Molecular Analysis of Streptococcus thermophilus Supporting Probiotic Action towards Drug Targets

Streptococcus thermophilus is a Gram-positive facultative anaerobe with probiotic action. Nearly 2070 genes are predicted in complete genome out of which 566 genes are related to hypothetical and uncharacterized genes. The predicted gene percent obtained by characterization of complete genome of S.thermophilus is 72.67% with 25 functional categories. There is high number of transport, protein synthesis, binding and cell envelop proteins that don't have pathogen responses. The genes ptsK, glgP, malQ, lacZ, amyL, scrB, etc are related to energy metabolism (with biodegradation and synthesis of polysaccharides) are found in chromosome CNRZ 1066. The genes such as glgP, malQ, lacZ and amyl had shown direct interactions that has not found direct link with scrB gene. All the proteins are observed with more the 50 percent identities that are present in homology models.