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Rai, Rajalakshmi
- Therapeutic Potential of Pomegranate Juice In Wistar Rats Against Aluminium Induced Neurotoxicity
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1 Department of Anatomy, Sri Venkateshwara Medical College Hospital and Research Centre, Ariyur, Puducherry – 605102, IN
2 Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore – 575001, Karnataka, IN
3 Department of Anatomy, College of Medicine, American University of Antigua, Coolidge, AG
1 Department of Anatomy, Sri Venkateshwara Medical College Hospital and Research Centre, Ariyur, Puducherry – 605102, IN
2 Department of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore – 575001, Karnataka, IN
3 Department of Anatomy, College of Medicine, American University of Antigua, Coolidge, AG
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Toxicology International (Formerly Indian Journal of Toxicology), Vol 28, No 4 (2021), Pagination: 357-364Abstract
Neurodegenerative disorders are the major challenges faced by the global health care system in recent years. It is a well-known fact that a number of environmental as well as lifestyle factors are responsible for neurodegenerative diseases and the contribution by aluminium (Al) plays a major role in this. A diet containing considerably high traces of Al may cause neurotoxicity leading to memory loss, impaired coordination as well as a cognitive disturbance. The present study is designed to evaluate the neuroprotective role of Pomegranate Juice (PJ) since it is rich in polyphenols that have antioxidant properties. We evaluated neurodegenerative changes induced by AlCl3 in the hippocampus of Wistar rats as well as cognitive changes displayed by them. Then compared it with that of PJ treated rats which were previously administered with AlCl3 . A significantly decreased (p<0.001) number of viable neurons were seen, in different regions of the hippocampus in the AlCl3 administered rats in comparison to the animals of the control group. However, the number of viable neurons significantly boosted (p<0.001) in PJ treated rat hippocampus. This suggests that neurotoxic changes induced by the aluminum can be ameliorated by treatment with PJ.Keywords
Aluminium Neurotoxicity, Hippocampus, Neurodegeneration, Pomegranate
References
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- Influence of Vitamin D on Ethanol Induced Retinal Changes in Experimental Rats
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Authors
Affiliations
1 Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka,, IN
2 Department of Anatomy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka,, IN
3 Department of Anatomy, American University of Antigua College of Medicine, Coolidge, P.O. Box 1451, Antigua, US
4 Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka,, IN
1 Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka,, IN
2 Department of Anatomy, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka,, IN
3 Department of Anatomy, American University of Antigua College of Medicine, Coolidge, P.O. Box 1451, Antigua, US
4 Department of Biochemistry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka,, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 29, No 1 (2022), Pagination: 65-74Abstract
Retina is a neurosensory tissue of ocular system having highly unique lipids which are susceptible to free radical injuries. Chronic ethanol consumption can initiate a wide range of disorders in the CNS and also alteration in the visual system via oxidative pathway. Our study was designed to evaluate the role of vitamin D, a well-known antioxidant and neuroprotective steroid hormone, in the maintenance of ocular health in ethanol induced toxicity. In our present study 4 months old Wistar rats were exposed to ethanol, daily for 6 weeks, while another set of rats received ethanol daily, along with vitamin D for the same duration. A control group consisting of normal rats without any treatment was also included in this experiment. After 6 weeks, Total Anti-Oxidant (TAO) level of eyeball and retinal thickness was measured and statistically analyzed. We observed significantly decreased total antioxidant level in whole eye homogenate in ethanol administered rats which was associated with morphometric changes in the retina. Whereas, vitamin D treated rats showed near to normal retinal morphology as well as TAO level suggesting that vitamin D has the potential to reverse retinal damages caused by ethanol toxicity induced by long term consumption of it.Keywords
Ethanol, Retina, Toxicity, Vitamin D.References
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