31985 PMid:11979390
- Schmidt TJ, Miller-Diener A, Litwack G. Lapachone, a specific competitive inhibitor of ligand binding to the glucocorti-coid receptor. The Journal of Biological Chemistry. 1984; 259:9536-43. https://doi.org/10.1016/ S0021-9258(17)42733-5 PMid:6746659
- Marfella R, Quagliaro L, Nappo F, Ceriello A, Giugliano D. Acute hyperglycemia induces an oxidative stress in healthy subjects. Journal of Clinical Investigation. 2001; 108:635-6. https://doi.org/10.1172/JCI13727 PMid:11518739 PMCid:PMC209408
Abstract Views: 149
PDF Views: 0