Asian Journal of Pharmaceutical Research and Health Care

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Studies on the Preparation, Characterization and Solubility of β-Cyclodextrin-Nelfinavir Inclusion Complexes


Affiliations
  • PRES'S College of Pharmacy, Nashik, India
  • P. D. V. V. P. F'S College of Pharmacy, Ahmednagar, India
  • Oriental College of Pharmacy, Bhopal, India
  • Padm. Dr. D. Y. Patil College of Pharmacy, Pune, India
 

Nelfinavir is a poor water-soluble antiretroviral drug with relatively low bioavailability. The effect of β-cyclodextrin on the aqueous solubility and dissolution rate of nelfinavir was investigated. Phase solubility studies indicated that the solubility of nelfinavir was significantly enhanced by complexing it with β- cyclodextrin. It was classified as Bs type indicating the 1:2 stoichiometric inclusion complexes. The various solid complexes prepared by physical mixture, Kneading, coprecipitation & common solvent methods were characterized by DSC, X-RD & FT-IR. Dissolution study showed that the solubility and dissolution rate of nelfinavir was significantly improved by complexation with β-cyclodextrin.

Keywords

β-Cyclodextrin, Physical Mixture, Kneading Method, Coprecipitation and Common Colvent Method.
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  • Studies on the Preparation, Characterization and Solubility of β-Cyclodextrin-Nelfinavir Inclusion Complexes

Abstract Views: 236  |  PDF Views: 130

Authors

S. N. Hiremath
, India
G. R. Godge
, India
A. A. Kharia
, India
V. R. Vaidya
, India

Abstract


Nelfinavir is a poor water-soluble antiretroviral drug with relatively low bioavailability. The effect of β-cyclodextrin on the aqueous solubility and dissolution rate of nelfinavir was investigated. Phase solubility studies indicated that the solubility of nelfinavir was significantly enhanced by complexing it with β- cyclodextrin. It was classified as Bs type indicating the 1:2 stoichiometric inclusion complexes. The various solid complexes prepared by physical mixture, Kneading, coprecipitation & common solvent methods were characterized by DSC, X-RD & FT-IR. Dissolution study showed that the solubility and dissolution rate of nelfinavir was significantly improved by complexation with β-cyclodextrin.

Keywords


β-Cyclodextrin, Physical Mixture, Kneading Method, Coprecipitation and Common Colvent Method.