Asian Journal of Pharmaceutical Research and Health Care

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In this study, a new and rapid spectrofluorometry method was developed for determination of atenolol in pure and pharmaceutical preparation. The solvent system and wavelength of detection were optimized in order to maximize the sensitivity of the proposed method. Parameters such as linearity, precision, accuracy, specificity, stability, limit of detection and limit of quantification were studied according to the International Conference on Harmonization (ICH) Guidelines. The linearity was established between the concentration range of 50-4000 ng/mL. The intra- and inter-day relative standard deviation (RSD) was less than 2.97%. Limits of detection and quantification were determined as 15.2 and 46.1 ng/mL, respectively. The mean recovery value of atenolol was 99.3% for pharmaceutical preparation. The method was applied for the quality control of commercial atenolol dosage form to quantify the drug and to check the formulation content uniformity.

Keywords

Atenolol, Spectrofluorometry, Validation, Tablet.
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