Preparation and Evaluation of Extended Release Nimesulide Tablet Based on Diffusion Controlled Mechanism

Now a days the concept of controlled release is quiet popular amongst the formulation scientists. The aim of this study was to develop a once-daily sustained release matrix tablet of Nimesulide using hydroxyl propyl methylcellulose (HPMC K4M) as release controlling factor and to evaluate drug release parameters as per various release kinetic models. The tablets were prepared using wet granulation method. Total of five batches were prepared from which two selected batches were further evaluated. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. The ''n'' Value of both batches indicates that the drug release mechanism follows ''Anomalous Transport''. From all these data it is quite clear that batch F2 is optimized as its release kinetic was found to be as per Korsmeyer Peppas model rather than first order of F4.