Formulation and Process Optimization of Gastro-Retentive Floating Tablet of Ondansetron HCL

Ondansetron HCl is a potent, highly selective 5 - HT3 receptor - antagonist used to prevent nausea and vomiting, mainly in patients undergoing chemotherapy and radiation treatments. The aim of present work was to f ormulate, evaluat e and optimize gastro - retentive tablet of Ondansetron HCl which would be advantageous, that can provide prolong gastric retention and increase efficacy of the dosage form. In formulation optimization, different formulation of HPMC polymer , NaCMC and NaHCO₃ were studied with help of 3 ² full factorial designs. It was found that HPMC K4M with concentratio n 40% , NaCMC 5% and NaHCO ₃ with 17% concentrations showed good sustained and floating ability and it releases 94.51% drug within 24 hrs. During study of effec t of process parameters, it was concluded that release of drug decreases with decreasing granular size. The drying time (10 and 20 min) and drying temperature (40° and 50°C), does not have any significant effect on the release profile of drug.