Asian Journal of Pharmaceutical Research and Health Care

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Two simple and sensitive visible spectrophotometric methods are described for the determination of tianeptine in bulk and pharmaceutical preparations based on the formation of colored species with SA- NaNO 2 - α - NA (M 1 ) or SNP-acetaldehyde reagent (M 2 ) under specified experimental conditions and exhibiting λ max at 479 nm or 555nm respectively. The Regression analysis of Beer's Law plot showed good correlation in a general concentration range of 10-30μg/ml or 8.0-24μg/ml with correlation coefficient (r 2 = 0.999) for methods M 1 and M 2 respectively. The proposed methods are applied to commercial available stablon tablets and the results are statistically compared with those obtained by the UV reference method and validated with respect to accuracy, precision, linearity, limit of detection, percentage of recovery, repeatability and recovery studies. The results are found satisfactory and reproducible. These methods are applied successfully for the estimation of tianeptine in tablet form without the interference of excipients.

Keywords

Assay, Acetaldehyde, Coupling, Diazotization, Regression Equation, Sodium Nitroprussi.
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