Asian Journal of Pharmaceutical Research and Health Care

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Screening of HMG Co a Reductase Inhibitor Producing Marine Actinomycetes


Affiliations
  • Andhra University, Pharmaceutical Biotechnology Division, A.U. College of Pharmaceutical Sciences, India
  • Andhra University, Department of Botany, College of Science and Technology, Visakhapatnam, India
 

The objective of the present study was screening of 3-hydroxy-3- methyl glutaryl Co A (HMG Co A) reductase inhibitor producing marine actinomycetes. A total of 65 morphologically different actinomycetes were screened for HMG Co A reductase inhibitor production in a two stage submerged fermentation and evaluated for HMG CoA reductase inhibitor activity by agar diffusion and thin layer chromatography technique using lovostatin as a control. Among 65 marine Actinomycete strains, only one strain produced HMG Co A reductase inhibitor.

Keywords

Lovastatin, Marine Actinomycetes, HMG Co A Reductase Inhibitor.
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  • Screening of HMG Co a Reductase Inhibitor Producing Marine Actinomycetes

Abstract Views: 369  |  PDF Views: 172

Authors

M. Srinu
, India
Feleke Moges
, India
J. Srilakshmi
, India
G. Sankar
, India
T. Prabhakar
, India

Abstract


The objective of the present study was screening of 3-hydroxy-3- methyl glutaryl Co A (HMG Co A) reductase inhibitor producing marine actinomycetes. A total of 65 morphologically different actinomycetes were screened for HMG Co A reductase inhibitor production in a two stage submerged fermentation and evaluated for HMG CoA reductase inhibitor activity by agar diffusion and thin layer chromatography technique using lovostatin as a control. Among 65 marine Actinomycete strains, only one strain produced HMG Co A reductase inhibitor.

Keywords


Lovastatin, Marine Actinomycetes, HMG Co A Reductase Inhibitor.